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채재우(J. O. Chae),이상만(S. M. Lee),전영남(Y. N. Chun),김규정(K. J. Kim),정영식(Y. S. Jeong) 한국자동차공학회 1993 한국 자동차공학회논문집 Vol.1 No.1
Performance simulation for a Spark Ignition Wankel rotary Engine is presented in this paper. The volume of chamber at each eccentric shaft angle is evaluated by using geometric models of housing and rotor. A thermodynamic model which includes the first law of thermodynamics. combustion and convective heat transfer from chamber co~tents to surroundings is employed. A thermochemical equilib-rium model which considers 10 species(CO, CO₂, O₂, H₂, H₂O, OH, H, O NO, N₂) in the burned gas region, is also employed. Four processes of gas exchage, compression. combustion and expansion are<br/> considered and the pressure, temperature and composition of chari1ber gas at each eccentric shaft angle in each process are computed in this performance simulation. <br/> This performance simulation must be useful for optimal design of Spark Ignition Wankel Rotray Engine with parametric study for various design parameters and operating conditions.<br/>
Consequences of electronic excitations in CoFe<sub>1.90</sub>Dy<sub>0.10</sub>O<sub>4</sub>
Kumar, H.,Singh, J.P.,Srivastava, R.C.,Negi, P.,Agrawal, H.M.,Asokan, K.,Won, S.O.,Chae, K.H. Elsevier 2015 CURRENT APPLIED PHYSICS Vol.15 No.12
Present work reports the irradiation induced effects in Dy<SUP>3+</SUP> doped cobalt ferrite nanoparticles in the regime of dominant electronic excitation processes induced by 100 MeV O<SUP>7+</SUP> ion irradiation. Irradiation leads to the deterioration of crystalline phase as envisaged by X-ray diffraction. Crystallite size decreases with the increase of irradiation fluence. Disappearance of certain bands in Raman spectra at higher fluence of irradiation confirms the crystalline disorder induced by electronic excitations. Fourier transform infrared spectra show onset of cation migration from tetrahedral site to octahedral site and vice versa. X-ray absorption fine structure measurements depict the preservation of valence state of metal ions after irradiation. These measurements further infer bond breaking process in irradiated materials. Magnetic measurements carried out on these materials indicate slight increase of saturation magnetization at room temperature followed by the decrease of coercive field. Obtained results are discussed on the basis of appropriate mechanism.
정영식(Y. S. Jeong),이상만(S. M. Lee),채재우(J. O. Chae) 한국자동차공학회 1997 한국 자동차공학회논문집 Vol.5 No.4
The re quest to develop the engines that are able to run without air or with very little oxygen condition is raised with the interest of ocean science or the mines. This research had already be gun before the world war Ⅱ, but had been stagnant owing to the appearance of nuclear power. Recycle diesel engines have ability to run under the above -mentioned condition. the recycle diesel engine recirculates exhaust gases into intake port and consumes additional oxygen supplied by oxygen tanle Carbon dioxide is controlled by the absorber. The combustion and emission characteristics of recycle diesel engines are quite different with conventional one because the working fluids of recycle diesel engines consist of Ar, CO₂ and O₂ as well as N₂.<br/> Recycle diesel engine is therefore different with general diesel engine from the viewpoint of intake air composition. It is required to investigate the effect of intake composition on the combustion and emission to know recycle diesel engine. In this study, NOx concentration, smoke and cylinder pressure are measured with the variation of Ar and CO₂ Reduces show that the addition of Ar reduces NOx but increases smoke. Otherwise CO₂ reduces smoke and NOx simultaneously. Only CO₂ increases the ignition delay and both gases increase fuel consumption Ar addition is superior to CO₂addition for the performance of recycle diesel engine system but CO₂has the avantage with respect to emission.<br/>
Chae, J. w.,Teo, Y. L.,Ho, H. K.,Lee, J.,Back, H. m.,Yun, H. y.,Karlsson, M. O.,Kwon, K. i.,Chan, A. Springer Science + Business Media 2016 Cancer chemotherapy and pharmacology Vol.78 No.3
<P>An attenuated dosing (AD) sunitinib regimen of 37.5 mg daily has been suggested to reduce the toxicity reported with the standard dosing regimen to metastatic renal cell carcinoma (mRCC) patients. The aim of this study was to characterize the population pharmacokinetic (PK) properties of sunitinib and SU12662, the active metabolite, in patients receiving the AD regimen and to ascertain significant covariates influencing PK parameters. Thirty-one mRCC patients receiving AD sunitinib regimen were included. Plasma samples were collected on day 29 of each treatment cycle after the start of the therapy. Nonlinear mixed-effects modeling was applied to estimate the population PK properties of sunitinib and SU12662 as well as the effect of covariates on PK parameters. Monte Carlo simulation was also performed to predict the total trough level (TTL) of sunitinib and SU12662. Sunitinib population means for CL/F and V (d) /F (central) were 13.8 L/h and 1720 L, respectively. SU12662 population means for CL/F and V (d) /F were 42.1 L/h and 1410 L, respectively. Body surface area (BSA) and ABCB1 polymorphism significantly influenced the CL/F variability of sunitinib: CL/F (parent) = 13.8 x exp((BSA - 1.75) x 2.08 + (ABCB1 (genotype) - 0.67) x 0.61), ABCB1-0: wild genotype, 1: mutant genotype. The effect size of ABCB1 mutant genotype and BSA greater than 1.75 m(2) in relation to sunitinib clearance was 31.14 % (p = 0.006) and 22.11 % (p = 0.011), respectively, relative to the reference group. Adjusting doses of sunitinib according to BSA and ABCB1 polymorphism in Asian mRCC patients may be recommended for sufficient attainment of a target TTL of sunitinib and its metabolite.</P>