Systematic Review of Available Guidelines on Fertility Preservation of Young Patients with Breast Cancer

Haddadi, Mahnaz,Muhammadnejad, Samad,Sadeghi-Fazel, Fariba,Zandieh, Zahra,Rahimi, Gohar,Sadighi, Sanambar,Akbari, Parya,Mohagheghi, Mohammad-Ali,Mosavi-Jarrahi, Alireza,Amanpour, Saeid Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.3

Background: Since the survival rate of breast cancer patients has improved, harmful effects of new treatment modalities on fertility of the young breast cancer patients has become a focus of attention. This study aimed to systematically review and critically appraise all available guidelines for fertility preservation in young breast cancer patients. Materials and Methods: Major citation databases were searched for treatment guidelines. Experts from relevant disciplines appraised the available guidelines. The AGREE II Instrument that includes 23 criteria in seven domains (scope and purpose of the guidelines, stakeholder involvement, rigor of development, clarity, applicability, editorial independence, and overall quality) was used to apprise and score the guidelines. Results: The search strategy retrieved 2,606 citations; 72 were considered for full-text screening and seven guidelines were included in the study. There was variability in the scores assigned to different domains among the guidelines. ASCO (2013), with an overall score of 68.0%, had the highest score, and St Gallen, with an overall score of 24.7%, had the lowest scores among the guidelines. Conclusions: With the promising survival rate among breast cancer patients, more attention should be given to include specific fertility preservation recommendations for young breast cancer patients.

QTL analysis of agronomic traits in recombinant inbred lines of sunflower under partial irrigation

Haddadi, P.,Yazdi-Samadi, B.,Naghavi, M.R.,Kalantari, A.,Maury, P.,Sarrafi, A. The Korean Society of Plant Biotechnology 2011 Plant biotechnology reports Vol.5 No.2

The objective of the present research was to map QTLs associated with agronomic traits such as days from sowing to flowering, plant height, yield and leaf-related traits in a population of recombinant inbred lines (RILs) of sunflower (Helianthus annuus). Two field experiments were conducted with well-irrigated and partially irrigated conditions in randomized complete block design with three replications. A map with 304 AFLP and 191 SSR markers with a mean density of 1 marker per 3.7 cM was used to identify QTLs related to the studied traits. The difference among RILs was significant for all studied traits in both conditions. Three to seven QTLs were found for each studied trait in both conditions. The percentage of phenotypic variance ($R^2$) explained by QTLs ranged from 4 to 49%. Three to six QTLs were found for each yield-related trait in both conditions. The most important QTL for grain yield per plant on linkage group 13 (GYP-P-13-1) under partial-irrigated condition controls 49% of phenotypic variance ($R^2$). The most important QTL for 1,000-grain weight (TGW-P-11-1) was identified on linkage group 11. Favorable alleles for this QTL come from RHA266. The major QTL for days from sowing to flowering (DSF-P-14-1) were observed on linkage group 14 and explained 38% of the phenotypic variance. The positive alleles for this QTL come from RHA266. The major QTL for HD (HD-P-13-1) was also identified on linkage group 13 and explained 37% of the phenotypic variance. Both parents (PAC2 and RHA266) contributed to QTLs controlling leaf-related traits in both conditions. Common QTL for leaf area at flowering (LAF-P-12-1, LAF-W-12-1) was detected in linkage group 12. The results emphasise the importance of the role of linkage groups 2, 10 and 13 for studied traits. Genomic regions on the linkage groups 9 and 12 are specific for QTLs of leaf-related traits in sunflower.

Effect of growing media on morpho-physiological quality attributes of Tetraclinis articulata seedlings

El Haddadi Rachid,El Mekkaoui Abdelalli,Zouahri Abdelmjid,Ouazzani Touhami Amina,Douira Allal 한국산림과학회 2022 Forest Science And Technology Vol.18 No.3

Tetraclinis articulata (Vahl.) Master or thuya is facing several constraints to its successful nat- ural regeneration in Morocco. Containerized seedlings plantation is the only method adopted in thuya forest restoration programs and post-transplant water stress produces high seedling mortality after the first summer following outplanting. There is thus a real need to improve nursery seedlings quality, especially enhancing the growth of the root sys- tem by improving the water holding capacity of the root plug. Our aim was to assess the effects of clay on the water holding capacity of the growing media and on various morpho- logical and physiological traits of T. articulata seedlings in the nursery. T.articula seedlings were raised in nursery using nine composite substrates; seedlings quality was evaluated according to their morpho-physiological and performance attributes. This investigation determined that a clay content of 20–25% constitutes an optimum for obtaining seedlings with a good root growth potential and high root viability. Excessive clay content in the growing media resulted in water-logged root plug decreasing root growth potential. This investigation found that morphological attribute as Root Collar Diameter and Root/Shoot ratio could be considered good predictors of Root Growth Potential.

