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Kim, Young Il,Kim, Kyung Won,Lee, Han Kyu,Park, Jisuk,Chung, Jin Wook,Youn, Hyewon,Kim, Soo Jin,Kim, Dal-Hyun,Tseng, Jen-Chieh,Lee, Jeong Min Potamitis Press 2014 Anticancer research Vol.34 No.4
<P>To evaluate the anticancer efficacy of CKD-516, a novel vascular-disrupting agent, alone and in combination with doxorubicin in the treatment of hepatocellular carcinoma (HCC).</P>
Terahertz dynamic imaging of skin drug absorption.
Kim, Kyung Won,Kim, Kwang-Sung,Kim, Hyeongmun,Lee, Sang Hun,Park, Jae-Hak,Han, Ju-Hee,Seok, Seung-Hyeok,Park, Jisuk,Choi, YoonSeok,Kim, Young Il,Han, Joon Koo,Son, Joo-Hiuk Optical Society of America 2012 Optics express Vol.20 No.9
<P>Terahertz (THz) imaging is a nondestructive, label-free, rapid imaging technique which gives the possibility of a real-time tracing of drugs within the skin. We evaluated the feasibility of THz dynamic imaging for visualizing serial changes in the distribution and penetration of a topical agent, dimethyl sulfoxide (DMSO) containing ketoprofen, using excised mouse skins. THz imaging was performed for 6 h after drug application to the skin and was compared with the results obtained using the Franz cell diffusion test, a standard in vitro skin absorption test. THz dynamic reflection imaging showed that the reflection signals decreased rapidly during the early time period, and remained constant through the late time period. The area of drug permeation within the skin layer on THz imaging increased with time. The dynamic pattern of THz reflection signal decrease was similar to that of DMSO absorption analyzed by the Franz cell diffusion test, which indicates that THz imaging mainly reflects the DMSO component. This study demonstrates that THz imaging technique can be used for imaging the spatial distribution and penetration of drug-applied sites.</P>
KIM, SEONG-KYU,KIM, SEONG-HO,NAH, SEONG-SU,LEE, JI HYUN,HONG, SEUNG-JAE,KIM, HYUN-SOOK,LEE, HYE-SOON,KIM, HYOUN AH,JOUNG, CHUNG-IL,BAE, JISUK,CHOE, JUNG-YOON,LEE, SHIN-SEOK Journal of Rheumatology 2013 The Journal of rheumatology Vol.40 No.3
<P><B>Objective.</B></P><P>Guanosine triphosphate cyclohydrolase 1 (GCH1) is the rate-limiting enzyme in the synthesis of tetrahydrobiopterin, which is an essential cofactor in nitric oxide (NO) production. Polymorphisms in the <I>GCH1</I> gene have been implicated in protection against pain sensitivity. The aim of our study was to determine whether single-nucleotide polymorphisms (SNP) in the <I>GCH1</I> gene affect susceptibility and/or pain sensitivity in fibromyalgia syndrome (FM).</P><P><B>Methods.</B></P><P>A total of 409 patients with FM and 422 controls were enrolled. The alleles and genotypes at 4 positions [rs3783641(T>A), rs841(C>T), rs752688(C>T), and rs4411417(T>C)] in the <I>GCH1</I> gene were analyzed. The associations of the <I>GCH1</I> SNP with susceptibility and clinical measures in patients with FM were assessed.</P><P><B>Results.</B></P><P>The frequencies of alleles and genotypes of the 4 SNP did not differ between patients with FM and healthy controls. Among 13 constructed haplotypes, we further examined 4 (CCTT, TTCT, TTCA, and CCTA) with > 1% frequency in both FM and controls. No associations of <I>GCH1</I> polymorphisms with FM-related activity or severity indexes were found, although the number and total score of tender points in patients with FM differed among the 4 haplotypes (p = 0.03 and p = 0.01, respectively). The CCTA haplotype of <I>GCH1</I> was associated with significantly lower pain sensitivity and occurred less frequently than the CCTT haplotype in patients with FM (p = 0.04, OR 0.45, 95% CI 0.21–0.96).</P><P><B>Conclusion.</B></P><P>Our study provides evidence that certain <I>GCH1</I> haplotypes may be protective against susceptibility and pain sensitivity in FM. Our data suggest that NO is responsible for pain sensitivity in the pathogenesis of FM.</P>
Design of an aerodynamic load simulator for pintle actuators
Jisuk Kim,한승철,강대겸,이하준 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.8
In this study, a novel aerodynamic load simulator design for a pintle actuator is proposed. The proposed load simulator is composed of two ring magnets magnetized along their geometric axes and a ferromagnetic disk between them. The net magnetic force on the disk is transmitted by a nonmagnetic rod that is attached to the disk and moves through the ring magnets’ internal holes. The force is then amplified by a lever between the rod and actuator. The size of the disk, size of the magnets, size of the magnet brackets, and fixed distance between the two magnets are parameterized to reproduce a target load profile using finite element method magnetics (FEMM) software. The FEMM results show that the net force profile along the disk’s position is similar to the target load profile according to the computational fluid dynamics (CFD) analysis results of pintle’s operating conditions. Based on the FEMM results, all parts of the load generating unit are machined and assembled to build a prototype of the aerodynamic load simulator for the pintle actuator. The test results of the developed magnetbased load simulator are compared with FEMM results and with the test results of a conventional spring-based load simulator to verify the effectiveness of the developed load simulator.