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- 저자 : Janice F. Wang-Polagruto (검색결과 1 건)
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Carl L. Keen,John A. Polagruto,Derek D. Schramm,Janice F. Wang-Polagruto,Luke Lee 한국식품영양과학회 2003 Journal of medicinal food Vol.6 No.4
Diets rich in flavonoids have been associated with reduced risk for cardiovascular disease. This may be due,in part, to flavonoid-induced alterations in eicosanoid synthesis. Our objective was to identify plant-derived beverages that al-ter synthesis of prostacyclin in cultured human aortic endothelial cells (HAEC), and to determine if these beverages could al-ter in vivo6-keto-prostaglandin F 1a (a stable metabolite of prostacyclin) synthesis and platelet function. HAEC were treatedwith nine commonly consumed beverages to determine their effects on prostacyclin synthesis under acute and chronic treat-ment regimens. Orange, purple grape, and pomegranate juices and coffee (6 9 mL/kg) were then provided to 28 fasted, healthyadult subjects (eight men and 20 women) on five separate days. Plasma samples were collected immediately following juiceconsumption (baseline), and at 2 and 6 hours post-consumption. On an acute basis, administration of HAEC with pomegran-ate juice increased media prostacyclin. Chronic exposure to purple grape and pomegranate juice increased aortic endothelialcell prostacyclin synthesis (38% and 61%, respectively; P, .05). The consumption of purple grape, pomegranate, and orangejuice prolonged epinephrine/collagen-induced clotting time (P, .05). Purple grape juice increased plasma 6-keto-prostaglandinF1a (20%; P, .05) at 2 hours; pomegranate and orange juice did not significantly influence plasma prostacyclin concentra-tions. Consistent with the in vitrodata, coffee consumption did not influence clotting time or plasma prostacyclin concentra-tions. These results indicate that the HAEC model system can provide a qualitative means to screen food and food-derivedproducts for biologic activity related to cardiovascular health.
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