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Gas Separation Polysulfone Membranes Modified by Cadmium-based Nanoparticles
Elmira Tavasoli,Morteza Sadeghi,Hossein Riazi,Ahmad Arabi Shamsabadi,Masoud Soroush 한국섬유공학회 2018 Fibers and polymers Vol.19 No.10
This paper presents new mixed-matrix membranes (MMMs) synthesized via incorporating hexamethylenetetramine dicyanamide cadmium nanoparticles, a metal organic framework (MOF), into the polysulfone (PSF) matrix. The MMMs are characterized using FTIR and SEM analyses, and their gas permeation properties are evaluated at different MOF loadings and various pressures. The results show that the nanoparticle is compatible with the polymer and distributes homogenously in the matrix. Compared to the pristine PSF membrane, the MMM with 2.5 wt. % of the MOF nanoparticles has lower CO2, CH4, N2 and O2 permeabilities but significantly higher CO2/CH4, CO2/N2 and O2/N2 gas pair selectivities (i.e., 41.66, 20.08 and 5.09, respectively, which are 42.6, 61.6 and 60.02 % higher). As the total pressure increases, the gas permeabilities of the pristine PSF membrane and the MMMs decrease, but their sieving abilities increase. These results suggest that gas selectivities of high free-volume polymers with poor sieving abilities can be improved by incorporating the MOF into the polymer.
Modification of Substrate Inhibition of Synaptosomal Acetylcholinesterase by Cardiotoxins
Ranaei-Siadat, Seyed-Omid,Riazi, Gholam-Hosein,Sadeghi, Mehdi,Chang, Long-Sen,Lin, Shinne-Ren,Eghtesadi-Araghi, Peyman,Hakimelahi, Gholam Hossein,Moosavi-Movahedi, Ali Akbar Korean Society for Biochemistry and Molecular Biol 2004 Journal of biochemistry and molecular biology Vol.37 No.3
Different types of cardiotoxin (I-V and n) were isolated and purified from the venom of the Taiwan cobra (Naja naja atra). The effects of these cardiotoxins were studied on membrane-bound acetylcholinesterase, which was isolated from a sheep's brain cortex. The results showed that cardiotoxins I-III, V, and n activated the enzyme by modification of substrate inhibition, but cardiotoxin IV's reaction was different. The inhibition and activation of acetylcholinesterase were linked to the functions of the hydrophobicity index, presence of a cationic cluster, and the accessible arginine residue. Our results indicate that Cardiotoxins have neither a cationic cluster nor an arginine residue in their surface area of loop I; therefore, in contrast to fasciculin, cardiotoxins are attached by loop II to the peripheral site of the enzyme. As a result, fasciculin seems to stabilize nonfunctional conformation, but cardiotoxins seem to stabilize the functional conformation of the enzyme. Based on our experimental and theoretical findings, similar secondary and tertiary structures of cardiotoxins and fasciculin seem to have an opposite function once they interact with acetylcholinesterase.
Mahshid Nikpour Nezhati,Gholam Hossein Riazi,Homayon Ahmad Panahi,Elham Moniri,Nasir Ahmad Rajabi,Mohammad Mehdi Sadughi,Natasha Rahmani Zaker,Robab Ardekani,Reihaneh Kooshkestani 한국화학공학회 2013 Korean Journal of Chemical Engineering Vol.30 No.3
The sodium salt of di ((1-hydroxy-2-benzothiazolium-1-yl) ethyliden-1,1-H-bisphosphonic acid) orthophosphate was synthesized and its toxicity and viability effects screened on two different human neuroblastoma cell lines. This novel derivative of benzothiazole provides a new compound in connection with research and therapeutic application for tumor cell growth inhibition. Benzothiazole was alkylated in reaction with bromoacetic acid and then converted to its H-bisphosphonic acid derivative in presence of H3PO3/POCl3. The procedure led to formation of two molecules of corresponding H-bisphosphonic acid which attached together via a phosphate bridge. The investigated compound exhibits activities (IC50 value) ranging from 14-23 μM (corresponding to human neuroblastoma SK-BE (2)and SK-NM-C cells).
Modification of Substrate Inhibition of Synaptosomal Acetylcholinesterase by Cardiotoxins
( Seyed Omid Ranaei Siadat ),( Gholam Hosein Riazi ),( Mehdi Sadeghi ),( Long Sen Chang ),( Shinne Ren Lin ),( Peyman Eghtesadi Araghi ),( Gholam Hossein Hakimelahi ),( Ali Akbar Moosavi Movahedi ) 생화학분자생물학회 2004 BMB Reports Vol.37 No.3
Different types of cardiotoxin (I-V and n) were isolated and purified from the venom of the Taiwan cobra (Naja naja atra). The effects of these cardiotoxins were studied on membrane-bound acetylcholinesterase, which was isolated from a sheep`s brain cortex. The results showed that cardiotoxins I-III, V, and n activated the enzyme by modification of substrate inhibition, but cardiotoxin IV`s reaction was different. The inhibition and activation of acetylcholinesterase were linked to the functions of the hydrophobicity index, presence of a cationic cluster, and the accessible arginine residue. Our results indicate that Cardiotoxins have neither a cationic cluster nor an argininge residue in their surface area of loop I; therefore, in contrast to fasciculin, cardiotoxins are attached by loop II to the peripheral site of the enzyme. As a result, fasciculin seems to stabilize nonfunctional conformation, but cardiotoxins seem to stabilize the functional conformation of the enzyme. Based on our experimental and theoretical findings, similar secondary and tertiary structures of cardiotoxins and fasciculin seem to have an opposite function once they interact with acetylcholinesterase. s