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Hu, Jin-Ryul,Choi, Beom-Rak,Park, Hye-Rim,Sung, Mi-Sun,Yi, Hae-Yeon,Kang, Su-Jin,Ku, Sae-Kwang,Lee, Young-Joon The Society of Korean Medicine 2016 대한한의학회지 Vol.37 No.4
Objectives: The aim of this study was to solve skin moisturizing action mechanism issues of pomegranate concentrated solution (PCS) and dried pomegranate concentrate powder (PCP), at least partially. Materials and methods: In this study, ceramide and $TGF-{\beta}1$ contents with $TGF-{\beta}1$ mRNA expressions were analysis on the skin tissue homogenate samples after 56 days of continuous oral administration of PCS 1, 2, and 4 ml/kg, and PCP 100, 200 and 400 mg/kg. Results: Noticeable and dose-dependent increases of skin $TGF-{\beta}1$ contents and mRNA expressions were demonstrated in all PCP and PCS treated mice as compared with intact vehicle control, but no significant changes on the skin ceramide contents were demonstrated in all PCP and PCS treated mice as compared with intact vehicle control, in the current study. In addition, PCP 200 mg/kg showed similar increases of the skin $TGF-{\beta}1$ contents and mRNA expressions as compared to those of PCS 4 ml/kg. Conclusions: The presented results suggested that in vivo skin moisturizing effects of PCP and PCS after oral administration through up regulation of hyaluronan synthesis demonstrated in our previous results, may be possibly mediated by modulation of $TGF-{\beta}1$ expressions at least partially, without critical influences on the skin ceramide contents.
Hu, Jin-Ryul,Jang, Tae-Woo,Kang, Su-Jin,Ku, Sae-Kwang,Choi, Seong-Hun,Lee, Young-Joon The Society of Korean Medicine 2019 대한한의학회지 Vol.40 No.4
Objectives: Here, we investigated the effects of concentrated and lyophilized powders Blue honeysuckle (BH) on the PK of tamoxifen, to establish the pharmacokinetics (PK) profiles as one of essential process in new drug development. Methods: After single oral treatment of 0.4 mg/ml of tamoxifen or tamoxifen 0.4 with BH 40, 20 and 10 mg/ml, the plasma were collected at 0.5 hr before administration, 0.5, 1, 2, 3, 4, 6, 8 and 24 hr after end of single or mixed formula treatment. Plasma concentrations of tamoxifen were analyzed using LC-MS/MS methods. Tmax, Cmax, AUC, t1/2 and MRTinf were analyzed using noncompartmental PK data analyzer programs. Results: Tamoxifen and BH 40 mg/ml did not induce any significant change on the plasma tamoxifen concentrations, while significant decreases were observed in tamoxifen and BH 10 mg/ml from 2 to 8 hr as compared with tamoxifen only, respectively. Furthermore, significant increases of Tmax in tamoxifen and BH 40 mg/ml, significant decreases of Cmax in tamoxifen and BH 20 mg/ml, significant decreases of AUC0-t, AUC0-inf and MRTinf in tamoxifen and BH 10 mg/ml were demonstrated as compared with tamoxifen only. Conclusion: Taken together, tamoxifen and BH 10 mg/ml induced significant decrease of the oral bioavailability of tamoxifen, while tamoxifen and BH 40 or 20 mg/ml did not critically influenced, suggesting formulated BH concentration-independencies. It, therefore, seems to be needed that pharmacokinetic study after repeated administration should be tested to conclude the effects of BH on the pharmacokinetics of tamoxifen.
PDP 격벽제작을 위한 롤-프레싱 공정에서의 유한요소해석을 통한 공정변수 분석에 관한 연구
류승민(Seung-Min Ryu),박상후(Sang Hu Park),이석렬(Seok-Ryul Lee),홍진태(Jin Tae Hong),양동열(Dong-Yol Yang) 대한기계학회 2006 대한기계학회 춘추학술대회 Vol.2006 No.6
Plasma Display Panel (PDP) is considered as one of the most popular flat panel displays due to its characters such as wide screen area, thin thickness, and wide angle of view. However, there are still remained problems should be solved to improve the efficiency of consuming power, and many works have been conducted to change the structure of barrier-ribs in the PDP for improving its efficiency. Generally, enlarging the coating space of phosphors and the discharging space of the ribs is the way to improve the efficiency. In this work, a roll-pressing process has been proposed with various rolling paths to fabricate highly efficient rib as closed types such as rectangular shape for HDTV. Also, the finite element method was employed to analysis the process parameters and to optimize them. Through this work, some kinds of barrier-ribs were fabricated using the proposed process, and optimal conditions were estimated.
Hard X-ray free-electron laser with femtosecond-scale timing jitter
Kang, Heung-Sik,Min, Chang-Ki,Heo, Hoon,Kim, Changbum,Yang, Haeryong,Kim, Gyujin,Nam, Inhyuk,Baek, Soung Youl,Choi, Hyo-Jin,Mun, Geonyeong,Park, Byoung Ryul,Suh, Young Jin,Shin, Dong Cheol,Hu, Jinyul Springer Science and Business Media LLC 2017 Nature photonics Vol.11 No.11
<P>The hard X-ray free-electron laser at the Pohang Accelerator Laboratory (PAL-XFEL) in the Republic of Korea achieved saturation of a 0.144 nm free-electron laser beam on 27 November 2016, making it the third hard X-ray free-electron laser in the world, following the demonstrations of the Linac Coherent Light Source (LCLS) and the SPring-8 Angstrom Compact Free Electron Laser (SACLA). The use of electron-beam-based alignment incorporating undulator radiation spectrum analysis has allowed reliable operation of PAL-XFEL with unprecedented temporal stability and dispersion-free orbits. In particular, a timing jitter of just 20 fs for the free-electron laser photon beam is consistently achieved due to the use of a state-of-the-art design of the electron linear accelerator and electron-beam-based alignment. The low timing jitter of the electron beam makes it possible to observe Bi(111) phonon dynamics without the need for timing-jitter correction, indicating that PAL-XFEL will be an extremely useful tool for hard X-ray time-resolved experiments.</P>