Gerontology and Assistive Technology Innovation

( Inoue Takenobu ) 한국감성과학회 2018 추계학술대회 Vol.2018 No.-

Carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone-induced toxicities in rats: comparative study with other mitochondrial uncouplers (2,4-dinitrophenol, OPC-163493 and tolcapone)

Inoue Yuki,Wada Yuko,Sato Makoto,Sato Seiji,Okamoto Takashi,Kanemoto Naohide 한국독성학회 2023 Toxicological Research Vol.39 No.4

FCCP (carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone) is known to inhibit oxidative phosphorylation as a protonophore, dissipating the proton gradient across the inner mitochondrial membrane. To understand the toxicity of FCCP, 3-day, 2- and 4-week repeated oral dose studies were performed in male rats. In the 3-day and 2-week repeated dose toxicity studies, observations included salivation, increased body temperature, and dead and moribund animals. Increased liver weight was observed in conjunction with hydropic degeneration and centrilobular necrosis of hepatocytes. In addition, pathological changes were observed in the pancreas, testis, epididymal duct, stomach and parotid gland. Electron microscopic examination revealed mitochondrial pleomorphism in the hepatocytes. Swelling of mitochondria was observed in the alpha cells and beta cells of the pancreas. Dilatation of rough endoplasmic reticulum, Golgi bodies and loss of secretory granules were also noted in the beta cells of the pancreas. FCCP was also compared with three other mUncouplers (DNP, OPC-163493 and tolcapone) with regard to in vitro mitochondrial uncoupling (mUncoupling) activities. FCCP produced the peak ΔOCR (oxygen consumption rate) at the lowest concentration (0.4 μM), followed by OPC-163493, tolcapone, and DNP, based on peak values in ascending order of concentration (2.5, 10, and 50 μM, respectively). Considering the relationship between the mUncoupling activity and toxicity profile of the four mUncouplers, there is no parallel relationship between the in vitro mUncoupling activity and the degree of in vivo toxicity. These findings may contribute to the efficient development of new mitochondrial uncoupler candidates.

Status Aspirations and Gender Awareness of Women Undergraduates in Guam

Inoue, Yukiko Ewha Womans University Press 1999 Asian Journal of Women's Studies(AJWS) Vol.5 No.4

This study examines the status aspirations of undergraduate women in Guam; their awareness of gender equality in employment, and how these affect their academic and social aspirations. A random sample of 350 students, which represented the culturally diverse setting of the study, was thus selected from the degree and non-degree programs of the Arts and Science faculties of the University of Guam (UOG). A questionnaire was administered to the sample and had a response rate of 32 percent. The respondents revealed a strong desire for pursuing careers, earning for themselves, and they did not perceive gender discrimination as a significant impediment in employment. Furthermore, no differences in attitudes and perceptions were identified between the two major ethnic groups-Chamorro and non-Chamorro. This may be due to the manner in which Guam has evolved and the kind of interaction students of the UOG have among themselves on campus. Implications of the study are discussed and some questions for future research are posed.

International Expansion Strategy in the Direct Marketing Company

INOUE, Yoshimi(井上 善美) 한국유통학회 2016 한국유통학회 학술대회 발표논문집 Vol.2016 No.10

박각시과의 1신아종, Ambulyx japanica koreana(나비목) 기재

Inoue, Hiroshi 한국응용곤충학회 1993 Insecta Koreana Vol.10 No.1

남, 북한 각 지역으로 부터 채집된 재료를 대상으로 비교검토한 결과 박각시과의 1신아종 Ambulyx japonica koreana subsp. nov.을 기재발표한다. A new subspecies: Ambulyx japonica koreana is described from noth and South Korea.

NONLINEAR FORCE-FREE MODELING OF A THREE-DIMENSIONAL SIGMOID OBSERVED ON THE SUN

Inoue, S.,Magara, T.,Watari, S.,Choe, G. S. IOP Publishing 2012 The Astrophysical journal Vol.747 No.1

<P>In this work, we analyze the characteristics of the three-dimensional magnetic structure of a sigmoid observed over an active region (AR 10930) and followed by X-class flares. This is accomplished by combining a nonlinear force-free field (NLFFF) model of a coronal magnetic field and the high-resolution vector-field measurement of a photospheric magnetic field by Hinode. The key findings of our analysis reveal that the value of the X-ray intensity associated with the sigmoid is more sensitive to the strength of the electric current rather than the twist of the field lines. The strong electric current flows along the magnetic field lines and composes the central part of the sigmoid, even though the twist of the field lines is weak in that region. On the other hand, the outer region (i.e., the elbow part) of the sigmoid is basically occupied by field lines of strong twist and weak current density. Consequently, weak X-ray emission is observed. As the initial Ca II illumination basically occurs from the central part of the sigmoid, this region plays an important role in determining the onset mechanism of the flare despite its weak twisted field-line configuration. We also compare our results with the magnetohydrodynamic simulation for the formation of a sigmoid. Although the estimated values of the twist from the simulation are found to be a little higher than the values obtained from the NLFFF, we find that the field-line configurations generated by the simulation and NLFFF are remarkably analogous as long as we deal with the lower coronal region.</P>

