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Junghyun Kim(Junghyun Kim),Dae-Eun Kim(Dae-Eun Kim),Eunseok Park(Eunseok Park),Dae-Jin Kim(Dae-Jin Kim),Hwanhee Kim(Hwanhee Kim) 한국보건의료윤리학회 2023 한국보건의료윤리학회지 Vol.2 No.1
Background: The purpose of this study is to provide basic data on the necessity and direction of education to establish a desirable bioethics view by identifying bioethics awareness of the Life-sustaining Treatment Decision Act among biomedical laboratory science student and nursing students attending K University. Methods: From October 30 to November 5, 2022, the final 279 people (144 in biomedical laboratory science and 135 in nursing) were analyzed through a structured survey of 29 questions. Results: As a result of comparing the presence or absence of learning and the degree of awareness of the life-sustaining treatment decision act, the presence or absence of learning p<.001. There was a statistically significant difference in cognitive degree p<.001. Conclusion: It is suggested that continuous research should be conducted to confirm the perception of biomedical ethics of Biomedical laboratory science students and nursing students and to find the need and direction of education to establish a desirable bioethics.
Kim, Junghyun,Lee, Yun Mi,Jung, Wookwon,Park, Su-Bin,Kim, Chan-Sik,Kim, Jin Sook Oxford University Press 2018 Evidence-based Complementary and Alternative Medic Vol.2018 No.-
<P> Aster koraiensis extract (AKE) is a standard dietary herbal supplement. Chlorogenic acid (CA) is the major compound present in AKE. Retinal neovascularization is a common pathophysiology of retinopathy of prematurity, diabetic retinopathy, and wet form age-related macular degeneration. In this study, we aimed to evaluate the effects of AKE and CA on retinal neovascularization in a mouse model of oxygen-induced retinopathy (OIR). Vascular endothelial growth factor- (VEGF-) induced tube formation was assayed in human vascular endothelial cells. Experimental retinal neovascularization was induced by exposing C57BL/6 mice to 75% oxygen on postnatal day 7 (P7) and then returning them to normal oxygen pressure on P12. AKE (25 and 50mg/kg/day) and CA (25 and 50mg/kg/day) were administered intraperitoneally for 5 days (P12-P16). Retinal flat mounts were prepared tomeasure the extent of retinal neovascularization at P17. The incubation of human vascular endothelial cells with AKE and CA (1-10 μg/mL) resulted in the inhibition of VEGF-mediated tube formation in a dose-dependent manner.The neovascular area was significantly smaller in AKE or CA-treated mice than in the vehicle-treated mice. These results suggest that AKE is a potent antiangiogenic agent and that its antiangiogenic activity may, in part, be attributable to the bioactive component CA. </P>
Subsequent platinum based re-treatment of platinum-resistant ovarian cancer: 7 cases review
( Junghyun Kim ),( Jina Yun ),( Ah Reum Chun ),( Se Hun Kim ),( Se Hyung Kim ),( Seong Kyu Park ),( Dae Sik Hong ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
Patients who relapse within 6 months after completion of therapy are thought to be “platinum-resistant"(Pt-R) and felt to have a worse prognosis. Currently, Single agent such as topotecan, liposomal doxorubicin, vinorelbine, docetaxel and gemcitabine is used as second line setting for patients with Pt-R ovarian cancer. But, some articles have been reported that patients who have Pt-R ovarian cancer may still benefit from re-treatment with platinum compounds after an interval of treatment with nonplatinum agents. The purpose of our study was to review our experience with subsequent platinum based re-treatment in women with Pt-R ovarian cancer. We studied seven patients who had relapsed within six months of their recent exposure to platinum. They were treated with platinum based combination with topotecan, irinotecan, or docetaxel. The median age was 52 years, six patients was received paclitaxel and carboplatin combination chemotherapy prior to re treatment with platinum compounds. They received a median number of six cycles as first line chemotherapy. Two patients achieved complete respons (CR) and 5 had stable disease(SD). The median time to progression(TTP) of 1st line treatment was 8.5 months (95% CI 7.8-9.3) and the median platinum free interval was 4.6 months. All of them had good performance status(ECOG 0) before 2nd line treatment. Four patients received docetaxel-carboplatin and 3 had topotecan/irinotecan-cisplatin combination regimen. A median number of 6 cycles as re treatment with platinum compounds was received. One patient achieved CR, one patient achieved partial response, while 5 patients achieved SD. The median TTP for these seven patients after re-treatment with platinum compounds was 7.3 months (95% CI 5.1-9.4). Four patients had progressive disease and received further salvage therapy with another regimen. The median overall survival from the time deemed to be Pt-R is 22.8 months (95% CI 18.8-26.8). Our small retrospective series suggest that the Pt-R category is still less clear. Patients who have been deemed Pt-R may still benefit from subsequent platinum based re-treatment.
