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Effect of Tilliacorine on Haematological and Biochemical Parameters
A. Roychowdhuri,J. Rajan Vedasiromoni,Malaya Gupta,S. K. Mitra,Biswapati Mukherjee,Arnab Khasnobis,Tapan Seal 한국생약학회 2000 Natural Product Sciences Vol.6 No.3
Tiliacora racemosa Colebr. belonging to the family Menispermaceae, is the biggest storehouse of diphenyl bisbenzylisoquinoline (DBBI) alkaloids. Exhaustive chemical processing of the root of T. racemosa by the application of modern separation techniques yielded a DBBI alkaloid which was identified as tiliacorine using sophisticated spectroscopic methods (UV, IR, ¹H-NMR, MS). Haematological study with tiliacorine proved that there was no abnormal haematological results in comparison with the normal values. Chronic toxicity study with tiliacorine revealed that the alkaloid is devoid of any hepatotoxic and nephrotoxic action.
Effects of Tiliacorine on Voluntary Muscle and Blood Pressure
Khasnobis, Arnab,Seal, Tapan,Vedasiromoni, J. Rajan,Gupta, Malaya,Mukherjee, Biswapati The Korean Society of Pharmacognosy 2000 Natural Product Sciences Vol.6 No.1
Tiliacora racemosa Colebr. belongs to the family Menispermaceae, the biggest storehouse of diphenylbisbenzylisoquinoline (DBBI) alkaloids. Exhaustive chemical processing of the root of T. racemosa by the application of modern separation techniques yielded a DBBI alkaloid which was identified as tiliacorine using sophisticated spectroscopic methods $(UV,\;IR,\;^1H-NMR,\;Mass)$. Tiliacorine possesses neuromuscular blocking activity. It produces a dose dependent hypotensive effect in rats and cats, and this effect is blocked by atropine.
Arnab Khasnobis,Tapan Seal,J. Rajan Vedasiromoni,Malaya Gupta,Biswapati Mukherjee 한국생약학회 1999 Natural Product Sciences Vol.5 No.3
Tliacora racemosa Colebr. belonging to the family Menispermaceae is the biggest storehouse of diphenyl bisbenzylisoquinoline (DBBI) alkaloids. Exhaustive chemical processing of the root of T. racemosa by the application of modern separation techniques yielded a DBBI alkaloid which was identified as tiliacorine using sophisticated spectroscopic methods (UV, IR, ¹H-NMR, Mass). Tiliacorine potentiated the sleeping time induced by standard hypnotics viz. chlorpromazine (CPZ), pentobarbitone (PB) and diazepam (DZ) in a dose dependent manner. Tiliacorine potentiated the analgesic action of standard analgesic agents viz., morphine and meperidine. It was also found to possess anti-convulsive activity in the strychnine induced convulsion model.
Maitra, Suparna,Seal, Tapan,Mallik, Sujit,Khasnobis, Arnab,Nandi, RP,Vedasiromoni, J. Rajan,Mukherjee, Biswapati Kyung Hee Oriental Medicine Research Center 2003 Oriental pharmacy and experimental medicine Vol.3 No.3
Stephania hernandifolia belonging to the family Menispermaceae is the biggest storehouse of diphenylbisbenzylisoquinoline (DBBI) alkaloids. Exhaustive chemical processing of the bulb of S. hernandifolia by the application of modern separation techniques yielded a DBBI alkaloid which was identified as cycleanine using spectroscopic methods (UV, IR, $^1HNMR$. $^{13}CNMR$, Mass). Cycleanine showed significant anti-inflammatory activity against carrageenin induced paw oedema, comparable to that produced by diclofenac sodium, used as standard drug. It exhibited potent analgesic effects against chemical and thermal noxious stimuli. It was also found to possess anticonvulsive activity in the strychnine induced convulsion model.