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Microfluidic platform for angiogenesis and vascular fusion
연주헌(Ju Hun Yeon),호청평(Qing Ping Hu),전누리(Noo Li Jeon) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.11
Angiogenesis and vascular fusion is a complex cellular process which has an essential role in tumor growth, tumor metastasis and other pathological processes. Various in vivo and in vitro models have been developed for studying angiogenesis and anastomosis. In vivo models, the observation of angiogenesis is technically difficult and observed effects are also difficult to quantify. For this reason, the compound screening for angiogenesis on in vivo models was limited and the development of angiogenesis research was restrained. Recently, several in vitro models have been attempted to recreate the complex sequence of events of angiogenesis with varying degrees of success. However, the formation of new blood vessels and blood vessel fusion were not attempted to study in vitro models because it was not proved the appropriate model for angiogenesis and vascular fusion. In this study, we developed a novel microfluidic platform using the appropriate micro-architecture and 3D gel for mimicking angiogenesis. This device demonstrates its capability to precise control the cellular environment, the direction of vessel growth and the distribution of new vessels. Microfluidic platform for angiogenesis and vascular fusion will improve the study about specific vascular fusion and will be beneficial to quantitative angiogenesis assay in further research.
Self-organized 3D Vessel Formation Spatially Guided By Surface Micropattern
Yekyung Cho(조예경),Sudong Kim(김수동),Ju Hun Yeon(연주헌),Noo Li Jeon(전누리) 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.10
Blood vessel formation is an essential event for various researches like cancer metastasis and wound healing. Although it has been developed the method of blood vessel formation in vitro with microbead or microfluidic structure, those were not easy to observe the effect of drugs on blood vessels with highthroughput screening. And a formation of vessel networks which are an important characteristic of blood vessels could not be generated or regulated using those methods. From these reasons, it is needed to develop a novel platform which is possible to design various geometry and network for high-throughput drug screening on blood vessels. In this study, we developed a novel high-throughput assay for generating blood vessel networks three-dimensionally using hydro gel on the 2D patterned endothelial cells. Through this method, the size and number of blood vessel can be regulated and the high-throughput drug screening on blood vessels can be performed against a lot of drug candidates.