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Comparison of Methods for Determining ABO Blood Type in Cynomolgus Macaques (Macaca fascicularis)
Kim, Tae M.,Park, Hyojun,Cho, Kahee,Kim, Jong S.,Park, Mi K.,Choi, Ju Y.,Park, Jae B.,Park, Wan J.,Kim, Sung J. AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE 2015 Journal of the American Association for Laboratory Vol.54 No.3
A self-healing Sn anode with an ultra-long cycle life for sodium-ion batteries
Kim, Changhyeon,Kim, Icpyo,Kim, Huihun,Sadan, Milan K.,Yeo, Hyewon,Cho, Gyubong,Ahn, Jaepyoung,Ahn, Jouhyeon,Ahn, Hyojun The Royal Society of Chemistry 2018 Journal of Materials Chemistry A Vol.6 No.45
<P>For a next-generation sodium battery to replace lithium ion batteries, it is essential to develop an anode with a long cycle life and high rate. Sn is considered to be an ideal candidate for the anode of sodium ion batteries. Here, we report a Sn anode that exhibits ultra-long-term cycle stability with a high capacity of 554 mA h g<SUP>−1</SUP> at 10C-rate for 5000 cycles. The optimized cell configuration consists of 1,2-dimethoxyethane as the electrolyte, a double separator including a nanoporous membrane, and a Sn anode with MWCNT as a conductive additive. Its capacity retention reaches up to 99.8% and its coulombic efficiency is near 100% for 5000 cycles. Surprisingly, we have discovered that the Sn powder exhibits a self-healing phenomenon during cycling. Sn is initially pulverized into a nanometer-sized powder, and then forms a three-dimensional porous coral-like structure in which ligament-shaped micrometer-sized Sn particles are connected with a low coordination number by room temperature sintering. The coral-like structure is mechanically stable towards volume change and electrically connected. The self-healing structure and mechanism provide a direction for the design of other electrodes with alloying mechanisms.</P>
Hyojune Kim,Si-Jung Song,In-Ho Jeon,Kyoung Hwan Koh 대한견주관절학회 2022 대한견주관절의학회지 Vol.25 No.1
Background: The treatment approach for proximal humeral fractures is determined by various factors, including patient age, sex, dominant arm, fracture pattern, presence of osteoporosis, preexisting arthritis, rotator cuff status, and medical comorbidities. However, there is a lack of consensus in the literature regarding the optimal treatment for displaced proximal humeral fractures. This study aimed to assess and quantify the decision-making process for either conservative or surgical treatment and the choice of surgical method among shoulder surgeons when treating proximal humeral fractures. Methods: Forty sets of true anteroposterior view, scapular Y projection view, and three-dimensional computed tomograms of proximal humeral fractures were provided to 12 shoulder surgeons along with clinical information. Surveys regarding Neer classification, decisions between conservative and surgical treatments, and chosen methods were conducted twice with an interval of 2 months. The factors affecting the treatment plans were also assessed. Results: The inter-rater agreement was fair for Neer classification (kappa=0.395), moderate for the decision between conservative and surgical treatments (kappa=0.528), and substantial for the chosen method of surgical treatment (kappa=0.740). The percentage of agreement was 71.1% for Neer classification, 84.6% for the decision between conservative and surgical treatment, and 96.4% for the chosen method of surgical treatment. The fracture pattern was the most crucial factor in deciding between conservative and surgical treatments, followed by age and physical activity. Conclusions: The decision between conservative and surgical treatment for proximal humeral fractures showed good agreement, while the chosen method between osteosynthesis and arthroplasty showed substantial agreement among shoulder surgeons.
Postoperative Rehabilitation of Elbow Pain
Hyojune Kim,Kyoung Hwan Koh,In-Ho Jeon Ewha Womans University School of Medicine 2023 EMJ (Ewha medical journal) Vol.46 No.4
The elbow joint, with its intricate anatomy, plays a pivotal role in the upper limb's functional movements. Common surgical indications include epicondylitis, osteoarthritis, tendon tears, and neuropathies. Irrespective of the nature of surgery, appropriate postoperative rehabilitation is essential to enhance recovery, optimize functional outcomes, and minimize complications. Protective measures for the elbow vary based on the surgical procedure is performed. Extended postoperative immobilization is generally not advised. Temporary splints may be utilized to protect the soft tissues in the immediate aftermath of surgery, with patients advised to intermittently remove them to facilitate elbow movement. To increase mobility while ensuring the safety of repaired tendons or ligaments, articulated dynamic braces are recommended. This review delivers clinically useful recommendations specific to various surgical procedures, designed to be user-friendly even for non-specialists in orthopaedic surgery.
