비외상성 두개내 출혈 환자에서 심근손상의 발생과 예후에 미치는 영향

강구현,황성호,이강현,조준휘,김성환,문중범,박해상,이서영,이성수,김헌주 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Objective: The aim of this study was to investigate the clinical significance of myocardial injuries in patients with nontraumatic intracranial hemorrhage by identifying the occurrence of myocardial injury and defining its correlation with subsequent cardiovascular events. Subjects and methods: One hundred twenty-four patients with nontraumatic intracraninal hemorrhage presented to the emergency department within six hours from onset of symptoms were enrolled. Brain CT, serial electrocardiography, and echocardiography were done at the emergency center. Blood samples for troponin I and creatine kinase(CK)-MB were drawn immediately and eight hours after admission, Troponin I and CK-MB were measured using a chemiluminescent immunoassay, respectively. Results: Electrocardiographic and echocardiography abnormalities were found in 65 cases(52.4%) and 21 cases(17%), respectively. Serum troponin I and creative kinase-MB were increased in 35 cases (28.2%) and in 58 cases(46.8%), respectively. Abnormal findings of echocardiography and ECG, as well as elevated levels of serum troponin I and creative kinase-MB, were associated with an increased risk of cardiovascular event and survival. Logistic regression analysis revealed that an abnormal echcocardiographic finding and elevation of serum troponin I were factors associated with the occurrence an adverse cardiovascular event and that electrocardiographic abnormalities and initial mental status were factors associated with poor prognosis. Conclusion: This study reveals that actual myocardial injury develops in a significant proportion of patients with nontraumatic intracranial hemorrhage and that the development of the myocardial injury is associated with an adverse cardiovascular event that occurs during admission.

산불 피해 소나무재의 역학적 특성 및 급속오븐 건조특성

황원중,권구중,박종수,김남훈 한국목재공학회 2003 목재공학 Vol.31 No.4

본 연구에서는 산불 피해 소나무재의 이용을 위한 기초자료를 얻고자 역학적 및 건조 특성을 조사하였다. 산불피해재는 종압축 특성, 전단강도, 충격휨흡수에너지 등에서 건전재와 거의 유사한 결과를 보여주었으며, 산불피해재 변재부의 휨특성은 건전재보다 양호하게 나타났다. 건전재와 산불피해재 변재부의 생재함수율은 산불피해재가 다소 낮았으나, 건조속도는 거의 차이가 없었다. 건조시 발생되는 초기할렬은 건전재가 산불피해재보다 발생율이 높았고, 내부할렬은 건전재와 산불피해재에서 발생되지 않았다. 따라서 산불에 의해 피해를 입은 목재의 대부분은 수피부를 제거하여 이용할 경우 건전재와 거의 동일한 용도로서 사용이 가능할 것으로 생각된다. The Mechanical and drying characteristics of Pinus densiflora wood, which was damaged by forest fire, and sound wood were examined. There were no significant differences in axial compressive properties, shearing strength and impact bending absorbed energy between damaged and sound woods. But the bending properties of damaged wood were slightly higher than those of sound wood. The green moisture content of sapwood in damaged wood was lower than that in sound wood, but oven-drying rate was similar in both woods. Number of initial check in damaged wood was smaller than that in sound wood, and inner check in damaged and sound woods was not observed. Consequently, it is considered that mostly damaged wood by forest fire can be used for wood material after removing the considered that mostly damaged wood by forest fire can be used for wood material after removing the bark.