Structural and Magnetic Properties of Mechanochemically Prepared Li Ferrite Nanoparticles

M. Haddadi,M. Mozaffari,J. Amighian 한국자기학회 2017 Journal of Magnetics Vol.22 No.2

In this work, lithium ferrite (Li0.5Fe2.5O₄) nanoparticles were prepared via mechanochemical processing and subsequent heat treatment at a relatively low (600 ℃) calcining temperature. The raw materials used were high purity Fe₂O₃ and Li₂CO₃ that were milled for between 2 and 20 h. The milled powders were then calcined at temperatures of 500 and 600 ℃ for 5 h in air. XRD results show that optimum conditions to obtain single phase lithium ferrite nanoparticles with a mean crystallite size of about 23 ㎚, using Scherrer’s formula, are 10 h milling and calcination at 600 ℃. Saturation magnetization and coercivity of the single phase Li ferrite nanoparticles are 44.6 emu/g and 100 Oe respectively, which are both smaller than those of the bulk Li ferrite. The Curie temperature of the single sample was determined by a Faraday balance, which is 578 ℃ and smaller than that of bulk Li ferrite.

Cadmium removal from aqueous solutions by pumice and nano-pumice

Sara Haddadi Khorzughy,Teymur Eslamkish,Faramarz Doulati Ardejani,Mohammad Reza Heydartaemeh 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.1

Use of low-cost minerals to eliminate mining and industrial pollutants is the main goal of this study. Weinvestigated the ability of pumice and nano-pumice to remove cadmium from a synthetic aqueous solution. Batchexperiments were performed to investigate adsorption characteristic; therefore, the effective factors influencing theadsorption process including solution pH, contact time and initial concentration have been considered. Equilibriumdata were attempted by Langmuir and Freundlich isotherm models to realize the interaction between adsorbent andadsorbate. The results show that cadmium adsorption on Pumice follows the Langmuir isotherm model with a R2of0.9996 and shows a homogeneous and mono-layer adsorption. Whereas, cadmium adsorption on nano-Pumice fol-lows a Freundlich model (R2=0.9939) and exhibits a multi-layer adsorption. The maximum mono-layer capacity (qmax)of cadmium for pumice and nano-pumice was calculated 26 and 200mg/g, respectively. Two different kinetics modelsincluding pseudo first-order and pseudo second-order were studied to evaluate the rate and mechanism of cadmiumadsorption by pumice and nano-pumice. The kinetics data indicate that a pseudo second-order model provides thebest correlation of the experimental data.

Signs, Symptoms and Complications of Non-Hodgkin's Lymphoma According to Grade and Stage in South Iran

Dehghani, Mehdi,Haddadi, Sara,Vojdani, Reza Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8

Background: Non-Hodgkin's lymphoma (NHL) is a heterogeneous type of neoplasm of the lymphatic system. To have a more accurate and early diagnosis we need to know signs, symptoms and complications of lymphoma in early stages besides pathology and immunohistochemistry. Materials and Methods: This prospective study included 110 cases of NHL that were followed since February 2012 till November 2013. Biopsies were taken from all the patients besides bone marrow study. Signs and symptoms were categorized into "B" symptoms, general, lymphadenopathy and extranodal involvement and we compared the frequencies by stage and grade. Results: Of 110 cases, 88.9% had B-cell and 11.1% T-cell type with mean age $48.5{\pm}18.6$ years. "B" symptoms and lymphadenopathy were more common in men. Cervical lymphadenopathy was the most common sign (44.8%). and hematologic, bone marrow, bone and neurologic lesions were the most common complications. All complications were more common in males. "B" symptoms were seen mostly in stage III, general signs and symptoms in stage IV, and lymphadenopathy in stage II. Intermediate grade was also the most common in all signs and symptoms. In this study 12 (10.9%) patients had relapse, with neurologic and bone marrow as the most common sites of tumor recurrence. Conclusions: There is a meaningful relationship between male gender for NHL and anemia that can be due in part to higher incidence of bone marrow involvement and stage IV disease in male cases. We also found a strong relationship between low grade NHL and age. On the other hand extranodal involvement is more common in female groups.

The World of Connections and Information Flow in Twitter

Meeyoung Cha,Benevenuto, F.,Haddadi, H.,Gummadi, K. IEEE 2012 IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS P Vol.42 No.4

<P>Information propagation in online social networks like Twitter is unique in that word-of-mouth propagation and traditional media sources coexist. We collect a large amount of data from Twitter to compare the relative roles different types of users play in information flow. Using empirical data on the spread of news about major international headlines as well as minor topics, we investigate the relative roles of three types of information spreaders: 1) mass media sources like BBC; 2) grassroots, consisting of ordinary users; and 3) evangelists, consisting of opinion leaders, politicians, celebrities, and local businesses. Mass media sources play a vital role in reaching the majority of the audience in any major topics. Evangelists, however, introduce both major and minor topics to audiences who are further away from the core of the network and would otherwise be unreachable. Grassroots users are relatively passive in helping spread the news, although they account for the 98% of the network. Our results bring insights into what contributes to rapid information propagation at different levels of topic popularity, which we believe are useful to the designers of social search and recommendation engines.</P>

