0346 Occupational Exposure to Lead and Cancer in Two Cohort Studies of Men and Women in Shanghai, China

Liao, Linda M,Friesen, Melissa C,Xiang, Yong-Bing,Cai, Hui,Koh, Dong-Hee,Ji, Bu-Tian,Yang, Gong,Li, Hong-Lan,Locke, Sarah J,Rothman, Nathaniel,Zheng, Wei,Gao, Yu-Tang,Shu, Xiao-Ou,Purdue, Mark P BMJ Publishing Group Ltd 2014 Occupational and environmental medicine Vol.71 No.suppl1

<P><B>Objectives</B></P><P>Epidemiologic studies of occupational lead exposure have suggested increased risks of cancers of the brain, kidney, lung, meninges, and stomach; however, the totality of the evidence is inconsistent. To clarify whether lead is a carcinogen, we investigated the relationship between occupational lead exposure and risks of these five cancer sites in two prospective cohort studies in Shanghai, China.</P><P><B>Method</B></P><P>Annual job/industry-specific estimates of lead fume and lead dust exposure were derived from a statistical model that combined expert ratings of lead intensity with inspection measurements collected by the Shanghai Centre for Disease Control and Prevention. The job/industry estimates were applied to the lifetime work histories of subjects from the Shanghai Women’s Health Study (73 363 participants) and the Shanghai Men’s Health Study (61 379 participants) to estimate cumulative exposure to lead dust and lead fume. Cohort-specific relative hazard rate ratios (RRs) and 95% confidence intervals (CI) were estimated using Cox proportional hazards regression models and then pooled using a random effects meta-analysis model.</P><P><B>Results</B></P><P>We observed a statistically significant increased risk of meningioma among individuals with estimated occupational exposure to lead dust or fumes (RR=2.4, 95% CI:1.1–5.0), and in particular among those with an above-median cumulative exposure to dust or fumes (RR=3.1, 95% CI:1.3–7.4). We observed suggestive associations with lead exposure for cancers of the kidney (RR=1.4, 95% CI:0.9–2.3) and brain (RR=1.8, 95% CI:0.7–4.8), and null findings for cancers of the lung and stomach.</P><P><B>Conclusions</B></P><P>Our findings provide additional evidence that occupational lead exposure increases risk of meningioma.</P>

Logarithmic singularities and quantum oscillations in magnetically doped topological insulators

Nandi, D.,Sodemann, Inti,Shain, K.,Lee, G. H.,Huang, K.-F.,Chang, Cui-Zu,Ou, Yunbo,Lee, S. P.,Ward, J.,Moodera, J. S.,Kim, P.,Yacoby, A. American Physical Society 2018 Physical Review B Vol.97 No.8

<P>We report magnetotransport measurements on magnetically doped (Bi, Sb)(2)Te-3 films grown by molecular beam epitaxy. In Hall bar devices, we observe logarithmic dependence of transport coefficients in temperature and bias voltage which can be understood to arise from electron-electron interaction corrections to the conductivity and self-heating. Submicron scale devices exhibit intriguing quantum oscillations at high magnetic fields with dependence on bias voltage. The observed quantum oscillations can be attributed to bulk and surface transport.</P>

Design and implementation of AMD system for response control in tall buildings

J. Teng,H.B. Xing,Y.Q. Xiao,C.Y. Liu,H. Li,J.P. Ou 국제구조공학회 2014 Smart Structures and Systems, An International Jou Vol.13 No.2

This paper mainly introduces recently developed technologies pertaining to the design and implementation of Active Mass Damper (AMD) control system on a high-rise building subjected to wind load. Discussions include introduction of real structure and the control system, the establishment of analytical model, the design and optimization of a variety of controllers, the design of time-varying variable gain feedback control strategy for limiting auxiliary mass stroke, and the design and optimization of AMD control devices. The results presented in this paper demonstrate that the proposed AMD control systems can resolve the issues pertaining to insufficient floor stiffness of the building. The control system operates well and has a good sensitivity.

Design and implementation of AMD system for response control in tall buildings

Teng, J.,Xing, H.B.,Xiao, Y.Q.,Liu, C.Y.,Li, H.,Ou, J.P. Techno-Press 2014 Smart Structures and Systems, An International Jou Vol.13 No.2

This paper mainly introduces recently developed technologies pertaining to the design and implementation of Active Mass Damper (AMD) control system on a high-rise building subjected to wind load. Discussions include introduction of real structure and the control system, the establishment of analytical model, the design and optimization of a variety of controllers, the design of time-varying variable gain feedback control strategy for limiting auxiliary mass stroke, and the design and optimization of AMD control devices. The results presented in this paper demonstrate that the proposed AMD control systems can resolve the issues pertaining to insufficient floor stiffness of the building. The control system operates well and has a good sensitivity.

