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Miyu Tanaka,Yuta Yoshino,Shogo Takeda,Kazuya Toda,Hiroshi Shimoda,Kazuhiro Tsuruma,Masamitsu Shimazawa,Hideaki Hara 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.10
Sarcopenia, loss of muscle mass and function, is mainly observed in elderly people. In this study, we investigated whether fermented rice germ extract (FRGE) has some effects on the mouse gastrocnemius muscle by using behavioral and morphological analyses, Western blotting, and a murine model of immobilization-induced muscle atrophy. Daily oral FRGE administration increased muscle weight and strength. In addition, myofiber size in gastrocnemius muscle of FRGE-treated mice was increased as revealed by morphological quantification. Activation of AMP-activated protein kinase (AMPK) signaling, which inhibits protein synthesis and stimulates protein degradation in gastrocnemius muscle, was significantly attenuated in the FRGE-treated mice compared with control mice. Expression level of forkhead box 3a (FOXO3a) protein was also significantly decreased in the FRGE-treated group. Moreover, the decrease in mean myofiber cross-sectional area in immobilized hindlimb in vehicle-treated mice was inhibited by FRGE treatment in histological analysis. In conclusion, FRGE increased the strength and weight of gastrocnemius muscle and myofiber size, and reduced immobilization-induced muscle atrophy in mice. These findings indicated that FRGE might be beneficial in preventing motor dysfunction in a range of conditions, including sarcopenia.
Optical and Near-infrared Polarimetry of Non-periodic Comet C/2013 US10 (Catalina)
Kwon, Yuna Grace,Ishiguro, Masateru,Kuroda, Daisuke,Hanayama, Hidekazu,Kawabata, Koji S.,Akitaya, Hiroshi,Nakaoka, Tatsuya,Itoh, Ryosuke,Toda, Hiroyuki,Yanagisawa, Kenshi,Lee, Myung Gyoon,Ohta, Kouji American Institute of Physics 2017 The Astronomical journal Vol.154 No.4
<P>We present an optical and near-infrared (hereafter NIR) polarimetric study of a comet C/2013 US10 (Catalina) observed on UT 2015 December 17-18 at phase angles of alpha - 52 degrees.1-53 degrees.1. Additionally, we obtained an optical spectrum and multi-band images to examine the influence of gas emission. We find that the observed optical signals are significantly influenced by gas emission; that is, the gas-to-total intensity ratio varies from 5 to 30% in the RC and 3%-18% in the I-C bands, depending on the position in the coma. We derive the 'gas-free dust polarization degrees' of 13.8% +/- 1.0% in the RC and 12.5% +/- 1.1% in the IC bands and a gray polarimetric color, i.e., -8.7% +/- 9.9% mu m(-1) in optical and 1.6% +/- 0.9% mu m(-1) in NIR. The increments of polarization obtained from the gas correction show that the polarimetric properties of the dust in this low-polarization comet are not different from those in high-polarization comets. In this process, the cometocentric distance dependence of polarization has disappeared. We also find that the RC-band polarization degree of the southeast dust tail, which consists of large dust particles (100 mu m(-1) mm), is similar to that in the outer coma where small and large ones are mixed. Our study confirms that the dichotomy of cometary polarization does not result from the difference of dust properties, but from depolarizing gas contamination. This conclusion can provide a strong support for similarity in origin of comets.</P>