TWIST AND CONNECTIVITY OF MAGNETIC FIELD LINES IN THE SOLAR ACTIVE REGION NOAA 10930

Inoue, S.,Kusano, K.,Magara, T.,Shiota, D.,Yamamoto, T. T. IOP Publishing 2011 The Astrophysical journal Vol.738 No.2

<P>Twist and connectivity of magnetic field lines in the flare-productive active region NOAA 10930 are investigated in terms of the vector magnetograms observed by the Solar Optical Telescope on board the Hinode satellite and the nonlinear force-free field (NLFFF) extrapolation. First, we show that the footpoints of magnetic field lines reconstructed by the NLFFF correspond well to the conjugate pair of highly sheared flare ribbons on the Ca II images, which were observed by Hinode as an X3.4 class flare on 2006 December 13. This demonstrates that the NLFFF extrapolation may be used to analyze the magnetic field connectivity. Second, we find that the twist of magnetic field lines anchored on the flare ribbons increased as the ribbons moved away from the magnetic polarity inversion line in the early phase of the flare. This suggests that magnetic reconnection might commence from a region located below the most strongly twisted field. Third, we reveal that the magnetic flux twisted more than a half turn and gradually increased during the last one day prior to the onset of the flare, and that it quickly decreased for two hours after the flare. This is consistent with the store-and-release scenario of magnetic helicity. However, within this active region, only a small fraction of the flux was twisted by more than one full turn and the field lines that reconnected first were twisted less than one turn. These results imply that the kink mode instability could hardly occur, at least before the onset of flare. Based on our results, we discuss the trigger process of solar flares.</P>

FATE OF TRICRESYL PHOSPHATE ISOMERS IN KUROSE RIVER(JAPAN)

INOUE,Yujirou,TAKIMOTO,Kazuto,OKADA,Mitsumasa,CHO,Kyung Jin 嶺南大學校 環境問題硏究所 1994 環境硏究 Vol.14 No.1

Origin and fate of TCP isomers were studied in Kurose River, Hiroshima, Japan. As main factors to control the fate, the adsorption characteristics of TCP isomers onto sediment and biodegradation in river water and sediment were studied. Concentration of TCP isomers in river water, sediment and SS were the highest in autumn. It was about ten times as large as that in winter. High concentration of o-TCP was noted except for spring. Different from other seasons, the concentrations of o-TCP was relatively low and m-TCP was not detected in summer. These variation seemed to be due to the difference in the rate of biodegradation with temperature. The concentrations of TCP isomers increased with the increase in flow rate under flooding condition. TCP in the river originated from non-point sources and not from wastewaters nor equilibrium was observed between bottom sediment and river water indicating TCP was biodegraded rapidly in the bottom sediment. The biodegradation rate in the sediment was the lowest for o-TCP and the highest for p-TCP. The biodegradation rate of m-TCP was small under low temperature, whereas it was large in high temperature above 20℃. The most biodegradable isomer, p-TCP, was not detected in most cases.

박각시과의 1신아종, Ambulyx japanica koreana(나비목) 기재

Inoue, Hiroshi 한국응용곤충학회 1993 INSECTA KOREANA Vol.10 No.-

남, 북한 각 지역으로 부터 채집된 재료를 대상으로 비교검토한 결과 박각시과의 1신아종 Ambulyx japonica koreana subsp. nov.을 기재발표한다. A new subspecies: Ambulyx japonica koreana is described from noth and South Korea.

New Aluminum-Based Amorphous Alloys with High Strength and Good Ductility

Inoue,Akihisa,Masumoto,Tsuyoshi 대한금속재료학회(대한금속학회) 1988 대한금속·재료학회지 Vol.26 No.8

New Al-based amorphous alloys with high strength, good ductility and high corrosion resistance have been produced by liquid quenching in Al-Y-Ni and Al-La-Ni systems. The tensile fracture strength (σ_f) and Vickers hardness reach 1140 MPa and 300 DPN for Al_(87)Y_8Ni_5 and 1080 Mpa and 260 DPN for Al_(87)La_8Ni_5. The specific strengths, defined by the ratio of σ₁to density, are as high as 34 to 38, which is much higher than those for conventional alloy steels, Al-based alloys, and Ti-based alloys. These new Al-base amorphous alloys are effected to be used in many applications as a new type of high-strength material with low density and high corrosion resistance.