Detailed Analysis of Patients with Metastasis to the Prostatic Anterior Fat Pad Lymph Nodes: A Multi-Institutional Study

Kim, I.Y.,Modi, P.K.,Sadimin, E.,Ha, Y.S.,Kim, J.H.,Skarecky, D.,Cha, D.Y.,Wambi, C.O.,Ou, Y.C.,Yuh, B.,Park, S.,Llukani, E.,Albala, D.M.,Wilson, T.,Ahlering, T.,Badani, K.,Ahn, H.,Lee, D.I.,May, M.,K Williams and Wilkins Co 2013 The Journal of urology Vol.190 No.2

Purpose: Lymph nodes in the prostatic anterior fat pad rarely harbor metastatic disease. Therefore, the characteristics of patients with prostatic anterior fat pad lymph node metastasis are not well described in the literature. We identified the perioperative characteristics and assessed the clinical outcomes of patients with prostatic anterior fat pad lymph node metastasis. Materials and Methods: At 8 tertiary care centers a total of 4,261 patients underwent complete removal and pathological analysis of the prostatic anterior fat pad. We describe preoperative and pathological characteristics, and clinical management and outcomes in patients with metastatic disease to the prostatic anterior fat pad. Results: Metastatic disease to the prostatic anterior fat pad lymph nodes was detected in 40 patients (0.94%), of whom 37 (92.5%) had intermediate or high risk features preoperatively. Most patients with prostatic anterior fat pad metastases underwent concomitant pelvic lymph node dissection, and adjuvant therapy with radiation, androgen ablation and/or chemotherapy. A total of 27 patients (67.5%) with prostatic anterior fat pad metastatic disease were up-staged as a result of prostatic anterior fat pad pathological analysis, of whom 14 (51.8%) remained free of biochemical recurrence with observation and/or definitive adjuvant/salvage therapy. Conclusions: Most patients with prostatic anterior fat pad metastatic disease had intermediate to high risk features preoperatively. In some patients with such lymph node metastasis removing these lymph nodes resulted in prolonged biochemical recurrence-free survival. Therefore, we recommend that the prostatic anterior fat pad be removed in all patients undergoing radical prostatectomy. However, pathological analysis of the prostatic anterior fat pad may be limited to patients with intermediate to high risk oncological features preoperatively.

Gasochromic Performance of WO3-nanorod Thin Films Fabricated with an ArF Excimer Laser

M. H. Yaacob,J. Z. Ou,W. Wlodarski,C. S. Kim,이정용,김영환,C. M. Oh,K. P. Dhakal,김정용,강준희 한국물리학회 2012 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.60 No.3

Thin films with tungsten trioxide (WO3) nanorods were fabricated by using an ArF pulsed laser deposition system. Because the ArF excimer laser operates at a very short wavelength of 193 nm,short enough to expect strong absorption of the photons in the semiconductor oxide targets, and because the clusters incoming to the substrates have high momentum, we could build thin films with good surface morphology. Highly homogeneous arrays of nanorods with sizes mostly in the range of 30 . 40 nm were observed. The absorbance response towards hydrogen (H2) gas was investigated for a WO3 film coated with 25-°A-thick palladium (Pd). The Pd/WO3-nanorod thin films exhibited excellent gasochromic response when measured in the visible-NIR range (400 . 1000 nm). As low as 0.06% H2 concentration was clearly sensed. A significant reversible absorbance change and fast recovery (<2 min) were observed when the films were exposed to H2 at different concentrations.

Sensor placement selection of SHM using tolerance domain and second order eigenvalue sensitivity

He, L.,Zhang, C.W.,Ou, J.P. Techno-Press 2006 Smart Structures and Systems, An International Jou Vol.2 No.2

Monitoring large-scale civil engineering structures such as offshore platforms and high-large buildings requires a large number of sensors of different types. Innovative sensor data information technologies are very extremely important for data transmission, storage and retrieval of large volume sensor data generated from large sensor networks. How to obtain the optimal sensor set and placement is more and more concerned by researchers in vibration-based SHM. In this paper, a method of determining the sensor location which aims to extract the dynamic parameter effectively is presented. The method selects the number and place of sensor being installed on or in structure by through the tolerance domain statistical inference algorithm combined with second order sensitivity technology. The method proposal first finds and determines the sub-set sensors from the theoretic measure point derived from analytical model by the statistical tolerance domain procedure under the principle of modal effective independence. The second step is to judge whether the sorted out measured point set has sensitive to the dynamic change of structure by utilizing second order characteristic value sensitivity analysis. A 76-high-building benchmark mode and an offshore platform structure sensor optimal selection are demonstrated and result shows that the method is available and feasible.

Sensor placement selection of SHM using tolerance domain and second order eigenvalue sensitivity

L. He,C.W. Zhang,J.P. Ou 국제구조공학회 2006 Smart Structures and Systems, An International Jou Vol.2 No.2

Monitoring large-scale civil engineering structures such as offshore platforms and high-large buildings requires a large number of sensors of different types. Innovative sensor data information technologies are very extremely important for data transmission, storage and retrieval of large volume sensor data generated from large sensor networks. How to obtain the optimal sensor set and placement is more and more concerned by researchers in vibration-based SHM. In this paper, a method of determining the sensor location which aims to extract the dynamic parameter effectively is presented. The method selects the number and place of sensor being installed on or in structure by through the tolerance domain statistical inference algorithm combined with second order sensitivity technology. The method proposal first finds and determines the sub-set sensors from the theoretic measure point derived from analytical model by the statistical tolerance domain procedure under the principle of modal effective independence. The second step is to judge whether the sorted out measured point set has sensitive to the dynamic change of structure by utilizing second order characteristic value sensitivity analysis. A 76-high-building benchmark mode and an offshore platform structure sensor optimal selection are demonstrated and result shows that the method is available and feasible.