국내산 잣나무와 낙엽송의 재질

권성민,황원중,권구중,김남훈 江原大學校 森林科學硏究所 2004 Journal of Forest Science Vol.20 No.-

국산 잣나무와 낙엽송의 비중, 연륜폭, 만재율, 종압축강도, 횡압축강도 및 전단강도를 측정하고 방사 ?향의 병이를 조사하여 다음의 결과를 얻었다. 1) 비중은 잣나무가 0.48로 낙엽송의 0.88보다 약 2배정도 낮은 값을 보였다. 두 수종 모두 수심에서 낮은 값을 보여주고 그 후 약 15연륜 까지 다소 증가하다가 일정해지는 경향을 보여주었다. 2) 연륜폭은 잣나무 3.43㎜, 낙엽송 2.83㎜로 잣나무가 낙엽송에 비해 넓었으며, 만재율은 잣나무 30%, 낙엽송 47%로 낙엽송이 잣나무에 비해 높았다. 두 수종 모두 만재율이 커짐에 따라 비중은 커지는 경향을 나타냈다. 3) 종압축강도와 종압축 비례한도, 종압축 영계수는 잣나무가 각각 300kgf/㎠, 270kgf/㎠, 9.2×10³kgf/㎠로서 낙엽송의 600kgf/㎠, 550kgf/㎠, 20×10³kgf/㎠에 비해 모두 낮은 수치를 나타내었다. 종압축강도, 종압축 비례한도 및 영계수의 방사방향변이는 두 수종 모두 뚜렷한 경향을 보이지 않았다. 4) 방사단면의 전단강도는 잣나무가 51kgf/㎠, 낙엽송이 69kgf/㎠으로 낙엽송이 컸으며, 접선단면은 잣나무가 56kgf/㎠, 낙엽송이 86kgf/㎠으로 낙엽송이 큰 값을 나타내었다. Density, annual ring width, latewood percentage and compressive properties of Pinus koraiensis and Larix kaempferi grown in Research Forest of Kangwon National University were measured and their radial variations were investigated. Density(Wa/Va) of Pinus koraiensis and Larix kaempferi was 0.48g/cm² and 0.88g/cm², respectively. Density of both species was slightly lower at pith area, increased gradually with cambial age up to about 15 years and then became constant. Annual ring width of both species was 3.43㎜ and 2.83㎜, respectively. Annual ring width of both species was irregular at pith area but regular after about 20 years. Latewood percentage of both species was 30% and 47%, respectively. Latewood percentage of Pinus koraiensis and Larix kaempferi increased with cambial age up to 14 years and 10 years, respectively and then became constant. Compressive strength, proportional limit and Young's modulus parallel to the grain of Pinus koraiensis were 330 kgf/cm², 270 kgf/cm² and 9.2×10³ kgf/cm², and those of Larix kaempferi were 600 kgf/cm², 550 kgf/cm² and 20×10³ kgf/cm², respectively. Shearing strength in radial direction of Pinus koraiensis and Larix kaempferi was 51 kgf/cm² and 69 kgf/cm², and that of tangential direction was 56 kgf/cm² and 86 kgf/cm², respectively. In this study, compressive and shearing properties of both species did not show any significant differences between juvenile wood and adult wood. Both species showed significant differences in the measured values.

A novel mutation in XLRS1 gene in X-linked juvenile retinoschisis

Kim, Da Hyun,Heo, Sun Hee,Seo, Go Hun,Oh, Arum,Kim, Taeho,Kim, Gu-Hwan,Yoon, Young Hee,Yoo, Han-Wook,Lee, Beom Hee Korean Society of Medical Genetics and Genomics 2018 대한의학유전학회지 Vol.15 No.1

X-linked juvenile retinoschisis (XLRS) is characterized by the progressive loss of visual acuity and vitreous hemorrhage. XLRS is caused by a mutation of retinoschisin 1 (RS1) gene at Xp22.13. In the current report, a 2-year-old Korean patient with XLRS was described. The germline deletion of exon 1 was identified in the RS1 gene. Considering X-linked inheritance pattern, validation of a carrier state of a patient's mother is important for the genetic counseling of other family members and for the future reproductive plan. To confirm the carrier state of his mother, the multiplex ligation-dependent probe amplification analysis was done using peripheral leukocytes and found the heterozygous deletion of exon 1 in his mother.

Genetic Diversity and Reassortment of Hantaan Virus Tripartite RNA Genomes in Nature, the Republic of Korea

Kim, Jeong-Ah,Kim, Won-keun,No, Jin Sun,Lee, Seung-Ho,Lee, Sook-Young,Kim, Ji Hye,Kho, Jeong Hoon,Lee, Daesang,Song, Dong Hyun,Gu, Se Hun,Jeong, Seong Tae,Park, Man-Seong,Kim, Heung-Chul,Klein, Terry Public Library of Science 2016 PLoS neglected tropical diseases Vol.10 No.6