Hyojune Kim,Euisop Lee,In-Ho Jeon,Kyoung Hwan Koh 대한견주관절의학회 2021 대한견주관절학회 학술대회논문집 Vol.2021 No.3
Introduction and Background We aimed to compare the clinical efficacy and safety of arthroscopy-guided continuous suprascapular nerve block(AS-SSNB) with ultrasound-guided continuous interscalene block (US-ISB) for patients with arthroscopic rotator cuff repair. Material and Method A prospective study was performed between March and June 2020. Totally, 75 patients were included and divided into two groups: In 38 patients of group 1 (AS-SSNB), indwelling catheter was introduced via Neviaser portal under arthroscopic view just before closing the portal at the end of the surgery. In 37 patients of group 2 (US-ISB), indwelling catheter was inserted towards the interscalene brachial plexus just prior to the surgery under US control. The primary outcome was the pain score measured by a visual analog scale (VAS) at postoperative 8 hours during admission, which was most painful in pilot study. Comparison was conducted at different times (postoperative 4, 8, 24, and 48 hours). The secondary outcome was the events of neurologic complications such as upper extremity’s sensory/motor change, hemi-diaphragmatic paralysis, dyspnea, hoarseness, and Horner syndrome. Additionally, the opioid usage until postoperative 3 weeks was evaluated between two groups. Results The VAS score of group 1 was comparable at every postoperative times and showed similar trends with group 2. (ANOVA test, p = 0.919; trends, p = 0.132). Events of complications which were related to temporally neurologic deficit were more common in group 2 (8 vs 31 patients, p < 0.001). The decreased excursion of diaphragm was more common in group 2 (partial or complete palsy of hemi-diaphragm: 1 vs 28 patients, p-value < 0.001). Drug usage of narcotics were similar in both groups (morphine milligram equivalents. per kilogram: 1.75 vs 1.55, p = 0.195). Conclusions Arthroscopy-guided SSNB showed efficiently reduced postoperative pain after arthroscopy rotator cuff repair without less neurologic complications, comparable to US-guided ISB.
Polymeric nano-shielded islets with heparin-polyethylene glycol in a non-human primate model
Park, Hyojun,Haque, Muhammad R.,Park, Jae Berm,Lee, Kyo Won,Lee, Sanghoon,Kwon, Yeongbeen,Lee, Han Sin,Kim, Geun-Soo,Shin, Du Yeon,Jin, Sang-Man,Kim, Jae Hyeon,Kang, Hee Jung,Byun, Youngro,Kim, Sung J Elsevier 2018 Biomaterials Vol.171 No.-
<P><B>Abstract</B></P> <P>Intraportal pancreatic islet transplantation incurs huge cell losses during its early stages due to instant blood-mediated inflammatory reactions (IBMIRs), which may also drive regulation of the adaptive immune system. Therefore, a method that evades IBMIR will improve clinical islet transplantation. We used a layer-by-layer approach to shield non-human primate (NHP) islets with polyethylene glycol (nano-shielded islets, NSIs) and polyethylene glycol plus heparin (heparin nano-shielded islets; HNSIs). Islets ranging from 10,000 to 20,000 IEQ/kg body weight were transplanted into 19 cynomolgus monkeys (n = 4, control; n = 5, NSI; and n = 10, HNSI). The mean C-peptide positive graft survival times were 68.5, 64 and 108 days for the control, NSI and HNSI groups, respectively (<I>P</I> = 0.012). HNSI also reduced the factors responsible for IBMIR <I>in vitro</I>. Based on these data, HNSIs in conjunction with clinically established immunosuppressive drug regimens will result in superior outcomes compared to those achieved with the current protocol for clinical islet transplantation.</P>