EFFECT OF CARBON NANOTUBES ON THE KINETICS OF IN SITU POLYMERIZATION OF METHYL METHACRYLATE

MEHDI SALAMI-KALAJAHI,VAHID HADDADI-ASL,FARID BEHBOODI-SADABAD,SAEID RAHIMI-RAZIN,HOSSEIN ROGHANI-MAMAQANI,MAHMOUD HEMMATI 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2012 NANO Vol.7 No.1

The effect of carbon nanotubes on the kinetics of free radical polymerization of methyl methacrylate (MMA) was investigated. To do this, pristine, acid treated, alcoholic and methacrylate-modified carbon nanotubes with different loadings were used and Conversion, molecular weight and polydispersity index (PDI) of all samples were monitored during polymerization. The results show that carbon nanotubes induce an induction time to polymerization system which is independent of modification system while decrease in monomer conversion can be improved by developing organic moieties on surface. Molecular weight and polydispersity index for free and attached-on-surface chains were studied separately and different kinetics behaviors were observed for them. Molecular weight of free chains was increased by adding carbon nanotubes while more modified nanotubes resulted in much increased molecular weight. On the other hand, more system stability of more modified nanotubes, which was tested using UV-Visible spectra, resulted in higher molecular weights. Adding more nanotubes in the case of MMA-modified nanotubes caused to determine an optimum loading value to reach maximum molecular weight of free chains which was ascribed to system stability according to UV-Visible results. In this optimum loading value, free chains had minimum PDI value. However, increasing carbon nanotubes content led to decreased molecular weight of attached chains while PDI values increased because of shielding effect as physical phenomenon.

Correlation of Microvessel Density with Nuclear Pleomorphism, Mitotic Count and Vascular Invasion in Breast and Prostate Cancers at Preclinical and Clinical Levels

Muhammadnejad, Samad,Muhammadnejad, Ahad,Haddadi, Mahnaz,Oghabian, Mohammad-Ali,Mohagheghi, Mohammad-Ali,Tirgari, Farrokh,Sadeghi-Fazel, Fariba,Amanpour, Saeid Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1

Background: Tumor angiogenesis correlates with recurrence and appears to be a prognostic factor for both breast and prostate cancers. In the present study, we aimed to investigate the correlation of microvessel density (MVD), a measure of angiogenesis, with nuclear pleomorphism, mitotic count, and vascular invasion in breast and prostate cancers at preclinical and clinical levels. Methods: Samples from xenograft tumors of luminal B breast cancer and prostate adenocarcinoma, established by BT-474 and PC-3 cell lines, respectively, and commensurate human paraffin-embedded blocks were obtained. To determine MVD, specimens were immunostained for CD-34. Nuclear pleomorphism, mitotic count, and vascular invasion were determined using hematoxylin and eosin (H&E)-stained slides. Results: MVD showed significant correlations with nuclear pleomorphism (r=0.68, P=0.03) and vascular invasion (r=0.77, P=0.009) in breast cancer. In prostate cancer, MVD was significantly correlated with nuclear pleomorphism (r=0.75, P=0.013) and mitotic count (r=0.75, P=0.012). In the breast cancer xenograft model, a significant correlation was observed between MVD and vascular invasion (r=0.87, P=0.011). In the prostate cancer xenograft model, MVD was significantly correlated with all three parameters (nuclear pleomorphism, r=0.95, P=0.001; mitotic count, r=0.91, P=0.001; and vascular invasion, r=0.79, P=0.017; respectively). Conclusions: Our results demonstrate that MVD is correlated with nuclear pleomorphism, mitotic count, and vascular invasion at both preclinical and clinical levels. This study therefore supports the predictive value of MVD in breast and prostate cancers.

INVESTIGATING THE EFFECT OF MCM-41 NANOPARTICLES ON THE KINETICS OF ATOM TRANSFER RADICAL POLYMERIZATION OF STYRENE

ABBAS ASFADEH,VAHID HADDADI-ASL,MEHDI SALAMI-KALAJAHI,MOHAMMADREZA SARSABILI,HOSSEIN ROGHANI-MAMAQANI 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2013 NANO Vol.8 No.2

Effect of pristine and modified MCM-41 on the kinetics of styrene atom transfer radical polymerization (ATRP) was studied using a double bound containing modifier at 110°C. Conversion, molecular weight and PDI were obtained during the polymerization reactions to study the polymerization kinetics. Addition of the both types of MCM-41 has resulted in inconsiderable variations on the kinetics of polymerization. A similar trend is observed for the molecular weight of the free chains; however, increasing MCM-41 content results in higher PDI values. Also, surface modification of MCM-41 results in lower polymerization rates. In the case of grafted chains, molecular weight and PDI values increase by increasing MCM-41 content.