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혼합 모델 및 다중 가설 검정을 이용한 신호와 잡음의 분리
Hae-sang Park,Si-Won Yoo,Chi-Hyuck Jun 한국경영과학회 2009 한국경영과학회 학술대회논문집 Vol.2009 No.5
It is necessary to separate the signal and noise in quantitative analysis of inclusion using optical emission spectroscopy data. It is assumed that the noise follows a Gaussian distribution and the signal follows a Gamma distribution, thus the underlying distribution of data will be a mixture of Gaussian and Gamma distribution. The parameters of the mixture model can be estimated from the EM algorithm. Then the signals and noises will be classified by using a fixed threshold approach based on multiple testing using positive false discovery rate and Bayes error. The proposed method is applied to a real data and a simulation is carried out to compare the performance with the previous method like 3 sigma rule.
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혼합 모델 및 다중 가설 검정을 이용한 신호와 잡음의 분리
Hae-sang Park,Si-Won Yoo,Chi-Hyuck Jun 대한산업공학회 2009 대한산업공학회 춘계학술대회논문집 Vol.2009 No.5
It is necessary to separate the signal and noise in quantitative analysis of inclusion using optical emission spectroscopy data. It is assumed that the noise follows a Gaussian distribution and the signal follows a Gamma distribution, thus the underlying distribution of data will be a mixture of Gaussian and Gamma distribution. The parameters of the mixture model can be estimated from the EM algorithm. Then the signals and noises will be classified by using a fixed threshold approach based on multiple testing using positive false discovery rate and Bayes error. The proposed method is applied to a real data and a simulation is carried out to compare the performance with the previous method like 3 sigma rule.
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Development of an Artificial Tracheal Prosthesis: a Semicircular Shape Polyurethane Scaffold
HanSuKim,HwalSuh,JaHyunLee,JaeHyungKim,DongEunSong,InhoJo,SungMinChung,JaeYolLim,HaeSangPark,HyunJiKim 한국조직공학·재생의학회 2011 조직공학과 재생의학 Vol.8 No.5
The purpose of this study is to develop an artificial prosthesis for reconstruction of a partial tracheal defect. Experimental animal study. A semicircular shape bi-layered (inner: porous, outer: dense) scaffold was made from polyurethane (PU). Polyethylene glycol was grafted onto the inner surface of the PU scaffold to act as a surfactant. Variable sized scaffolds (2×1, 2×2, 3×1, 3×2 and 3×3 cm2) were transplanted into ten beagles. Endoscopic and histological examinations were performed monthly (From 1 month to 6 month after transplantation). Scanning electron microscopy was performed to evaluate the ultrastructure. The measurement of trachea cilia beat frequency was carried out. The tensile strength was measured for evaluation the biomechanical property of the prosthesis. Seven out of the ten beagles survived to the expected date. The endoscopic examination showed granulation tissue on the scaffold transplanted site until one week after transplantation. The mucosa was completely covered after four weeks. The histological examination showed that a large amount of fibrous tissue had grown through pores of the porous scaffold. Ciliated respiratory mucosa was restored onto the surface of the PU scaffold, as visualized by scanning electron microscopy. About 16 -20 Hz cilia beat frequency was noted on the functional exam. The tensile stress (the stress strain curve) of the scaffold transplanted site was very similar with that of the normal cartilage. The semicircular shape PU scaffold could be used as a ready-made type prosthesis for tracheal reconstruction.
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