<▼1><P><B>Background</B></P><P>Hantaan virus (HTNV), a negative sense tripartite RNA virus of the Family <I>Bunyaviridae</I>, is the most prevalent hantavirus in the Republic of Korea (ROK). It is the causative agent of Hemorrhagic Fever with Renal Syndrome (HFRS) in humans and maintained in the striped field mouse, <I>Apodemus agrarius</I>, the primary zoonotic host. Clinical HFRS cases have been reported commonly in HFRS-endemic areas of Gyeonggi province. Recently, the death of a member of the ROK military from Gangwon province due to HFRS prompted an investigation of the epidemiology and distribution of hantaviruses in Gangwon and Gyeonggi provinces that border the demilitarized zone separating North and South Korea.</P><P><B>Methodology and Principal Findings</B></P><P>To elucidate the geographic distribution and molecular diversity of HTNV, whole genome sequences of HTNV Large (L), Medium (M), and Small (S) segments were acquired from lung tissues of <I>A</I>. <I>agrarius</I> captured from 2003–2014. Consistent with the clinical incidence of HFRS established by the Korea Centers for Disease Control & Prevention (KCDC), the prevalence of HTNV in naturally infected mice in Gangwon province was lower than for Gyeonggi province. Whole genomic sequences of 34 HTNV strains were identified and a phylogenetic analysis showed geographic diversity of the virus in the limited areas. Reassortment analysis first suggested an occurrence of genetic exchange of HTNV genomes in nature, ROK.</P><P><B>Conclusion/Significance</B></P><P>This study is the first report to demonstrate the molecular prevalence of HTNV in Gangwon province. Whole genome sequencing of HTNV showed well-supported geographic lineages and the molecular diversity in the northern region of ROK due to a natural reassortment of HTNV genomes. These observations contribute to a better understanding of the genetic diversity and molecular evolution of hantaviruses. Also, the full-length of HTNV tripartite genomes will provide a database for phylogeographic analysis of spatial and temporal outbreaks of hantavirus infection.</P></▼1><▼2><P><B>Author Summary</B></P><P>Hemorrhagic Fever with Renal Syndrome (HFRS) and Hantavirus Pulmonary Syndrome (HPS) are endemic zoonotic infectious diseases caused by hantaviruses that belong to the Family <I>Bunyaviridae</I> containing negative-sense tripartite RNA genomes. Hantaviruses pose a critical emerging public health threat, with up to 200,000 clinical cases reported annually worldwide with 1–36% case fatality rates. In humans, hantavirus-borne diseases are contracted by the inhalation of viruses aerosolized from rodent excreta. However, there is no effective therapeutic or vaccine to prevent from the disease. Whole genome sequences of Hantaan virus (HTNV) were acquired from lung tissues of <I>Apodemus agrarius</I> captured in HFRS-endemic areas of the Republic of Korea (ROK). Phylogenetic analyses demonstrated that sequences of the HTNV tripartite genomes clustered geographically, showing broad diversity of HTNV throughout the areas surveyed. Reassortment analysis first suggested a natural occurrence of the HTNV genetic exchange in the ROK. These observations contribute to a better understanding of the genetic diversity and molecular evolution of hantaviruses in HFRS-endemic regions. The complete sequences of HTNV genomes will provide a database for the phylogeographic analysis and surveillance of endemic hantavirus-borne diseases.</P></▼2>

Genetic and clinical characteristics of Korean patients with neurofibromatosis type 2

Kim, Hye-ji,Seo, Go Hun,Kim, Yoon Myung,Kim, Gu-Hwan,Seo, Eul-Ju,Ra, Young-Shin,Choi, Jin-Ho,Yoo, Han-Wook,Lee, Beom Hee Korean Society of Medical Genetics and Genomics 2017 대한의학유전학회지 Vol.14 No.2

Purpose: Neurofibromatosis type 2 (NF2) is characterized by multiple tumors, including vestibular schwannoma (VS) and others affecting cranial and peripheral nerves. NF2 is caused by mutation of the NF2 gene. The mutation spectrum of NF2 has not been characterized in Korean patients. In the current study, the clinical and genetic characteristics of Korean NF2 patients were analyzed. Materials and Methods: Twenty-five unrelated Korean families were enrolled according to the Manchester criteria. Genetic analysis was performed by direct sequencing and multiplex ligation-dependent probe amplification methods using genomic DNA from peripheral lymphocytes or tumor tissues. Results: All patients had bilateral/unilateral VS and/or other cranial and peripheral nerve tumors. Two patients were familial cases and the other 24 patients were sporadic. Germline NF2 mutations were detected in peripheral lymphocytes from both familial cases, but only in 26.1% of the 23 sporadic families. Somatic mutations were also found in tumor tissues from two of the sporadic families. These somatic mutations were not found in peripheral lymphocytes. A total of 10 different mutations including 2 novel mutations were found in 40.0% of studied families. Five mutations (50.0%) were located in exon 6 of NF2, the FERM domain coding region. Conclusion: Family history was an important factor in identifying germline NF2 mutations. Further study is required to investigate whether exon 6 is a mutation hotspot in Korean NF2 patients and its correlation to phenotypic severity.

