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- 저자 : Jiangang Long (검색결과 3 건)
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Jia Long,Zixu Miao,Huihuang Chen,Rongdong Deng,Weiran Zuo,Bao Guo,Jiangang Ku 한국자기학회 2020 Journal of Magnetics Vol.25 No.1
Chain-like and diamond-shaped magnetic particle agglomeration (MPA) commonly forming in a weak magnetic field are simulated based on the finite element method (FEM), and the effects of particle diameter, magnetic field strength, particle relative magnetic permeability, and particle number in magnetic particle chains (MPCs) and diamond-shaped MPA on the strength of MPA are analysed in detail. The results show that magnetic forces on the centre contact points (CCPs) of MPA are positively correlated with the particle diameter, magnetic field strength, particle relative magnetic permeability, and particle number. In addition, the forces on the CCPs of the MPCs (N=2) have a square relationship with the particle diameter and magnetic field strength and have a power relationship of 1.25 with the particle relative magnetic permeability. The forces on each contact point decrease slowly from the centre to both ends in the MPCs and then rapidly decrease to one value (approximately 0.779 times the forces on the CCPs). As for the diamond-shaped MPA, with the increase in the angle α between the magnetic field and axis of diamond-shaped MPA, the force magnitude of the particle entrained parallelly in the diamond-shaped MPA shows a trend of a “cosine curve” shape and the minimum value is 2109 times that of the entrained particle’s gravity. The angle θ between the direction of the force and the negative X-axis shows a trend of a “sine curve” shape. When α = 25° and 155°, the angle θ of the force on the entrained particle reaches an extreme value, that is, θ = 21.87°. Only if the angle θ reaches 30º can the particle entrained parallelly escape from the diamond-shaped MPA. Thus, the diamond-shaped MPA remains in a stable state and it is difficult to disperse MPA by changing the direction of the magnetic field.
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Gao, Meili,Li, Yongfei,Xue, Xiaochang,Long, Jiangang,Chen, Lan,Shah, Walayat,Kong, Yu Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6
This study was to undertaken to investigate the impacts of AhR, CYP1A1, GSTM1 genetic polymorphisms on the R273G mutation in exon 8 of the tumor suppressor p53 gene (TP53) among polycyclic aromatic hydrocarbons (PAHs) exposed to coke-oven workers. One hundred thirteen workers exposed to PAH and 82 control workers were recruited. We genotyped for polymorphisms in the AhR, CYP1A1, GSTM1, and TP53 R273G mutation in blood by PCR methods, and determined the levels of 1-hydroxypyrene as PAH exposure marker in urine using the high pressure liquid chromatography assay. We found that the distribution of alcohol users and the urinary excretion of 1-OHP in the exposed workers were significantly higher than that of the control workers (p=0.004, p<0.001, respectively). Significant differences were observed in the p53 genotype distributions of smoking subjects (p=0.01, 95%CI: 1.23-6.01) and PAH exposure (p=0.008, 95%CI: 1.24-4.48), respectively. Further, significant differences were observed in the p53 exon 8 mutations for the genetic polymorphisms of Lys/Arg for AhR (p=0.02, 95%CI: 0.70-15.86), Val/Val for CYP1A1 (p=0.04, 95%CI: 0.98-19.09) and null for GSTM1 (p=0.02, 95%CI: 1.19-6.26), respectively. Our findings indicated that polymorphisms of PAH metabolic genes, such as AhR, CYP1A1, GSTM1 polymorphisms may interact with p53 genetic variants and may contribute to PAH related cancers.
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Liao Chang,Xin Liu,Jing Liu,Hua Li,Yanshen Yang,Jia Liu,Zihao Guo,Ke Xiao,Chen Zhang,Jiankang Liu,Xi Zhao-Wilson,Jiangang Long 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.3
Accumulating research has shown that chronic D-galactose (D-gal) exposure induces symptoms similar to natural aging in animals. Therefore, rodents chronically exposed to D-gal are increasingly used as a model for aging and delay-of-aging pharmacological research. Mitochondrial dysfunction is thought to play a vital role in aging and age-related diseases; however, whether mitochondrial dysfunction plays a significant role in mice exposed to D-gal remains unknown. In the present study, we investigated cognitive dysfunction, locomotor activity, and mitochondrial dysfunction involved in D-gal exposure in mice. We found that D-gal exposure (125 mg/kg/day, 8 weeks) resulted in a serious impairment in grip strength in mice, whereas spatial memory and locomotor coordination remained intact. Interestingly, muscular mitochondrial complex I deficiency occurred in the skeletal muscle of mice exposed to D-gal. Mitochondrial ultrastructure abnormality was implicated as a contributing factor in D-gal-induced muscular impairment. Moreover, three combinations (A, B, and C) of nutrients applied in this study effectively reversed D-gal-induced muscular impairment. Nutrient formulas B and C were especially effective in reversing complex I dysfunction in both skeletal muscle and heart muscle. These findings suggest the following: (1) chronic exposure to D-gal first results in specific muscular impairment in mice, rather than causing general, premature aging; (2) poor skeletal muscle strength induced by D-gal might be due to the mitochondrial dysfunction caused by complex I deficiency; and (3) the nutrient complexes applied in the study attenuated the skeletal muscle impairment, most likely by improving mitochondrial function.
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