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ROR@? Attenuates Wnt/sz-Catenin Signaling by PKC@?-Dependent Phosphorylation in Colon Cancer
Lee, J.M.,Kim, I.S.,Kim, H.,Lee, J.S.,Kim, K.,Yim, H.Y.,Jeong, J.,Kim, J.H.,Kim, J.Y.,Lee, H.,Seo, S.B.,Kim, H.,Rosenfeld, M.G.,Kim, K.I.,Baek, S.H. Cell Press 2010 Molecular cell Vol.37 No.2
<P>Wnt family members play diverse roles in development and disease. Noncanonical Wnt ligands can inhibit canonical Wnt signaling depending on the cellular context; however, the underlying mechanism of this antagonism remains poorly understood. Here we identify a specific mechanism of orphan nuclear receptor ROR alpha-mediated inhibition of canonical Wnt signaling in colon cancer. Wnt5a/PKC alpha-dependent phosphorylation on serine residue 35 of ROR alpha is crucial to link ROR alpha to Wnt/beta-catenin signaling, which exerts inhibitory function of the expression of Wnt/beta-catenin target genes. Intriguingly, there is a significant correlation of reduction of ROR alpha phosphorylation in colorectal tumor cases compared to their normal counterpart, providing the clinical relevance of the findings. Our data provide evidence for a role of ROR alpha, functioning at the crossroads between the canonical and the noncanonical Wnt signaling pathways, in mediating transrepression of the Wnt/beta-catenin target genes, thereby providing new approaches for the development of therapeutic agents for human cancers.</P>
Effects of magnetic anisotropy and exchange in Tm2Fe17
Pirogov, A. N.,Bogdanov, S. G.,Rosenfeld, E. V.,Park, J. -G.,Choi, Y. N.,Lee, Seongsu,Prokeš,, K.,Golosova, N. O.,Sashin, I. L.,Kudrevatykh, N. V.,Skryabin, Yu. N.,Vokhmyanin, A. P. Pleiades Publishing 2012 Journal of experimental and theoretical physics Vol.115 No.5