http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
신현경(HYUN-KYOUNG SHIN),주현태(HYUN-TAE JOO),박민호(MIN-HO PARK),박경민(KYOUNG-MIN PARK),김진영(JIN-YOUNG KIM),임진영(JIN-YOUNG LIM) 한국해양공학회 2006 韓國海洋工學會誌 Vol.20 No.1
Experimental research was undertaken to develop a domestic spray nozzle used on equipment for desalination. First, we made a test set-up in order to confirm nozzle efficiency of spray and distribution under different pressure conditions. Then, we found a maximum spray condition after verifying reliability of this facility. An optimum arrangement of the nozzle, based on the test result, was made using CATIA V5 and EXCEL.
Mbd2-CP2c loop drives adult-type globin gene expression and definitive erythropoiesis
Kim, Min ,Young,Kim, Ji ,Sook,Son, Seung ,Han,Lim, Chang ,Su,Eum, Hea ,Young,Ha, Dae ,Hyun,Park, Mi ,Ae,Baek, Eun ,Jung,Ryu, Buom-Yong,Kang, Ho ,Chul,Uversky, Vladi Oxford University Press 2018 Nucleic acids research Vol.46 No.10
<P><B>Abstract</B></P><P>During hematopoiesis, red blood cells originate from the hematopoietic stem cell reservoir. Although the regulation of erythropoiesis and globin expression has been intensively investigated, the underlining mechanisms are not fully understood, including the interplay between transcription factors and epigenetic factors. Here, we uncover that the Mbd2-free NuRD chromatin remodeling complex potentiates erythroid differentiation of proerythroblasts via managing functions of the CP2c complexes. We found that both Mbd2 and Mbd3 expression is downregulated during differentiation of MEL cells <I>in vitro</I> and in normal erythropoiesis in mouse bone marrow, and Mbd2 downregulation is crucial for erythropoiesis. In uninduced MEL cells, the Mbd2-NuRD complex is recruited to the promoter via Gata1/Fog1, and, via direct binding through p66α, it acts as a transcriptional inhibitor of the CP2c complexes, preventing their DNA binding and promoting degradation of the CP2c family proteins to suppress globin gene expression. Conversely, during erythropoiesis <I>in vitro</I> and <I>in vivo</I>, the Mbd2-free NuRD does not dissociate from the chromatin and acts as a transcriptional coactivator aiding the recruitment of the CP2c complexes to chromatin, and thereby leading to the induction of the active hemoglobin synthesis and erythroid differentiation. Our study highlights the regulation of erythroid differentiation by the Mbd2-CP2c loop.</P>