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Echinacoside Prevents Sepsis-Induced Myocardial Damage via Targeting SOD2
Jingxiang Wu,Xingji You,Xin Li,Zuojing Zhang,Xiaoxuan Zhang,Yibo Yin,Xinru Yuan 한국식품영양과학회 2024 Journal of medicinal food Vol.27 No.2
Echinacoside (ECH) is a prominent naturally occurring bioactive compound with effects of alleviatingmyocardial damage. We aimed to explore the beneficial effects of ECH against sepsis-induced myocardial damage andelucidate the potential mechanism. Echocardiography and Masson staining demonstrated that ECH alleviates cardiac functionand fibrosis in the cecal ligation and puncture (CLP) model. Transcriptome profiling and network pharmacology analysisshowed that there are 51 overlapping targets between sepsis-induced myocardial damage and ECH. Subsequently, chemicalcarcinogenesis-reactive oxygen species (ROS) were enriched in multiple targets. Wherein, SOD2 may be the potential targetof ECH on sepsis-induced myocardial damage. Polymerase chain reaction results showed that ECH administration couldmarkedly increase the expression of SOD2 and reduce the release of ROS. Combined with injecting the inhibitor of SOD2, thebeneficial effect of ECH on mortality, cardiac function, and fibrosis was eliminated, and release of ROS was increased afterinhibiting SOD2. ECH significantly alleviated myocardial damage in septic mice, and the therapeutic mechanism of ECH isachieved by upregulating SOD2 which decreased the release of ROS.
( Yanling Quan ),( Lin Wang ),( Yisheng Liu ),( Jingxiang Cong ),( Shengquan Xie ),( Xiuhong Wu ) 한국화학공학회 2015 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.53 No.3
Plackett-Burman (PB) and Box-Behnken (BB) experimental designs were used to optimize fermentation variables for the biotransformation of glycyrrhizin (GL) to monoglucuronyl-glycyrrhetinic acid (MGGA). The PB design was first used to screen the important factors among the medium variables. The steepest ascent method was used to approach the optimum range for each of these factors. The BB design was finally used to analyze the response surfaces of the screened factors for further optimization. The optimized conditions for this system were 0.7 g/L MgSO4·7H2O, 1.19 g/L GL, and cultivation for six days. The biotransformation of GL to MGGA could reach up to 35.72%, which is a good result for this kind of transformation.
Supercapacitive behavior of mesoporous carbon CMK-3 in calcium nitrate aqueous electrolyte
Heming Luo,Deyi Zhang,Liwen Zheng,Longyan Lei,Jingxiang Wu,Jian Yang 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.4
Calcium nitrate Ca(NO3)2 aqueous solution was found to be an effective aqueous electrolyte for a supercapacitorusing ordered mesoporous carbon as the electrode materials. The supercapacitive behavior of ordered mesoporouscarbon CMK-3 electrode in Ca(NO3)2 aqueous electrolyte was investigated utilizing cyclic voltammetry (CV),electrochemical impedance spectroscopy (EIS), and galvanostatic charge/discharge measurements. CMK-3 electrodeshows excellent supercapacitive behavior with wide voltage window, high specific gravimetric capacitance and satisfactoryelectrochemical stability in Ca(NO3)2 aqueous electrolyte. The specific gravimetric capacitance of CMK-3 electrodein Ca(NO3)2 aqueous electrolyte reaches 210 F g−1 at a current density of 1 A g−1, which is higher than that in conventionalaqueous electrolytes NaNO3 and KOH solution about 40% and 54%, respectively. The high charge density of the electricdouble layer formed at the interface of the CMK-3 electrode and Ca(NO3)2 aqueous electrolyte and the pseudo-capacitiveeffect originating from the oxygen groups on the surface of CMK-3 were believed to respond for the excellent supercapacitivebehavior of CMK-3 electrode in Ca(NO3)2 aqueous electrolyte.
Jing Xiang,Tian-Tian Yang,Lu-Lu Fu,Ya Luo,Jia-Shou Wu 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.9
The reactions of hydrated CdCl2, MnCl2, and NiCl2 with 2,2'-bipyidine-3,3',6,6'-tetracarboxylic acid (H4bptc) afforded the mononuclear [CdII(H2bptc)(H2O)3]·H2O (1), linear {[Cd(H2bptc)(H2O)]·3H2O}n (2), 3-D heterobimetallic [NaCd(Hbptc)(H2O)] (3), layer [Mn(H2bptc)(H2O)]n (4) and a dinuclear compound [Ni2(H2bptc)- (H2O)2]·6H2O (5). These compounds have been characterized by elemental analysis, IR, and their structures have been determined by X-ray crystallography. The thermal stabilities of 1-3 were measured by thermogravimetric analysis (TGA) and their solid state luminescence properties together with the free ligand H4bptc were investigated at room temperature.