Kim, Junghyun,Kim, Chan-Sik,Sohn, Eunjin,Kim, Jin Sook S. Karger AG 2011 Ophthalmic research Vol.46 No.2
<P>Advanced glycation end products including <I>N</I>ε-(carboxymethyl)lysine (CML) are believed to contribute to retinal pericyte loss in diabetic retinopathy. Nuclear factor-κB (NF-κB) activation has been considered as a potential cytotoxic modulator of retinal pericytes. Herein, we investigated whether CML accumulation can trigger NF-κB activation and apoptosis of retinal pericytes in streptozotocin (STZ)-induced diabetic rats. Seven-week-old Sprague-Dawley rats were made diabetic (STZ, 60 mg/kg). After 5 months, CML level and NF-κB activation were measured in trypsin-digested retinal vessels. In diabetic rats, TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling)-positive and caspase 3-positive retinal pericytes were significantly increased. CML and NF-κB activation was also markedly increased in diabetic retinal vessels. Moreover, the immunoreactivity of NF-κB was localized within the region where CML were accumulated. Apoptosis occurred in CML-accumulating retinal pericytes. These results suggest that NF-κB could be activated in CML-accumulating pericytes from diabetic retina. CML accumulation is responsible, at least in part, for the apoptosis of retinal pericytes.</P><P>Copyright © 2011 S. Karger AG, Basel</P>
Kim, Junghyun,Kim, Chan-Sik,Sohn, Eunjin,Lee, Yun Mi,Jo, Kyuhyung,Kim, Jin Sook Hindawi Publishing Corporation 2015 Evidence-based Complementary and Alternative Medic Vol.2015 No.-
<P>Aldose reductase (AR) is the first and rate-limiting enzyme of the polyol pathway. AR-dependent synthesis of excess polyols leads to lens opacification in diabetic cataract. The purpose of this study is to investigate the protective effect of <I>Litsea japonica</I> extract (LJE) on diabetes-induced lens opacification and its protective mechanism in db/db mice. Seven-week-old male db/db mice were treated with LJE (100 and 250 mg/kg body weight) once a day orally for 12 weeks. LJE dose dependently inhibited rat lens aldose reductase activity <I>in vitro</I> (IC<SUB>50</SUB> = 13.53 ± 0.74 <I>µ</I>g/mL). In db/db mice, lens was slightly opacified, and lens fiber cells were swollen and ruptured. In addition, lenticular sorbitol accumulation was increased in db/db mice. However, the administration of LJE inhibited these lenticular sorbitol accumulation and lens architectural changes in db/db mice. Our results suggest that LJE might be beneficial for the treatment of diabetes-induced lens opacification. The ability of LJE to suppress lenticular sorbitol accumulation may be mediated by the inhibition of AR activity.</P>
( Junghyun Kim ),( Woo Jin Kim ),( Bom Kim ),( So Hyeon Bak ),( Yeon-mok Oh ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Purpose The clinical and radiological presentation of chronic obstructive pulmonary disease (COPD) has proposed heterogeneity according to the sources of inflammation characterized in COPD. This study tried to evaluate COPD phenotypes for specific dust exposure. Method This study was designed to compare characteristics and clinical outcomes with radiological findings between the two prospective COPD cohorts representing a distinguishing region in the Korea; COPD in Dusty Area (CODA) and the Korean Obstructive Lung Disease (KOLD) cohort. A total of 733 participants (n=186 for CODA, and n=547 for KOLD, for each) were included in the final analysis. Multivariate analysis for the comparison of lung function and CT measurements of both study groups after adjusting for age, gender, education, body mass index, smoking status, pack-year, charlson comorbity index, and the frequency of exacerbation were done entering the level of FEV1(%), biomass exposure and COPD medication into the model in stepwise. Result There was no differences in mean wall area (70.2±1.26 in CODA vs. 67.07±0.90 in KOLD, p=0.121). KOLD, where the COPD subjects from urban and metropolitan area, showed higher emphysema index (6.07±3.06 in CODA vs. 20.0±2.21 in KOLD, p<0.001, respectively). This significance in emphysema index was consistent even after further adjustment for FEV1 (6.12±2.88 in CODA vs. 17.3±2.10 in KOLD, p=0.002, respectively). Mean wall area was also found to be significantly lower in KOLD (70.2±1.21 in CODA vs. 66.8±0.88 in KOLD, p=0.028) after including FEV1 into the model. However, there was no difference in lung density between the two groups (p=0.077). Additional adjustment for biomass parameter and medication for COPD did not alter the statistical significance after entering into the analysis with COPD medication. Conclusion Higher mean wall area and lower emphysema index were observed in dust exposure region. These Results suggest that imaging phenotype of COPD is influenced by the environmental exposure.