Low prevalence of argininosuccinate lyase deficiency among inherited urea cycle disorders in Korea

Kim, Dahye,Ko, Jung Min,Kim, Yoon-myung,Seo, Go Hun,Kim, Gu-Hwan,Lee, Beom Hee,Yoo, Han-Wook Nature Publishing Group 2018 Journal of human genetics Vol.63 No.8

Magnetic mesoporous materials for removal of environmental wastes

Kim, Byoung Chan,Lee, Jinwoo,Um, Wooyong,Kim, Jaeyun,Joo, Jin,Lee, Jin Hyung,Kwak, Ja Hun,Kim, Jae Hyun,Lee, Changha,Lee, Hongshin,Addleman, R. Shane,Hyeon, Taeghwan,Gu, Man Bock,Kim, Jungbae Elsevier 2011 Journal of hazardous materials Vol.192 No.3

<P><B>Highlights</B></P><P>• Iron oxide particle embedded mesoporous silica and carbon are synthesized. • Both mesoporous materials are separated easily under aqueous condition using magnet. • Mercury or fluorescein is removed by using magnetic mesoporous material. • Tyrosinase is immobilized in magnetic mesoporous silica and reused after reaction. • Magnetic mesoporous materials are applicable to removal of environmental wastes.</P> <P><B>Abstract</B></P><P>We have synthesized two different magnetic mesoporous materials that can be easily separated from aqueous solutions by applying a magnetic field. Synthesized magnetic mesoporous materials, Mag-SBA-15 (magnetic ordered mesoporous silica) and Mag-OMC (magnetic ordered mesoporous carbon), have a high loading capacity of contaminants due to high surface area of the supports and high magnetic activity due to the embedded iron oxide particles. Application of surface-modified Mag-SBA-15 was investigated for the collection of mercury from water. The mercury adsorption using Mag-SBA-15 was rapid during the initial contact time and reached a steady-state condition, with an uptake of approximately 97% after 7h. Application of Mag-OMC for collection of organics from water, using fluorescein as an easily trackable model analyte, was explored. The fluorescein was absorbed into Mag-OMC within minutes and the fluorescent intensity of solution was completely disappeared after an hour. In another application, Mag-SBA-15 was used as a host of tyrosinase, and employed as recyclable catalytic scaffolds for tyrosinase-catalyzed biodegradation of catechol. Crosslinked tyrosinase in Mag-SBA-15, prepared in a two step process of tyrosinase adsorption and crosslinking, was stable enough for catechol degradation with no serious loss of enzyme activity. Considering these results of cleaning up water from toxic inorganic and organic contaminants, magnetic mesoporous materials have a great potential to be employed for the removal of environmental contaminants and potentially for the application in large-scale wastewater treatment plants.</P>

Promising efficiency enhancement in cobalt redox couple-based back-illuminated dye-sensitized solar cells with titanium foil substrate

Kim, Myoung,Yun, Ho-Gyeong,Jang, Lee-Woon,Jeon, Dae-Woo,Kang, Man Gu,Yoon, Jeong-Hun,Kim, Ju-Mi,Park, Jong Hyeok,Lee, In-Hwan,Kim, Jeum Jong Elsevier 2015 Journal of Power Sources Vol.278 No.-

<P><B>Abstract</B></P> <P>We demonstrate that a [Co(bpy)<SUB>3</SUB>]<SUP>2+/3+</SUP> (PF<SUB>6</SUB>)<SUB>2/3</SUB> redox couple is an effective strategy for cost-effective and highly efficient dye-sensitized solar cells (DSSCs). Their high transmittance and large complex size make cobalt redox couples advantageous in back-illuminated devices. Furthermore, the use of thin TiO<SUB>2</SUB> films, together with the naturally formed blocking layer at the outermost surface of Ti substrate, effectively alleviate the drawbacks of cobalt electrolyte. By virtue of these simultaneous effects, we achieve a highly promising power conversion efficiency of 7.12%.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Metal foil based dye-sensitized solar cells were prepared with cobalt electrolyte. </LI> <LI> High transmittance and large complex size are advantageous in back-illumination. </LI> <LI> Thin TiO<SUB>2</SUB> film and titanium foil alleviate the shortcomings of the electrolyte. </LI> <LI> A highly promising power conversion efficiency of 7.12% is achieved. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Clinical significance of galectin-7 in epithelial ovarian cancer.

Kim, Ha-Jeong,Jeon, Hye-Kyung,Lee, Jae-Kwan,Sung, Chang Ohk,Do, In-Gu,Choi, Chel Hun,Kim, Tae-Joong,Kim, Byoung-Gie,Bae, Duk-Soo,Lee, Jeong-Won Potamitis Press 2013 Anticancer research Vol.33 No.4

<P>Galectin-7 (GAL-7) has been highlighted as an important marker in many types of cancers by either inhibiting or promoting tumor growth. In this novel study, we assessed the association of GAL-7 with clinicopathological variables and survival outcomes in epithelial ovarian cancer (EOC) and investigated the role of GAL-7 in proliferation of ovarian cancer cell lines.</P>