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Kim Dong Kyu,Kwon Joon Ho,Han Kichang,Kim Man-Deuk,Kim Gyoung Min,Moon Sungmo,Park Juil,Won Jong Yun,Kim Hyung Cheol,Chun Sei Hyun,Choi Seung Myeon 대한영상의학회 2023 Korean Journal of Radiology Vol.24 No.5
Objective: To assess the safety and efficacy of balloon dilatation under dual guidance using fluoroscopy and bronchoscopy for treating bronchial stenosis following lung transplantation (LT), and to elucidate the factors associated with patency after the procedure. Materials and Methods: From September, 2012, to April, 2021, 50 patients (mean age ± standard deviation, 54.4 ± 12.2 years) with bronchial stenosis among 361 recipients of LT were retrospectively analyzed. The safety of balloon dilatation was assessed by evaluating procedure-related complications. Efficacy was assessed by evaluating the technical success, primary patency, and secondary patency. Primary and secondary cumulative patency rates were calculated using the Kaplan-Meier method. The factors associated with patency after the procedure were evaluated using multivariable Cox hazard proportional regression analysis. Results: In total, 65 bronchi were treated with balloon dilatation in 50 patients. The total number of treatment sessions was 277 and the technical success rate was 99.3% (275/277 sessions). No major procedure-related complications were noted. During the mean follow-up period of 34.6 ± 30.8 months, primary patency was achieved in 12 of 65 bronchi (18.5%). However, the patency rate improved to 76.9% (50 of 65 bronchi) after repeated balloon dilatation (secondary patency). The 6-month, 1-year, 3-year, and 5-year secondary patency rates were 95.4%, 90.8%, 83.1%, and 78.5%, respectively. The presence of clinical symptoms was a significant prognostic factor associated with reduced primary patency (adjusted hazard ratio [HR], 0.465; 95% confidence interval [CI], 0.220–0.987). Early-stage treatment ≤ 6 months (adjusted HR, 3.588; 95% CI, 1.093– 11.780) and prolonged balloon dilatation > 5 min (adjusted HR, 3.285; 95% CI, 1.018–10.598) were associated with significantly higher secondary patency. Conclusion: Repeated balloon dilatation was determined to be safe and effective for treating bronchial stenosis following LT. Early-stage treatment and prolonged balloon dilatation could significantly promote long-term patency.
Population dynamics of aphid species in Korean seed potato cultivation area over four decades
Juil Kim,Min Kwon 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.10
The world’s climate is changing. This can affect agricultural insects and the damage they cause by altering their ecology, behavior and habitats. Aphids are emerging as an indicator of climate change, and they are a good model for understanding these environmental changes, especially based on their migratory behavior. In this study, the occurrence of aphids in a seed potato field in Pyeongchang, Korea, was monitored daily using a yellow water pan trap from 1977 to 2017. During these 40 years, the annual migration fluctuations of the aphids were analyzed, with particular focus on four species known to vector potato viruses, Aphis gossypii, Aulacorthum solani, Macrosiphum euphorbiae, and Myzus persicae. It was found that, as time goes by, the start point of spring migration in these aphid species was getting earlier while the peak in autumn migration gradually moved to the winter season. Together with a mean annual temperature increase of 1.03 °C in Pyeongchang over the past four decades, there is a potential threat of expansion in the distribution of aphid species. that this temperature change could influence the aphid’s population changes in the Korean peninsula.
Juil Kim,Min Kwon,Srinivasan Ramasamy,David G. Heckel 한국응용곤충학회 2017 한국응용곤충학회 학술대회논문집 Vol.2017 No.10
The genus Diadegma is a well known parasitoid group in various lepidopteran insect such as Plutella xylostella andsome are known to have symbiotic virus. Previously we reported a novel ichnovirus as named Diadegma fenestrale Ichnovirus(DfIV, 62 segments, 247,238bp) from D. fenestrale which parasitized in the P. xylostella. Here we report another ichnovirus,DsIV from Taiwan strain of D. semiclausum which parasitized in the P. xylostella. Total 64 genomic segments were sequenced,185,053bp from DsIV. Two Ichnovirus showed high similarity in 99 regions in most of segments. We already confirmedintegration of DfIV genome segments into the chromosome from the P. xylostella via genome sequencing of the lepidopteranhost. Therefore some of recombination could be passible inside of the lepidopteran genome.
Juil Kim,David G. Heckel,Min Kwon 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.10
The cotton bollworm, Helicoverpa armigera is one of the most polyphagous and cosmopolitan pest species in world wide including Korea. It also showed high level of resistance against various types of insecticide. To set the integrated resistant management program, first, we tried to identify the insecticide resistant mechanism via transcriptome analysis of coding and non-coding RNAs using 4 strains (Australian susceptible and resistant strains, Korean and Brazilian resistant strains, additional a sub-lethal dose insecticide treatment in Korean resistant strain). From the illumina based RNAseq data sets with genome information, some resistant involved detoxification genes and long non-coding RNAs were discovered. Second, following molecular markers were developed from resistant strain specific amino acid substitution from those candidate genes. Third, functionally identified genes’ markers were applied in field populations using some molecular diagnostic tools such as LAMP (loop mediated isothermal amplification). Now additional functional analysis is going on for these un-characterized candidate genes and long non-coding RNAs.