Carbon-based layer-by-layer nanostructures: from films to hollow capsules

Hong, Jinkee,Han, Jung Yeon,Yoon, Hyunsik,Joo, Piljae,Lee, Taemin,Seo, Eunyong,Char, Kookheon,Kim, Byeong-Su Royal Society of Chemistry 2011 Nanoscale Vol.3 No.11

<P>Over the past years, the layer-by-layer (LbL) assembly has been widely developed as one of the most powerful techniques to prepare multifunctional films with desired functions, structures and morphologies because of its versatility in the process steps in both material and substrate choices. Among various functional nanoscale objects, carbon-based nanomaterials, such as carbon nanotubes and graphene sheets, are promising candidates for emerging science and technology with their unique physical, chemical, and mechanical properties. In particular, carbon-based functional multilayer coatings based on the LbL assembly are currently being actively pursued as conducting electrodes, batteries, solar cells, supercapacitors, fuel cells and sensor applications. In this article, we give an overview on the use of carbon materials in nanostructured films and capsules prepared by the LbL assembly with the aim of unraveling the unique features and their applications of carbon multilayers prepared by the LbL assembly.</P> <P>Graphic Abstract</P><P>This Feature Article reports the nanostructured carbon films and capsules prepared by layer-by-layer assembly with an aim of unraveling the unique features and their applications. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1nr10575b'> </P>

Multilayer thin film coatings capable of extended programmable drug release: application to human mesenchymal stem cell differentiation.

Hong, Jinkee,Alvarez, Luis M,Shah, Nisarg J,Griffith, Linda G,Kim, Byeong-Su,Char, Kookheon,Hammond, Paula T Springer US 2012 Drug delivery and translational research Vol.2 No.5

<P>The promise of cellular therapy lies in healing damaged tissues and organs in vivo as well as generating tissue constructs in vitro for subsequent transplantation. Adult stem cells are ideally suited for cellular therapies due to their pulripotency and the ease with which they can be cultured on novel functionalized substrates. Creating environments to control and successively driving their differentiation toward a lineage of choice is one of the most important challenges of current cell-based engineering strategies. In recent years, a variety of biomedical platforms have been prepared for stem cell cultures, primarily to provide efficient delivery of growth or survival factors to cells and a conducive microenvironment for their growth. Here, we demonstrate that repeating tetralayer structures composed of biocompatible poly(methacrylic acid) (PMAA)/poly(acryl amide) (PAAm)/poly(methacrylic acid) (PMAA)/poly(ethylene oxide)-block-poly(ε-caprolactone) (PEO-b-PCL) micelles arrayed in layer-by-layer (LbL) films can serve as a payload region for dexamethasone (dex) delivery to human mesenchymal stem cells (MSCs). This architecture can induce MSC differentiation into osteoblasts in a dose-dependent manner. The amount of dex loaded in the films is controlled by varying the deposition conditions and the film thickness. Furthermore, release of dex is also controlled by changing the amount of covalent crosslinking of multilayers via thermal treatments. The multilayer architecture including payload and cell-adhesion region introduced here are well suited for extended cell culture thus affording the important and protective effect of both dex release and immobilization. These films may find applications in the local delivery of immobilized therapeutics for biomedical applications, as they can be deposited on a wide range of substrates with different shapes, sizes, and composition.</P>

Multilayer Nanoplatforms within Functional Nano-Structures for Stem Cell Technology

Jinkee Hong 한국생물공학회 2013 한국생물공학회 학술대회 Vol.2013 No.4

Inherent Charge-Shifting Polyelectrolyte Multilayer Blends: A Facile Route for Tunable Protein Release from Surfaces

Hong, Jinkee,Kim, Byeong-Su,Char, Kookheon,Hammond, Paula T. American Chemical Society 2011 Biomacromolecules Vol.12 No.8

<P>Recent research has highlighted degradable multilayer films that enable the programmed release of different therapeutics. Multilayers constructed by the layer-by-layer (LbL) deposition that can undergo disassembly have been demonstrated to be of considerable interest, particularly for biomedical surface coatings due to their versatility and mild aqueous processing conditions, enabling the inclusion of biologic drugs with high activity. In this study, we examine the controlled release of a protein using a different mechanism for film disassembly, the gradual dissociation of film interactions under release conditions. Poly(β-amino ester)s and poly(<SMALL>l</SMALL>-lysine) (PLL) were used as the positively charged multilayer components coassembled with a model negatively charged antigen protein, ovalbumin (Ova). The release of the protein from these multilayer films is dominated by the slow shift in the charge of components under physiological pH conditions rather than by hydrolytic degradative release. The time scale of release can be varied over almost 2 orders of magnitude by varying the ratio of the two polyamines in the deposition solution. The highly versatile and tunable properties of these films form a basis for designing controlled and sequential delivery of drug coatings using a variety of polyions.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bomaf6/2011/bomaf6.2011.12.issue-8/bm200566k/production/images/medium/bm-2011-00566k_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/bm200566k'>ACS Electronic Supporting Info</A></P>

