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Floristic study of Jang-do (Isl.) in Korea
Son, Hyun-Deok,Gwon, Soon-Gyo,Jang, Jeong-Won,Sun, Eun-Mi,Kim, Byeol-Ah,Im, Hyoung-Tak The National Institute of Biological Resources 2013 Journal of species research Vol.2 No.2
We investigated the flora of Jang-do (Isl.), an island of the Heuksan archipelago, located in Heuksan-myeon, Shinan-gun, Jeollanam-do and discussed the remarkable plants found there. Thirteen-field trips (total 27 days) were completed from May of 2004 to May of 2013. As a result, we identified the distribution of 423 taxa in Jang-do (Isl.), comprising 104 families, 285 genera, 335 species, 78 varieties and 10 forms. There are a total of 95 taxa of floristic regional indicator plants. The floristic regional indicators are as follows; four taxa of level V such as Impatiens furcillata, four taxa of level IV such as Hosta yingeri, 14 taxa of level III such as Ophioglossum vulgatum, 5 taxa of level II, and 58 taxa of level I. In addition 10 red data plants, 2 vulnerable species (VU) including Calanthe striata for. sieboldii, and 4 least concern species (LC) like Ardisia crenata, 2 not evaluated species (NE) such as Hosta yingeri, were found in the investigated area. An unrecorded species, Fragaria (Rosaceae), was found in a forest of Jang-do (Isl.) for the first time in Korea.
Simulated Q-annealing: conformational search with an effective potential.
Son, Won-joon,Jang, Soonmin,Shin, Seokmin Springer 2012 Journal of molecular modeling Vol.18 No.1
<P>We have tested a version of the generalized simulated annealing algorithm based on molecular dynamics simulations with effective potential suggested by Tsallis statistics. The generalized annealing method, termed 'simulated Q-annealing (SQ),' is applied to the simulations of a synthetic 11-residue peptide segment (1AQG). In SQ, the energy barriers between local minima change as the parameter q is varied and specific degrees of freedom can be selectively heated up and annealed. Conformational dynamics obtained by ordinary simulated annealing (SA) and SQ simulations are compared in order to illustrate the effectiveness of the SQ approach in conformational searching. We show that SQ can navigate the potential energy surface efficiently with a simple annealing protocol and demonstrate that conformations sampled by SQ can represent the funnel-like free energy surface.</P>
Continuous monitoring of arthritis in animal models using optical imaging modalities
Son, Taeyoon,Yoon, Hyung-Ju,Lee, Saseong,Jang, Won Seuk,Jung, Byungjo,Kim, Wan-Uk SPIE - International Society for Optical Engineeri 2014 JOURNAL OF BIOMEDICAL OPTICS Vol.19 No.10
<P>Given the several difficulties associated with histology, including difficulty in continuous monitoring, this study aimed to investigate the feasibility of optical imaging modalities?cross-polarization color (CPC) imaging, erythema index (EI) imaging, and laser speckle contrast (LSC) imaging?for continuous evaluation and monitoring of arthritis in animal models. C57BL/6 mice, used for the evaluation of arthritis, were divided into three groups: arthritic mice group (AMG), positive control mice group (PCMG), and negative control mice group (NCMG). Complete Freunds adjuvant, mineral oil, and saline were injected into the footpad for AMG, PCMG, and NCMG, respectively. LSC and CPC images were acquired from 0 through 144 h after injection for all groups. EI images were calculated from CPC images. Variations in feet area, EI, and speckle index for each mice group over time were calculated for quantitative evaluation of arthritis. Histological examinations were performed, and the results were found to be consistent with those from optical imaging analysis. Thus, optical imaging modalities may be successfully applied for continuous evaluation and monitoring of arthritis in animal models.</P>
Size Effect in Sintering of Micro Metal Injection Molded Part
Jang, Jin Man,Lee, Won Sik,Lee, Hyong Jae,Kim, Yong In,Ko, Se Hyun,Son, Seong Ho,Park, Sung Cheol Trans Tech Publications, Ltd. 2013 Advanced materials research Vol.753 No.-
<P>Micro gears with different dimension were fabricated by micro metal injection molding and sintering behavior of the micro gear was investigated. For this, ultraprecision micro molds were prepared by micro electroforming. The sintered micro gears had outer diameter of 470μm and 250 μm, respectively. From the sintering results at 1200°C and 1250°C, the grain growth and the degree of thermal etching depend dominantly on the size of micro part rather than micro feature size. The sintering temperature of micro parts should be lower than that of macro components.</P>
An Area-Efficient, Low-VDD, Highly Reliable Multi-Cell Antifuse System Fully Operative in DRAMs
SON, Jong-Pil,KIM, Jin Ho,AHN, Woo Song,HAN, Seung Uk,YAMADA, Satoru,MOON, Byung-Sick,PARK, Churoo,HWANG, Hong-Sun,JANG, Seong-Jin,CHOI, Joo Sun,JUN, Young-Hyun,KIM, Soo-Won The Institute of Electronics, Information and Comm 2011 IEICE transactions on electronics Vol. No.
