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- 저자 : Jun Murayama (검색결과 3 건)
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Murayama, Harunobu,Shin, Ryong-Woon,Jun, Higuchi,Shibuya, Satoshi,Muramoto, Tamaki,Kitamoto, Tetsutuki 한림대학교 환경·생명과학연구소 2002 [일송 국제심포지엄] 노화와 만성퇴행성 신경질환 Vol.- No.4
To demonstrate that aluminum Ⅲ (AI) interacts with PHFτ in neurofibrillary degeneration (NFD) of Alzheimer's disease (AD) brain, we developed a "chelating autoclave method" that allows AI chelation by using trivalent-cationic chelator desferrioxamine. Its application to AD brain sections before Morin histochemistry for AI attenuated the positive fluorescence of neurofibrillary tangles, indicating AI removal from them. This method, applied for immunostaining with phosphorylation-dependent anti-τ antibodies, significantly enhanced the PHFτ immunoreactivity of the NFD. These results suggest that each of the phosphorylated epitopes in PHFτ are partially masked by AI binding. Incubation of AD sections with AICI_3 before Morin staining revealed AI accumulation with association to neurofibrillary tangles. Such incubation before immunostaining with the phosphorylation-dependent anti-τ antibodies abolished the immunolabeling of the NFD and this abolition was reversed by the AI chelation. These findings indicate cumulative AI binding to and thereby antigenic masking of the phosphorylated epitopes of PHFτ. AI binding was further documented for electrophoretically-resolved PHFτ on immunoblots, indication direct AI binding to PHFτ. In vitro aggregation by AICI_3 was observed for PHFτ but was lost on dephosphorylation of PHFτ. Taken together, phosphorylation-dependent and direct PHFτ-AI interaction occurs in the NFD of the AD brain. (Am J Pathol 1999, 155:877-885)
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Social work for vulnerable and marginalized people during COVID‐19 in Japan
Murayama Yoh,Hasebe Masami,Yamazaki Sachiko,Yamaguchi Jun,Kobayashi Erika 한국사회복지학회 2023 Asian Social Work and Policy Review Vol.17 No.3
During the Coronavirus disease pandemic (COVID‐19), working conditions became increasingly difficult for social workers, as they had to deal with new challenges and added workloads. This study describes the difficulties faced by social workers of the Self‐Reliance Support System in Japan and clarifies the solution for each difficulty while conducting their duties to support vulnerable people during COVID‐19. To this end, we conducted an open‐ended questionnaire survey and an interview survey. The data were analyzed using qualitative coding. The results showed that the difficulties faced in consultation support work included supporting hitherto socially invisible groups such as sole traders and foreigners. Social workers also faced an ethical dilemma, as they could not provide support to clients who “did not try to solve their problems” or for whom “interventional attempts did not lead to counseling support” and who only sought benefits at the risk of becoming isolated and impoverished. Following this, consultants collaborated to resolve such difficulties while maximizing the use of various local resources. The study's findings clarify that it would be effective to understand the difficulties faced by social workers to obtain hints toward their resolution.
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Kazuaki Oyake,Yasuto Baba,Yuki Suda,Jun Murayama,Ayumi Mochida,Yuki Ito,Honoka Abe,Kunitsugu Kondo,Yohei Otaka,Kimito Momose 대한재활의학회 2021 Annals of Rehabilitation Medicine Vol.45 No.4
Objective To examine the relationship between the time constant of oxygen uptake kinetics during the onset of exercise (τVO2) estimated from a single exercise bout and that obtained from three averaged exercise bouts in individuals with stroke. Methods Twenty participants with stroke performed three bouts of a constant-load pedaling exercise at approximately 80% of the workload corresponding to the ventilatory threshold to estimate τVO2. The VO2 data from the first trial of three bouts were used to estimate τVO2 for a single bout. Additionally, data collected from three bouts were ensemble-averaged to obtain τVO2 for three averaged bouts as the criterion. Results There was a very high correlation between τVO2 for a single bout (34.8±14.0 seconds) and τVO2 for three averaged bouts (38.5±13.4 seconds) (r=0.926, p<0.001). However, τVO2 for a single bout was smaller than that for three averaged bouts (p=0.006). Conclusion τVO2 for a single bout could reflect the relative difference in τVO2 for three averaged bouts among individuals with stroke. However, it should be noted that τVO2 for a single bout may be underestimated compared to τVO2 for three averaged bouts.
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