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Development of an Artificial Tracheal Prosthesis: a Semicircular Shape Polyurethane Scaffold
HanSuKim,HwalSuh,JaHyunLee,JaeHyungKim,DongEunSong,InhoJo,SungMinChung,JaeYolLim,HaeSangPark,HyunJiKim 한국조직공학·재생의학회 2011 조직공학과 재생의학 Vol.8 No.5
The purpose of this study is to develop an artificial prosthesis for reconstruction of a partial tracheal defect. Experimental animal study. A semicircular shape bi-layered (inner: porous, outer: dense) scaffold was made from polyurethane (PU). Polyethylene glycol was grafted onto the inner surface of the PU scaffold to act as a surfactant. Variable sized scaffolds (2×1, 2×2, 3×1, 3×2 and 3×3 cm2) were transplanted into ten beagles. Endoscopic and histological examinations were performed monthly (From 1 month to 6 month after transplantation). Scanning electron microscopy was performed to evaluate the ultrastructure. The measurement of trachea cilia beat frequency was carried out. The tensile strength was measured for evaluation the biomechanical property of the prosthesis. Seven out of the ten beagles survived to the expected date. The endoscopic examination showed granulation tissue on the scaffold transplanted site until one week after transplantation. The mucosa was completely covered after four weeks. The histological examination showed that a large amount of fibrous tissue had grown through pores of the porous scaffold. Ciliated respiratory mucosa was restored onto the surface of the PU scaffold, as visualized by scanning electron microscopy. About 16 -20 Hz cilia beat frequency was noted on the functional exam. The tensile stress (the stress strain curve) of the scaffold transplanted site was very similar with that of the normal cartilage. The semicircular shape PU scaffold could be used as a ready-made type prosthesis for tracheal reconstruction.
Effect of Antioxidants on Arsenite Exposed Porcine Embryonic Development
Han-Su Kim,Yu-Sub Lee,Sang-Hee Lee,Hee-Tae Cheong,Choon-Keun Park,Seunghyung Lee,Boo-Keun Yang 대한의생명과학회 2017 Biomedical Science Letters Vol.23 No.1
This study was to investigate the role of antioxidants on development in arsenite exposed porcine embryos. Oocytes were collected from porcine ovary, and then matured for 44 h. Maturated oocytes were incubated with sperm for 6 h, and fertilized oocytes with sperm (embryos) cultured for 48 h. After, embryos were culture with arsenite and/or antioxidants (melatonin, silymarin, curcumin and vitamin) for 120 h. Formation of pre-morulae, morulae and blastosysts rate was measured using microscope. In results, 10, 100 and 100 nM arsenite significantly decreased morulae and blastocysts formation compared to control in pigs (P<0.05). 10 μM silymarin and 100 μM vitamin E increased blastocyst formation compared to 10 nM arsenite exposed embryos, but there were no significantly among the treatment, and 1 nM melatonin and 5 μM curcumin did not influence blastocysts formation in 10 nM arsenite exposed embryos. In summary, arsenite decreased embryo development, 10 μM silymarin, 100 μM vitamin E, 1 nM melatonin and 5 μM curcumin had no positive effect to blastocyst formation in arsenite exposed porcine embryos. Therefore, we suggest that little arsenite may have negative effect to embryo development, and silymarin, vitamin E, melatonin and curcumin could not rescue embryo development from damage by arsenite in pigs.
( Han Su Kim ),( Eun Byul Cho ),( Eun Joo Park ),( Kwang Ho Kim ),( Kwang Joong Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Vitiligo with white hairs(Leukotrichia) is very common in segmental vitiligo, and repigmentation by photochemotherapy is usually difficult because of a deficient melanocyte reservoir. Objectives: In this study, we checked the leukotrichia in patients with vitiligo, and then evaluated the effect of treatment by excimer laser according to the presence of leukotrichia. Methods: We treated 36 vitiligo patients by excimer laser. Before treatment, we checked leukotrichia by dermoscopy. At the beginning and 6 months later, we took a clinical pictures and evaluated the degrees of repigmentation by grade 1 to 4(1:0~25% repigmentation, 2:25~50%, 3:50~75%, 4:75~100%). Results: This trial involved total 36 patients with vitiligo and 11 of 36 patients were with segmental vitiligo. 8 patients(73%) showed leukotrichia but all of patients with segmental vitiligo showed poor response(grade 2 or less) after treatment regardless of leukotrichia. On the other hand, 25 of 36 patients showed non-segmental vitiligo, and 8 of 25 patients(32%) had leukotrichia. All 8 patients with leukotrichia didn`t show good response(grade 3 or more) to excimer. 4 of 17 patients(23.5%) without leukotrichia showed good response to excimer. Conclusion: We found that all patients with leukotrichia showed poor response to phototherapy. Based on these findings, we assumed that confirming the presence of leukotrichia before treatment whould be helpful to expect the prognosis of treatment.