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Jikang Yoo,Yongseog Chung,Cheol-Hee Choi,Bok Hee Kim,조훈,Hyun-Suk Choi 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.2
A series of nine new compounds bridged by acyl groups at the 5,8-dihydroxyl group of DHNQ were synthesized and their cytotoxic activity against L1210 and P388 cancer cells was examined. Their antitumor action in mice bearing S-180 cells in the peritoneal cavity was also assessed. Increasing the size of the acyl group (compounds 7-9) up to propyl increased the antitumor activity (T/C value), whereas the cytotoxicity of these compounds was comparable against L1210 (lymphocytic leukemia) and P388 (lymphoid neoplasm) cancer cells. Further increasing in the chain length (compounds 11-15) decreased the potency. Thus, acyl group chains of three carbon atoms is optimal for antitumor activity. The most potent compound of this series was 2-[N-methyl-N-(4-methyl-1,3-benzothiazol-2-yl)aminomethyl]-5,8-dipropylcarbonyloxy- 1,4-naphthoquinone (compound 9) with a T/C (%) value of 354.
Synthesis and Properties of Semi-Rigid Polymer
Yoo, JiKang,Suh, HyoSuk CHOSUN UNIVERSITY 1997 Basic Science and Engineering Vol.1 No.2
The blend of a liquid crystalline polymer(LCP) and a modified poly(butylene terephathalate)(MPBT) was prepared to study the their phyical properties. Thermal, optical and morphological properties were examined by differential scanning calorimetry(DSC), optical microscopy and scanning electron microscopy(SEM). Melting temperatures were 168℃ for LCP(HAP) and 191℃ for MPBT, respectively. The isotropizatio temperature for HAP was 298℃ which gave wide liquid crystalline temperature range of 130℃. The LCP(HAP) in the melt showed the nematic mesophase identified by thread-like optical texture. The LCP domains in blend were found to be finely dispersed below 0.4㎛ in size.
한승택,유지강 조선대학교 생산기술연구소 2004 生産技術硏究 Vol.26 No.1
The oxadizole-containing acryl polymers are prepared by reacting dimethyl terephthalate with hydrazine monohydrate followed by cyclodehydration, chain extension, reaction with acryloyl chloride and free radical polymerization. In this study, oxadiazole-containing acryl polymers having alkylene spacer such as ethylene or hexamethylene unit are synthesized and their luminescent properties as well as thermal and solubility properties are investigated. The both of oxadiazole-containing acryl polymers having ethylene(PC2-OXA) and hexamethylene(PC6-OXA) show the photoluminescence at 372nm in THF and around 385nm in a film state. In contrast, analog of PC6-0XA having dimethylarnino group at the end of pendant group(PC6-AOXA), designed to shift emission wavelength to visible range, shows the photoluminescence at about 500nm in THF or in a film state which corresponds to greenish-blue color. PC6-OXA and PC6-AOXA show good solubility in various organic solvents.
Synthesis and Evaluation of Antitumor Activity of Novel 1,4-Naphthoquinone Derivatives (IV)
Kim Bok Hee,Yoo Jikang,Park Si-Hyun,Jung Jae-Kyung,Cho Hoon,Chung Yongseog The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.2
1,4-Naphthoquinones are widely distributed in nature and many clinically important antitumor drugs containing a quinone moiety, such as anthracyclines, mitoxantrones and saintopin, show excellent anticancer activity. In this study, 2- or 6-substituted 5,8-dimethoxy-1,4-naphthoquinone (DMNQ) and 5,8-dihydroxy-1,4-naphthoquinone (DHNQ) derivatives were synthesized, and their cytotoxic activity against L1210 and P388 cancer cells was examined. Their antitumor activity was also assessed in mice bearing S-180 cells in the peritoneal cavity. In comparison with the DMNQ derivatives, the DHNQ derivatives exhibited more potent bioactivities than the DMNQ derivatives against both L1210 and P388 cells in vitro and S-180 cells in vivo. The $ED_{50}$ values of the DHNQ derivatives against P388 cells were in the range of 0.18-1.81 ${\mu}g/mL$ whereas those of the DMNQ derivatives were in the range of 0.26-40.41 ${\mu}g/mL$. The T/C ($\%$) values of the DHNQ derivatives, 8, 17, 18, 19, and 20, were found to be comparable to or even better than that of adriamycin. It was also observed that the 2-substituted derivatives (8, 19, 20) showed better antitumor activity than the 6-substituted derivatives (7, 17, 18) in the mice bearing S-180 cells in the peritoneal cavity.