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Jiyeon Lim,Yunhee Lee,Sangah Shin,Hwi-Won Lee,Claire E Kim,Jong-koo Lee,Sang-Ah Lee,Daehee Kang 한국영양학회 2018 Nutrition Research and Practice Vol.12 No.3
BACKGROUND/OBJECTIVES: Diet quality scores or indices, based on dietary guidelines, are used to summarize dietary intake into a single numeric variable. The aim of this study was to examine the association between the modified diet quality index for Koreans (DQI-K) and mortality among Health Examinees-Gem (HEXA-G) study participants. SUBJECTS/METHODS: The DQI-K was modified from the original diet quality index. A total of 134,547 participants (45,207 men and 89,340 women) from the HEXA-G study (2004 and 2013) were included. The DQI-K is based on eight components: 1) daily protein intake, 2) percent of energy from fat, 3) percent of energy from saturated fat, 4) daily cholesterol intake, 5) daily whole-grain intake, 6) daily fruit intake, 7) daily vegetable intake, and 8) daily sodium intake. The association between all-cause mortality and the DQI-K was examined using Cox proportional hazard regression models. Hazard ratios and confidence intervals were estimated after adjusting for age, gender, income, smoking status, alcohol drinking, body mass index, and total energy intake. RESULTS: The total DQI-K score was calculated by summing the scores of the eight components (range 0-9). In the multivariable adjusted models, with good diet quality (score 0-4) as a reference, poor diet quality (score 5-9) was associated with an increased risk of all-cause mortality (hazard ratios = 1.23, 95% confidence intervals = 1.06-1.43). Moreover, a one-unit increase in DQI-K score resulted in a 6% higher mortality risk. CONCLUSIONS: A poor diet quality DQI-K score was associated with an increased risk of mortality. The DQI-K in the present study may be used to assess the diet quality of Korean adults.
Serum persistent organic pollutants (POPs) and prostate cancer risk: A case-cohort study
Lim, Jung-eun,Nam, Chungmo,Yang, Jiyeon,Rha, Koon Ho,Lim, Kyung-Min,Jee, Sun Ha Elsevier 2017 International journal of hygiene and environmental Vol.220 No.5
<P><B>Abstract</B></P> <P>It is still unclear whether persistent organic pollutants (POPs) exposure increases the prostate cancer incidence risk. This prospective cohort study evaluated the associations between serum POPs concentrations and prostate cancer risk.</P> <P>Within a case-cohort study, we identified 110 people diagnosed with prostate cancer and randomly selected 256 sub-cohort participants without prostate cancer. Serum concentrations of 32 polychlorinated biphenyl (PCB) congeners and 19 organochlorine pesticides (OCPs) were measured. The hazard ratios (HRs) and 95% confidence interval (95% CI) for determining the associations between POPs and risk of prostate cancer were estimated using the weighted Cox regression model.</P> <P>Compared to the lowest tertile, increased risks of prostate cancer incidence were observed in the upper tertile of following PCBs: the moderately chlorinated (HR: 4.19; 95% CI: 1.30–13.54), the highly chlorinated (HR: 4.14; 95% CI: 1.75–9.79), biologically persistent as CYP1A and CYP2B inducers (HR: 4.44; 95% CI: 1.33–14.83), the sum of non- dioxin-like (HR: 3.47; 95% CI: 1.21–9.98), and ∑PCBs (HR: 4.29; 95% CI: 1.52–12.08). In dose-response curves, ∑PCBs was associated with the increased risk of prostate cancer.</P> <P>Our findings suggested a possible role of POPs in the etiology of prostate cancer.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The association of POPs and prostate cancer incidence risk was evaluated. </LI> <LI> Serum levels of PCBs and OCPs were measured. </LI> <LI> Both linear and non-linear analyses were conducted. </LI> <LI> PCBs and TEQ were associated with the increased risk of prostate cancer. </LI> <LI> Total OCPs was not associated with the prostate cancer risk. </LI> </UL> </P>
Lim, Jiyeon,Choi, Wonjung,Mok, Junghoon,Seo, Yongwon Elsevier 2019 CHEMICAL ENGINEERING JOURNAL -LAUSANNE- Vol.369 No.-
