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Kim, E.,Kim, M.,Woo, D.H.,Shin, Y.,Shin, J.,Chang, N.,Oh, Y.,Kim, H.,Rheey, J.,Nakano, I.,Lee, C.,Joo, K.,Rich, Jeremy N.,Nam, D.H.,Lee, J. Cell Press 2013 Cancer cell Vol.23 No.6
Glioblastoma multiforme (GBM) displays cellular hierarchies harboring a subpopulation of stem-like cells (GSCs). Enhancer of Zeste Homolog 2 (EZH2), the lysine methyltransferase of Polycomb repressive complex 2, mediates transcriptional repression of prodifferentiation genes in both normal and neoplastic stem cells. An oncogenic role of EZH2 as a transcriptional silencer is well established; however, additional functions of EZH2 are incompletely understood. Here, we show that EZH2 binds to and methylates STAT3, leading to enhanced STAT3 activity by increased tyrosine phosphorylation of STAT3. The EZH2-STAT3 interaction preferentially occurs in GSCs relative to non-stem bulk tumor cells, and it requires a specific phosphorylation of EZH2. Inhibition of EZH2 reverses the silencing of Polycomb target genes and diminishes STAT3 activity, suggesting therapeutic strategies.
A PbS quantum-cube: conducting polymer composite for photovoltaic applications
A. A. R. Watt,P. Meredith,J. D. Riches,S. Atkinson,H. Rubinsztein-Dunlop 한국물리학회 2004 Current Applied Physics Vol.4 No.2-4
We have developed a new non-polar synthesis for lead sulde (PbS) ‘‘quantum-cubes’’ in the conjugated polymer poly-2-methoxy,5-(2-ethyl-hexyloxy-p-phenylenevinylene) MEH-PPV. The conducting polymer acts to template and control the quantum-cube growth. Transmission electron microscopy of the composites has shown a bimodal distribution of cube sizes between 5 and 15nm is produced with broad optical absorption from 300 to 650 nm. Photoluminescence suggests electronic coupling between thecubes and the conducting polymer matrix. The synthesis and initial characterization are presented in this paper.
Formation of mesostructured titania thin films using isopropoxide precursors
G.Q.M. Lu,I. Kartini,P. Meredith,Diniz da Costa,J. D. Riches 한국물리학회 2004 Current Applied Physics Vol.4 No.2-4
Mesostructured titania thin lms were prepared by an evaporation-induced self-assembly process. The highly acidic sol pre-cursors contained titanium(IV) tetraisopropoxide (TTIP) as a titanium source, a tri-block copolymer Pluronic P123 as a template,and acetylacetonate and HCl as hydrolysis inhibitors. Characteristics of the resultant titania thin lms were studied using X-raydiraction (XRD) analysis, N2-adsorption/desorption analysis, and transmission electron microscopy (TEM). XRD and TEMinvestigations on the as-synthesised lms revealed the appearance of cubic-like, pseudohexagonal, and lamellar mesophases;depending on the amount of water in the sols of lm precursors. Template removal by a calcination process yields high surface area(320360 m2/g) mesoporous materials with crystalline anatase frameworks. Water content also inuences the degree of anatasecrystallinity of the calcined lms. Higher water content resulted in improved anatase crystallinity. These nanostructured materialsare of interest for photocatalysts, photoelectrochemical solar cells and other photonic devices.