Controlled release of bFGF from nano-coating for maintaining undifferentiated human iPS cells

Jinkee HONG,Uiyoung HAN 한국생물공학회 2016 한국생물공학회 학술대회 Vol.2016 No.10

체육과 무(武), 국가 번영의 기초

홍영기(Youngki Hong),홍진기(Jinkee Hong) 한국콘텐츠학회 2018 한국콘텐츠학회논문지 Vol.18 No.7

플라톤의 존재론은 물질과 정신의 영역을 독립적으로 간주하는 이원론보다는, 이데아를 중심으로 하는 전체론(Holism)에 가깝다. 그의 형이상학에서 감각적 사물은 이데아의 모상이며, 이데아는 그것의 원형이다. 그에 따라 인간의 육체와 영혼도 서로 단절된 것이 아니라, 존재론적으로 연속적이며 기능적으로 상보적인 관계에 놓여있다. 영혼의 완성을 추구하는 플라톤의 교육관에서 체육을 중시하며 그것을 공부의 전제로 삼은 이유는 이러한 존재론에 근거한 것이다. 구한말 독립운동가 박은식 역시 플라톤과 비슷한 교육관을 지니고 있는 것으로 보인다. 그는 우리 민족이 회복해야 하는 내면의 가치인 `마음`을 발견하기 위해선, 무(武)의 교육이 중요함을 역설하였다. 플라톤과 박은식 모두는 체육과 무(武)의 교육이 그들이 추구했던 인간상을 만들기 위한 공부의 전제가 된다고 보았다. 그리고 그들이 제시한 교육과정을 통해 육성된 인재들은 사회에서 각자 자신의 직분을 다함으로써 국가의 번영을 이끌 것이라 기대했다. 결론적으로, 플라톤과 박은식의 사상에서 학생들에 대한 체육과 무(武)의 교육은 인간의 개인적 완성을 위한 공부의 전제이자, 그들이 꿈꾸었던 이상국가를 만들기 위한 필수적 교육과정 이었다고 할 수 있다. Plato’s ontology is closer to Holism, which is based on IDEA, than to Dualism, which regards the matter and soul as being independently from each other. According to his metaphysics, the sensory things are the copies of IDEA. and IDEA is the original of them. Hence human body and soul are not separate from each other, but are ontologically continuous and functionally complementary. The reason why Platos view of education, which pursues the perfection of the soul, emphasizes the physical training and makes it the premise of study is this ontology. It seems that Park Eun-sik, an independent activist in the late period of Joseon Dynasty, has a view of education similar to Plato’s. He emphasized the importance of education on martial art in order to restore the our peoples inner quality, Mind(心). Both Plato and Park Eun-sik thoughts that the education of physical training and martial art was the premise of study to make the humanity they pursued. And they expected that the talented people raised through the curriculum proposed by them would lead the prosperity of the nation by fulfilling their respective roles in society. In conclusion, from the view of Plato and Park Eun-sik’s thoughts, it can be said that, the education of physical training and martial art for students is the premise of the study for personal perfection of human beings, and essential curriculum for making the ideal state that they dreamed.

CHARACTERIZATION OF THE WEIGHTED LIPSCHITZ FUNCTION BY THE GARSIA-TYPE NORM ON THE UNIT BALL

Cho, Hong Rae,Kwon, Su-Mi,Lee, Jinkee Mathematical Society of the Republic of China (Tai 2008 Taiwanese journal of mathematics Vol.12 No.3

APPROXIMATION BY HOLOMORPHIC FUNCTIONS ON PSEUDOCONVEX COMPLEX MANIFOLDS

Lee, Jinkee,Cho, Hong Rae 대한수학회 1995 대한수학회보 Vol.32 No.2

Mechanical Stability Improvement of Cell Sheet through Layer-by-layer Technique Application

Miso Yang,Jinkee Hong 한국고분자학회 2016 한국고분자학회 학술대회 연구논문 초록집 Vol.41 No.2

Layer-by-layer assembly of multilayer films for controlled drug release

Choi, Daheui,Hong, Jinkee 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.1

Drug efficacy has been improved using various methods that enhance targeting, decrease toxicity, and facilitate timely and sustained drug release. To achieve these properties, various drug loading and release platforms have been developed. Layer-by-layer (LbL) self-assembly is widely used to generate controlled and sustained drug release LbL multilayer films because it allows desired functions and structures to be obtained through a simple procedure. In this review article, we highlight controlled drug release from LbL self-assembling films with diverse release kinetics, particularly with regard to mechanisms of drug release.