<P><B>Abstract</B></P> <P>Upgrading CO<SUB>2</SUB>-rich natural gas or biogas through CO<SUB>2</SUB> capture is essential to reduce greenhouse gas emissions and to increase its energy density. In this study, clathrate-based CO<SUB>2</SUB> capture from CO<SUB>2</SUB>-rich natural gas or biogas was investigated with a primary focus on kinetic CO<SUB>2</SUB> selectivity. The time-dependent CO<SUB>2</SUB> selectivity during clathrate formation for pure water, tetrahydrofuran (THF, 5.6 mol%) solution, and tetra-n-butylammonium chloride (TBAC, 3.3 mol%) solution was examined through direct composition analysis and <I>in situ</I> Raman spectroscopy. In pure water, the CO<SUB>2</SUB> composition in the clathrate phase was much higher at the early stage of clathrate formation than that at equilibrium, indicating that CO<SUB>2</SUB> is kinetically and thermodynamically selective. For both the THF (5.6 mol%) and TBAC (3.3 mol%) solutions, the CO<SUB>2</SUB> composition in the clathrate phase was almost constant during clathrate formation. However, the TBAC (3.3 mol%) solution showed significantly higher CO<SUB>2</SUB> composition (∼74%) throughout the reaction, whereas the THF (5.6 mol%) solution exhibited enrichment of CH<SUB>4</SUB> in the clathrate phase. The experimental results clearly demonstrate that CO<SUB>2</SUB> selectivity is dependent on both kinetics and equilibrium of clathrate hydrates and that the addition of thermodynamic promoters, such as THF and TBAC, can affect kinetic CO<SUB>2</SUB> selectivity as well as equilibrium CO<SUB>2</SUB> selectivity in the clathrate phase.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Clathrate growth kinetics and time-dependent CO<SUB>2</SUB> selectivity were investigated. </LI> <LI> At the early stage of clathrate formation in pure water, CO<SUB>2</SUB> selectivity was higher. </LI> <LI> Clathrate CO<SUB>2</SUB> composition was not changed during THF and TBAC clathrate formation. </LI> <LI> CO<SUB>2</SUB> selectivity was dependent on both the kinetics and equilibrium of clathrates. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Deeper Integrative Neural Network Analysis for Multi-level Omics Data
Jayeon Lim,Junsang Cho,JaeYoung Kim,Jiyeon Kim,SungHwan Kim 계명대학교 자연과학연구소 2019 Quantitative Bio-Science Vol.38 No.2
Recently, various machine learning methods have emerged for analyzing and interpreting the ever-expanding genetic data. In addition, new analytical tools for machine learning using statistical models, are being developed. Lim et al. [1] proposed the integrative deep learning to find the differentially expressed (DE) biomarkers using deep neural network with a single hidden layer. This method consists of the input layer, a hidden layer, the consolidation layer, and the output layer. They found that integrative deep learning method is stable and robust for analysis of the variation in the simulation datasets. In this study, we expanded the integrative deep learning method by including an additional hidden layer. The present expanded method consists of the input layer, two hidden layers, the consolidation layer and the output layer. The purpose of this study is to investigate the effect of the additional hidden layers on the performance of the previous method (integrative deep learning). We conducted a simulation study and compared the results with those from deep neural network with one hidden layer.
실내금연법 실시가 실내환경, 건강, 흡연행태에 미치는 영향
이지연(Jiyeon Lee),임완령(Wanryung Lim),김정윤(Joung Yoon Kim),손홍지(Hongji Sohn),임수길(Soogil Lim),이기영(Kiyoung Lee) 한국실내환경학회 2008 한국실내환경학회지 Vol.5 No.3
Secondhand smoke (SHS) is one of major public health threats in morbidity and mortality. Several national and regional comprehensive smoke-free regulations have been implemented to prevent public health exposure, but not in Korea. The purpose of this manuscript was to review impacts of the national or regional smoke-free legislations on indoor air quality, health effects and smoking behaviors. Indoor air quality has been improved significantly after smoke free policy. Such improvement was measured by fine particulates and urinary cotinine. Respiratory and cardiovascular health effects were significantly improved after smoke free policy. This is an indirect evidence of association between secondhand smoke exposure and the health effects. Respiratory symptoms were improved as short as one month after smoke free policy. Smoke free policy was also associated with improved perception of danger of secondhand smoke. Reduction of smoking prevalence was also unexpected benefit of smoke free policy. As reviewed in this paper, smoke free policy can be beneficial to indoor air quality, health effects and smoking behaviors. Since Korea does not have comprehensive smoke free policy yet, it is strongly recommended to implement national comprehensive smoke free policy.