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RISS 인기검색어
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- 저자 : Keiichi Yokoyama (검색결과 3 건)
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Influence of Repeated Senna Laxative Use on Skin Barrier Function in Mice
( Satoshi Yokoyama ),( Keiichi Hiramoto ),( Yurika Yamate ),( Kazuya Ooi ) 대한피부과학회 2017 Annals of Dermatology Vol.29 No.4
Background: Senna, one of the major stimulant laxatives, is widely used for treating constipation. Chronic senna use has been reported to be associated with colonic disorders such as melanosis coli and/or epithelial hyperplasia. However, there is no obvious information on the influence of chronic senna use on organs except for the intestine. Objective: To clarify the influence of senna laxative use on skin barrier function by repeated senna administration. Methods: Eight-week-old male hairless mice received senna (10 mg/kg/day) for 21 days. After administration, we evaluated transepidermal water loss (TEWL), and investigated the bio-markers in plasma and skin using protein analysis methods. Results: Fecal water content on day seven was significantly increased; however, on day 21, it was significantly de-creased after repeated senna administration. In the senna-ad-ministered group, TEWL was significantly higher compared to the control on days seven and 21. Plasma acetylcholine concentration and NO<sub>2</sub> <sup>-</sup>/NO<sub>3</sub> <sup>-</sup> were increased on days sev-en and 21, respectively. In skin, tryptase-positive mast cells and inducible nitric oxide synthase (iNOS)-positive cells were increased on days seven and 21, respectively. The in-crease of TEWL on days seven and 21 was suppressed by the administration of atropine and N(G)-nitro-L-arginine methyl ester, respectively. Conclusion: It was suggested that diar-rhea or constipation induced by repeated senna admin-istration caused the impairment of skin barrier function. There is a possibility that this impaired skin barrier function occurred due to degranulation of mast cells via cholinergic signals or oxidative stress derived from iNOS. (Ann Dermatol 29(4) 414∼421, 2017)
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Leo Matsuoka,Tatsuya Kasajima,Masashi Hashimoto,Keiichi Yokoyama 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.41
We propose an implementation scheme for the continuous-time quantum walk using a diatomic molecule and an optical frequency comb. We show an analogy between the quantum walk and the cascade rotational transitions induced by the optical frequency comb whose frequency peaks are tuned to the pure rotational transitions in the molecule. A strategy to compensate for the centrifugal distortion of the real molecule is also demonstrated.
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The Association of Fever with Total Mechanical Ventilation Time in Critically Ill Patients
박동원,Moritoki Egi,Masaji Nishimura,장유진,서기영,임채만,김재열,Keiichi Tada,Koichi Matsuo,Shinhiro Takeda,Ryosuke Tsuruta,Takeshi Yokoyama,김선옥,고윤석 대한의학회 2016 Journal of Korean medical science Vol.31 No.12
This research aims to investigate the impact of fever on total mechanical ventilation time (TVT) in critically ill patients. Subgroup analysis was conducted using a previous prospective, multicenter observational study. We included mechanically ventilated patients for more than 24 hours from 10 Korean and 15 Japanese intensive care units (ICU), and recorded maximal body temperature under the support of mechanical ventilation (MAXMV). To assess the independent association of MAXMV with TVT, we used propensity-matched analysis in a total of 769 survived patients with medical or surgical admission, separately. Together with multiple linear regression analysis to evaluate the association between the severity of fever and TVT, the effect of MAXMV on ventilator-free days was also observed by quantile regression analysis in all subjects including non-survivors. After propensity score matching, a MAXMV ≥ 37.5°C was significantly associated with longer mean TVT by 5.4 days in medical admission, and by 1.2 days in surgical admission, compared to those with MAXMV of 36.5°C to 37.4°C. In multivariate linear regression analysis, patients with three categories of fever (MAXMV of 37.5°C to 38.4°C, 38.5°C to 39.4°C, and ≥ 39.5°C) sustained a significantly longer duration of TVT than those with normal range of MAXMV in both categories of ICU admission. A significant association between MAXMV and mechanical ventilator-free days was also observed in all enrolled subjects. Fever may be a detrimental factor to prolong TVT in mechanically ventilated patients. These findings suggest that fever in mechanically ventilated patients might be associated with worse mechanical ventilation outcome.
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