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RISS 인기검색어
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- 저자 : Hamideh Saravani (검색결과 3 건)
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Protein Expression of Stromelysin-2 in Head and Neck Squamous Cell Carcinomas
Kadeh, Hamideh,Heydari, Fatemeh,Saravani, Shirin,Ghodsi, Iman Najafi Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.17
Background: Some matrix metalloproteinases (MMPs) are involved in invasion and metastasis of head and neck squamous cell carcinoma (HNSCC). However, there are few studies on association between stromelysin-2 (ST-2) and invasive behavior of HNSCC. The purpose of this study was to investigate Stromelysin-2 expression by immunohistochemistry. Materials and Methods: This study was conducted on 81 specimens, including 61 HNSCC and 20 non neoplastic epithelium. Sections with 5 micron thickness were prepared and stained with immunohistochemistry technique. Then expression of ST-2 was evaluated according to percentage of stained cells and intensity of staining. Data were analyzed by SPSS (V.21) using Kruskal-Wallis and Tukey tests (P<0.05). Results: The 61 HNSCC specimens were grades I 36.1%, II 34.4% and III 29.5%. The level of ST-2 expressions were moderate (++) and intensive (+++) in 21.3% and 78.7% of tumors, respectively. The ST-2 expression level was only significant between the tumors with grade I and grade III (P=0.016). Tumors presented ST-2 expression with staining intensity of mild 6.6%, moderate 26.2% and strong 67.2%. Staining intensity of ST-2 in grade I tumors was significantly lower than grade II and grade III (P<0.05), and there was no significant difference between grades II and III (P=0.99). Conclusions: According to this study, the expression of ST-2 is associated with histopathological grade and tumor differentiation in HNSCCs.
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Kadeh, Hamideh,Saravani, Shirin,Heydari, Fatemeh,Keikha, Mohammad,Rigi, Vahab Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15
Background: Matrix metalloproteinases (MMPs) are a family of zinc metalloproteinases capable of degrading components of connective tissues. MMP-10 is frequently expressed in human cancers. The aim of this study was to immunohistochemically evaluate its expression in oral squamous cell carcinoma (OSCC) and verrucous carcinoma (OVC). Materials and Methods: A retrospective analysis of 73 samples (31 OSCC, 22 OVC and 20 non-neoplastic epithelium) was performed. All samples were immunohistochemically stained with monoclonal MMP-10 antibody and expression levels and staining intensity were evaluated with respect to microscopic features. Data were analyzed by SPSS (V.21), Mann-Whitney and Kruskal Wallis tests. Results: MMP-10 was detected in all OSCC and OVC cases. The expression of MMP-10 in OSCC was intensive (score 3) and in OVC was low and moderate (score 1 and score 2) more frequently. Non- neoplastic epithelium did not show MMP-10 expression. Differences between groups was statistically significant (p<0.05). However, the expression of MMP-10 was not obviously different between various grades of OSCC. Conclusions: According to our study, MMP-10 protein can be important possible factor in the transformation of normal oral epithelium to OVC and OSCC, also the level of MMP-10 expression at invasion front of the lesions can be helpful in the differentiation of OVC and OSCC.
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Omid Sayar,Niloufar Akbarzadeh Torbati,Hamideh Saravani,Kheirollah Mehrani,Ali Behbahani,Hamid Reza Moghadam Zadeh 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.5
In this work a novel ion imprinted polymer (IIP) based on 4-(vinylamino)pyridine-2,6-dicarboxylicacid (VPyDC), was coated on Fe3O4 nano-particles. The application of this magnetic sorbent was investigated for preconcentration and determination of trace Pb(II) ions by flame atomic absorption spectrometry. Effects of various parameters such as sample pH, adsorption/desorption time and eluent were investigated during this study. The relative standard deviation and limit of detection of the method were found to be 1.8% and 0.9 ng mL 1, respectively. The accuracy of this method was confirmed using various standard reference materials, then it was used for Pb(II) determination in environmental samples.
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