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RISS 인기검색어
- 검색키워드
- 저자 : Kanako Matsuoka (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Optimizing Contrast Medium Injection for Coronary CT Angiography Using Myocardial CT Perfusion Data
Tomizawa Nobuo,Chou Shengpu,Matsuoka Satoshi,Yamamoto Kodai,Inoh Shinichi,Nojo Takeshi,Kumamaru Kanako Kunishima,Fujimoto Shinichiro,Nakamura Sunao 아시아심장혈관영상의학회 2019 Cardiovascular Imaging Asia Vol.3 No.4
Objective: To derive and validate a formula to predict the optimal amount of contrast medium for coronary CT angiography (CTA) from CT perfusion (CTP) data during comprehensive cardiac CT. Materials and Methods: The derivation and validation group consisted of 196 and 41 patients, respectively. Dynamic CTP was performed under adenosine triphosphate stress of 0.14 mg/kg/min, followed by rest coronary CTA. Time to peak (TTP) and peak enhancement (PE) in the left ventricle during CTP was recorded. The amount of contrast medium during CTA was 0.8×body weight (kg) in the derivation group. A formula to determine the amount of contrast medium needed to achieve an enhancement of 370 Hounsfield unit (HU) in CTA was derived using TTP, PE, body weight, and heart rate. The amount of contrast medium required during CTA in the validation group was determined by this formula. Results: The mean amount of contrast medium during CTA did not differ between the derivation and validation groups (49.3±8.0 mL vs. 47.9±12.9 mL, p=0.39). The mean coronary artery enhancement was slightly lower in the validation group (400±55 HU vs. 380±46 HU, p=0.03) with smaller interpatient variability (p=0.02) than in the derivation group. The proportion of patients with an optimal enhancement of 320 HU to 420 HU significantly increased from 54% to 75% (p=0.01) when the formula was used. Conclusion: Adjusting the amount of contrast medium using dynamic CTP data could reduce the interpatient variability of coronary enhancement during comprehensive cardiac CT.
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Low Iodine Dose is Related with Overestimation of Extracellular Volume Derived from Cardiac CT
Hiroaki Arakawa,Nobuo Tomizawa,Shengpu Chou,Satoshi Matsuoka,Kodai Yamamoto,Shinichi Inoh,Takeshi Nojo,Kanako Kunishima Kumamaru,Shinichiro Fujimoto,Sunao Nakamura 아시아심장혈관영상의학회 2020 Cardiovascular Imaging Asia Vol.4 No.2
Objective: To assess the relationship between the amount of injected contrast medium and the extracellular volume (ECV) value during cardiac CT and to propose a minimum amount of contrast medium necessary to correctly calculate ECV. Materials and Methods: A total of 95 patients who underwent comprehensive cardiac CT were included. Patients first underwent myocardial CT perfusion (CTP) with a contrast medium dose determined by the body weight (<70 kg: 50 mL; 70–89 kg: 55 mL; ≥90 kg: 60 mL). Coronary CT angiography (CTA) scan followed with a contrast medium dose of 0.8×body weight (kg). We defined the ECV value calculated after CTP as ECVCTP, and we used the ECV value calculated after the CTA exam as the reference standard (ECVref). We calculated the difference in ECV values (ECVdiff) as ECVCTP-ECVref. Results: The injected iodine doses during CTP and the entire exam were 284±50 and 559± 69 mg iodine/kg, respectively. There was a weak but significant negative relationship (R2 =0.07, p=0.01) between the injected iodine dose during CTP and ECVdiff. The ECVdiff of patients who received an injected iodine dose of <285 mg iodine/kg during CTP was significantly higher (2.7±4.1 vs. 0.8±3.4%, p=0.02) than that of the remaining patients. Conclusion: ECV derived from cardiac CT might be overestimated when a small amount of contrast medium is injected. Inj
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Joonbeom Kwon,김덕윤,조강준,Mamoru Hashimoto,Kanako Matsuoka,Tadanobu Kamijo,Zhou Wang,Sergei Karnup,Anne M. Robertson,Pradeep Tyagi,Naoki Yoshimura 대한배뇨장애요실금학회 2024 International Neurourology Journal Vol.28 No.-
Overactive bladder (OAB) is a symptom-based syndrome defined by urinary urgency, frequency, and nocturia with or without urge incontinence. The causative pathology is diverse; including bladder outlet obstruction (BOO), bladder ischemia, aging, metabolic syndrome, psychological stress, affective disorder, urinary microbiome, localized and systemic inflammatory responses, etc. Several hypotheses have been suggested as mechanisms of OAB generation; among them, neurogenic, myogenic, and urothelial mechanisms are well-known hypotheses. Also, a series of local signals called autonomous myogenic contraction, micromotion, or afferent noises, which can occur during bladder filling, may be induced by the leak of acetylcholine (ACh) or urothelial release of adenosine triphosphate (ATP). They can be transmitted to the central nervous system through afferent fibers to trigger coordinated urgency-related detrusor contractions. Antimuscarinics, commonly known to induce smooth muscle relaxation by competitive blockage of muscarinic receptors in the parasympathetic postganglionic nerve, have a minimal effect on detrusor contraction within therapeutic doses. In fact, they have a predominant role in preventing signals in the afferent nerve transmission process. β3-adrenergic receptor (AR) agonists inhibit afferent signals by predominant inhibition of mechanosensitive Aδ-fibers in the normal bladder. However, in pathologic conditions such as spinal cord injury, it seems to inhibit capsaicin-sensitive C-fibers. Particularly, mirabegron, a β3-agonist, prevents ACh release in the BOO-induced detrusor overactivity model by parasympathetic prejunctional mechanisms. A recent study also revealed that vibegron may have 2 mechanisms of action: inhibition of ACh from cholinergic efferent nerves in the detrusor and afferent inhibition via urothelial β3-AR.
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