<P>A reliable antifuse scheme has been very hard to build, which has precluded its implementation in DRAM products. We devised a very reliable multi-cell structure to cope with the large process variation in the DRAM-cell-capacitor type antifuse system. The programming current did not rise above 564µA even in the nine-cell case. The cumulative distribution of the successful rupture in the multi-cell structure could be curtailed dramatically to less than 15% of the single-cell's case and the recovery problem of programmed cells after the thermal stress (300°C) had disappeared. In addition, we also presented a Post-Package Repair (PPR) scheme that could be directly coupled to the external high-voltage power rail via an additional pin with small protection circuits, saving the chip area otherwise consumed by the internal pump circuitry. A 1Gbit DDR SDRAM was fabricated using Samsung's advanced 50nm DRAM technology, successfully proving the feasibility of the proposed antifuse system implemented in it.</P>
Son, Dae-Yong,Lee, Chang-Ryul,Shin, Hee-Won,Jang, In-Hyuk,Jung, Hyun Suk,Ahn, Tae Kyu,Park, Nam-Gyu The Royal Society of Chemistry 2015 Physical chemistry chemical physics Vol.17 No.23
<P>To understand the role of the dye/oxide interface, a model system using a nanocrystalline SnO<SUB>2</SUB> and 3-hexyl thiophene based MK-2 dye is proposed. A thin interfacial TiO<SUB>2</SUB> blocking layer (IBL) is introduced in between SnO<SUB>2</SUB> and MK-2 and its effects on photocurrent–voltage, electron transport-recombination, and density of states (DOS) are systematically investigated. Compared to the bare SnO<SUB>2</SUB> film, the insertion of IBL leads to a 14-fold improvement in the power conversion efficiency (PCE) despite little change in the dye adsorption amount, which is due to the 7-fold and 2-fold increase in the photocurrent density and voltage, respectively. The charge collection efficiency is substantially improved from 38% to 96% mainly due to the increase in the electron lifetime. The IBL is also found to enhance the dye regeneration efficiency as confirmed by the 15-fold faster dye bleaching recovery dynamics. The recombination resistance increases and the DOS decreases after surface modification of SnO<SUB>2</SUB>, which is responsible for the doubly increased voltage. This study suggests that the interfacial layer between the oxide and the dye plays a crucial role in retarding recombination, improving charge collection efficiency, increasing diffusion length, accelerating dye regeneration and narrowing the density of states.</P> <P>Graphic Abstract</P><P>The interfacial blocking layer between dye and oxide was found to play crucial roles in retarding recombination, increasing diffusion, accelerating dye regeneration and narrowing the density of states. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c5cp01816a'> </P>
Son, Ho Sung,Shin, Yeon Myung,Park, Kwang Kuk,Seo, Kyung Won,Yoon, Ki Young,Jang, Hee Kyung,Lee, Sang-Ho,Yang, Song I,Kim, Jeong Hoon The Korean Gastric Cancer Association 2014 Journal of gastric cancer Vol.14 No.3
Purpose: At present, a human epidermal growth factor receptor 2 (HER2)-based concept of tumor biology has been established, and trastuzumab ($Herceptin^{(R)}$; Genentech/Roche, San Francisco, CA, USA), a monoclonal humanized antibody directed against HER2, is a pivotal agent for the management of HER2 positive (HER2+) metastatic breast cancer. It is also known that HER2 has a predictive value in gastric cancer; however, its association with the prognosis of this disease remains uncertain. The purpose of this study was to evaluate both the relationship between HER2 overexpression in the tumors of gastric cancer patients, and the prognosis of these patients who have had curative resection. Materials and Methods: A total of 139 consecutive patients with gastric cancer who underwent surgery at the Kosin University Gospel Hospital between October 2011 and March 2012 were included in this retrospective study. All tumor samples were examined for HER2 expression by immunohistochemistry. A retrospective review of the medical records was conducted to determine the correlation between the presence of HER2 overexpression and clinicopathological factors. Results: The HER2+ rate was 15.1%. HER2 overexpression was associated with histological grade (P=0.044) and Lauren classification (P=0.036). There was no significant difference in the 2-year overall survival between HER2+ and HER2- patients (P=0.396). Multivariate analysis showed that HER2 was not an independent prognostic factor. Conclusions: HER2 overexpression in tumors was associated with histological grade and Lauren classification in gastric cancer patients with curative resection. However, HER2 was not an independent prognostic factor for gastric cancer in our study.
Phenol biosensor based on hydrogel microarrays entrapping tyrosinase and quantum dots
Jang, Eunji,Son, Kyung Jin,Kim, Bumsang,Koh, Won-Gun Royal Society of Chemistry 2010 The Analyst Vol.135 No.11
<P>This paper describes the use of microarray-based biosensor system for the determination of phenol. Microarrays based on poly(ethylene glycol)(PEG) hydrogel were prepared by photopatterning of a solution containing PEG diacrylate (PEG-DA), photoinitiator, tyrosinase, and CdSe/ZnS quantum dots (QDs). During photo-induced crosslinking, tyrosinase and QDs were entrapped within the hydrogel microarrays, making the hydrogel microarray fluorescent and responsive to phenol. The entrapped tyrosinase could carry out enzyme-catalyzed oxidation of phenol to produce quinones, which subsequently quenched the fluorescence of QDs within hydrogel microarray. The fluorescence intensity of the hydrogel microarrays decreased linearly according to phenol concentration and the detection limit of this system was found to be 1.0 μM. The microarray system presented in this study could be combined with a microfluidic device as an initial step to create a phenol-detecting “micro-total-analysis-system (μ-TAS)”.</P> <P>Graphic Abstract</P><P>Detection of phenol using PEG hydrogel microarrays entrapping quantum dots (QDs) and tyrosinase based on the mechanism that QD fluorescence intensity is quenched by quinone intermediates produced from the tyrosinase-catalyzed oxidation of phenolic compounds. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0an00353k'> </P>