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RISS 인기검색어
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- 저자 : Houston Deborah (검색결과 2 건)
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Epidemiology and Survival after Spinal Meningioma Surgery: A Nationwide Population-Based Study
Jecko Vincent,Weller Joconde,Houston Deborah,Champeaux-Depond Charles 대한척추외과학회 2022 Asian Spine Journal Vol.16 No.6
Study Design: This is a cross-sectional nationwide descriptive observational and analytic retrospective study.Purpose: This study aims to describe and assess survival after spinal meningioma (SM) surgery.Overview of Literature: A few studies report a reduced survival after SM surgery.Methods: The current study processed the Système National des Données de Santé (SNDS), the French national administrative medical database, to retrieve appropriate cases.Results: This study identified 2,844 patients (79.1% females) between 2008 and 2017. The median age at surgery was 66 years (interquartile range [IQR], 56–75 years). Moreover, 95.9% of SMs were removed through posterior or posterolateral approaches, and 6.9% were epidural and 0.7% needed an associated spine stabilization. Benign meningioma represented 92.9%, with 5% and 2.1% atypical and malignant, respectively. The median follow-up was 3.3 years (IQR, 3.1–3.5 years). Of the patients, 0.25% and 1.2% expired within a month and a year of surgery, respectively. At data collection, 225 patients (7.9%) expired. The 5-year overall survival (OS) probability was 90.1% (95% CI, 88.6%–91.7%). However, absolute excess risk of mortality after SM surgery was null, and the related standardized mortality ratio was 1 (95% CI, 0.9–1.2; <i>p</i> =0.565). In the adjusted regression, age at surgery (hazard ratio [HR], 1.06; 95% CI, 1.04–1.07; <i>p</i> <0.001), level of comorbidities (HR, 1.44; 95% CI, 1.34–1.54; <i>p</i> <0.001), neurofibromatosis type 2 (NF2; HR, 3.65; 95% CI, 1.28–10.39; <i>p</i> =0.0152), epidural SM (HR, 1.73; 95% CI, 1.09–2.75; <i>p</i> =0.0206), and malignant meningioma (HR, 2.64; 95% CI, 1.51–4.61; <i>p</i> <0.001) remained significantly associated to a reduced OS.Conclusions: The SNDS is of great value in assessing SM incidence, associated mortality, and its predictors. OS after meningioma surgery is favorable but may be impaired for NF2 or older patients with a high level of comorbidities, epidural tumor, and malignant histopathology. SM surgery is not associated with an increased absolute excess mortality risk despite being performed on even more senior patients compared with intracranial meningioma.
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Functional Outcome after Spinal Meningioma Surgery
Jecko Vincent,Loit Marie-Pierre,Houston Deborah,Champeaux-Depond Charles 대한척추외과학회 2022 Asian Spine Journal Vol.16 No.5
Study Design: A multicenter cross-sectional analytical retrospective study.Purpose: To assess functional outcome (FO) after a spinal meningioma (SM) surgery. Overview of Literature: All studies report functional improvement after SM removal.Methods: We performed an analytical retrospective cohort study at five different institutions. All patients with a diagnosis of SM were included in this study, including those with recurrent tumors. Meningiomas of the foramen magnum were excluded. Useful histopathological characteristics were separately extracted. Surgical resection was evaluated according to the Simpson grading scale. Patient outcomes and clinical states were assessed with the help of their medical records using four different scales: the modified Ranawat score, the Nurick scale, the Prolo score, the Frankel grade, and the Eastern Cooperative Oncology Group–World Health Organization– Zubrod score.Results: Between 1991 and 2018, 417 patients were identified, of which 85.8% were female. The median age at surgery was 67.2 years (interquartile range [IQR], 56.7–76.5). The lesion was located in the thoracic region in 77.9% of the patients, cervical region in 16.8%, and lumbar region in 4.1%. Surgical resection was complete in 95.5% of the cases. Only 0.96% of the patients died within the first postoperative month. Neurological status, which improved in 76.9% of the patients, was unchanged in 17.5% and even worsened in 4.4%. Functional status was assessed using the Ranawat score and Nurick scale, with scores of 1 (IQR, 0–2) (i.e., hyperreflexia and asymptomatic; mean, 1.3±1.3) and 1 (IQR, 0−2) (i.e., signs of spinal cord disease, but no difficulty in walking; mean, 1.2±1.4), respectively. Approximately 10.1% of the patients were not ambulant at the last neurosurgical follow-up visit. Older age at surgery was not significantly associated with a chair-bound status (<i>p</i> =0.427).Conclusions: This large series confirms the favorable FO after spinal meningioma surgery even in the case of seriously impaired preoperative status. A validated scale is needed to assess the factors predicting a worsening of the functional status and guide the management of patients.
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