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Hawaibam Birla SINGH,Moonhyuk KWON,Seon-Won KIM 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Carotenoids, a group of widely distributed natural products, are extensively utilized in food, pharmacological, and nutraceutical industries. Recently microbial bio-carotenoids production is gaining much interest because of its fast, safe, and varying ability to produce different types of carotenoids using various carbon sources. In this study, Methylobacterium organophilum DSM-760, a pink pigmented, fast-growing facultative methylotroph, was selected for carotenoid production using methanol as a sole carbon source. The native carotenoid accumulation was significantly increased with the MEP pathway augmentation via overexpression of the bottleneck genes (1-Deoxy-D-xylulose 5-phosphate synthase (dsx) and 2-C-methylerythritol 4-phosphate reductoisomerase (dxr)) under the strong promoter PmxaF. Furthermore, the overexpression of methylotrophic carotenogenic genes, along with deletion of carotenoid hydroxylating genes like crtC and crtD, increased the native carotenoids accumulation up to 10 folds. Our results highlight that M. organophilum DSM-760 is a potential microbial platform for producing valuable carotenoids using inexpensive and viable carbon feedstock such as methanol. This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2021R1A5A8029490).
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