Effect of KIOM-79 on Diabetes-Induced Myocardial Fibrosis in Zucker Diabetic Fatty Rats
Kim, Junghyun,Sohn, Eunjin,Kim, Chan-Sik,Lee, Yun Mi,Jo, Kyuhyung,Kim, Jin Sook Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-
<P>KIOM-79, a herbal mixture of parched Puerariae radix, gingered Magnoliae cortex, Glycyrrhizae radix, and Euphorbiae radix, has a strong inhibitory effect on advanced glycation end products (AGEs) formation. We investigated the beneficial effects of KIOM-79 on cardiac fibrosis in Zucker diabetic fatty (ZDF) rats. KIOM-79 (50 or 500 mg/kg/day) was orally administered for 13 weeks. AGEs formation and collagen expression in the myocardium were assessed by immunohistochemistry. The expression levels of the receptor for AGEs (RAGE), transforming growth factor-<I><I>β</I></I>1 (TGF-<I><I>β</I></I>1), collagen IV, fibronectin, urotensin II, and urotensin II receptor were examined in the myocardial tissue of ZDF rats. KIOM-79 treatment at 500 mg/kg inhibited the accumulation of AGEs, reduced RAGE mRNA and protein expression, and reduced the upregulation of cardiac fibrogenic factors, such as fibronectin and collagen IV, in heart of ZDF rats. Additionally, KIOM-79 ameliorated urotensin II/receptor gene expression in the cardiac tissue of ZDF rats. Our findings indicate that KIOM-79 diminishes cardiac fibrosis in ZDF rats by preventing AGEs accumulation and RAGE overexpression and by modulating the cardiac urotensin II/receptor pathway, which decreases the amount of profibrotic factors, such as TGF-<I><I>β</I></I>1, fibronectin, and collagen in cardiac tissue.</P>
Kim, Young Sook,Lee, Youngseop,Kim, Junghyun,Sohn, Eunjin,Kim, Chan Sik,Lee, Yun Mi,Jo, Kyuhyung,Shin, Sodam,Song, Yoojin,Kim, Joo Hwan,Kim, Jin Sook Hindawi Publishing Corporation 2012 Evidence-based Complementary and Alternative Medic Vol.2012 No.-
<P>To identify effective herb to treat obesity, we screened 115 herbal extracts for inhibition of porcine pancreatic lipase (triacylg-ycerol acylhydrolase, EC 3.1.1.3) activity <I>in vitro</I>. Of the extracts tested, <I>Cudrania tricuspidata</I> leaves exhibited the most pronounced inhibitory effect on lipase activity with an IC<SUB>50</SUB> value of 9.91 <I><I>μ</I></I>g/mL. Antilipid absorption effects of <I>C. tricuspidata</I> leaves were examined in rats after oral administration of lipid emulsions containing 50 or 250 mg <I>C. tricuspidata</I>/kg body weight. Plasma triacylglycerol levels 2 h after the oral administration of emulsions containing <I>C. tricuspidata</I> were significantly reduced compared to the untreated group (<I>P</I> < 0.05). These results suggest that <I>C. tricuspidata</I> leaves may be useful for the treatment of obesity.</P>