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Sung Hwa Shin, Eun Jeoung Lee, Sunghee Hyun Dowonkyoung Park, Sang Sun Kang 충북대학교 과학교육연구소 2017 과학교육연구논총 Vol.32 No.2
Yes associated protein (YAP) and transcriptional co-activator with a PDZ-binding motif (TAZ) are both found in the cytoplasm as well as the nucleus, where they regulate gene transcriptions. YAP/TAZ nuclear localization is a crucial dterminant of their function. Phosphorylation by protein kinases is another major factor responsible for the YAP/TAZ subcellular localization, resulting in retention of YAP/TAZ in the cytoplasm. However, it is still nuclear as to how YAP is transported into toe nucleus. Using site directed mutagenesis and confocal microscopic analysis, we demonstrated in this study that the motif(lqmekerlrlkqqellrqamrninpstanspkcqelalrsqlpt)inYAP plays a role as the putative PY-NLS to which Karyopherin β2 (Kapβ2) bind to facilitate its nuclear localization. Thus, our observations have provided new clues to understand YAP regulating in Hippo signal transduction pathway by Kapβ2 binding.
난연가공된 섬유제품의 Polybrominated Diphenyl Ethers 분석
신정화(Jeoung Hwa Shin),이규건(Kyu Keon Lee),안윤경(Yun Gyong Ahn),나윤철(Yun-Cheol Na) 한국생활환경학회 2009 한국생활환경학회지 Vol.16 No.2
Brominated flame retardants(BFRs) have been widely used as additive or reactive chemical in polymers and textiles. An analytical methods for polybrominated diphenyl ethers (PBDEs) in textile samples using gas chromatography/mass spectrometry (GC/MS) and thermal desorption (TD)-GC/MS were described. Decabromodiphenyl ether (deca-BDE) in textiles was extracted using ultrasonification method with n-hexane/ methylene chloride (1:1, v/v) for GC/MS analysis. For purification, the absorbent of silica was applied to retain the impurities. Analysis of deca-BDE with TD-GC/MS, which is not required for extraction and clean up. In the monitoring of deca-BDE in textiles, TDGC/MS using the pyrolysis system which can be confirmed in the presence of deca-BDE in textiles is effective. This method have the advantage of rapid, simplicity, economy and small amount of sample, while conventional GC/MS method is needed a lot of time and high amount of solvent. However, the determination of low concentration of deca-BDE in textiles by GC/MS analysis is appropriate.