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- 저자 : HAMANH TUAN (검색결과 4 건)
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HAMANH TUAN,Srijan Shrestha,Thu Huong Tran,Jeong Ah Kim,Mi Hee Woo,Jae Sue Choi,Byung Sun Min 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.9
Among the 2-arylbenzofuran derivatives isolatedfrom Morus alba, the farnesylated 2-arylbenzofuranis a rarer constituent. The derivative has been reported toexert anti-obesity effect; however, its inhibitory effect onprotein tyrosine phosphatase 1B (PTP1B) has not beeninvestigated. In the previous study, the presence of thefarnesyl group in the structure of 2-arylbenzofurans wasfound to have positive influences on their pancreatic lipaseinhibitory activity. In the present study, we have confirmedthe authenticity of the notation based on the PTP1B inhibitoryactivity of farnesylated 2-arylbenzofurans. Specifically,two farnesylated 2-arylbenzofurans [morusalfurans B(2) and C (3)] showed strong inhibitory effects on PTP1Bwith IC50values of 8.92 and 7.26 μM, respectively, whichwas significantly higher than that of the positive controls[sodium orthovanadate (IC50 = 15.10 μM) and ursolic acid (IC50 = 11.34 μM)]. Besides, two 2-arylbenzofurans[morusalfurans A (1) and F (6)], one flavonoid [morusalnolB (9)], and one geranylated stilbene [morusibene A (11)]exhibited PTP1B inhibition with IC50values ranging from11.02 to 26.56 μM. Kinetic studies revealed compounds 2, 3,6, and 11 as mixed type PTP1B inhibitors, while 1 and 9 areknown as noncompetitive. Molecular docking simulationsdemonstrated that these active compounds can bind withthe respective catalytic or/and allosteric sites of PTP1B withnegative binding energies and the results are in accordancewith that of the kinetic studies. To the best of our knowledge,this is the first time, the PTP1B inhibitory activityof eleven compounds (1–11), as well as the mechanism ofaction underlying the effects on PTP1B enzyme of the activecompounds, were investigated. In vitro and in silico resultssuggest that the farnesylated 2-arylbenzofurans from M. albamay potentially be utilized as an effective treatment therapyfor type 2 diabetes mellitus and its associated complications.
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Phytochemical and pharmacological properties of Myristica fragrans Houtt.: an updated review
HAMANH TUAN,Ngoc Khanh Vu,Thu Huong Tran,Jeong Ah Kim,Mi Hee Woo,Byung Sun Min 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.11
Myristica fragrans Houtt. (Myristicaceae), anaromatic evergreen tree, is well known as a commercialsource of mace (aril) and nutmeg (seed), which have longbeen widely used as spices in the culinary field. In addition,various parts of M. fragrans have been used in folk medicinefor treating several diseases. Since its extensive uses inthe culinary sector and folk medicine, M. fragrans has longattracted a great deal of attention from pharmacologists andchemists. Numerous studies have indicated that M. fragranscontains diverse phytochemicals such as lignans, neolignans,diphenylalkanes, phenylpropanoids, and terpenoids, whichexhibit many of pharmacological activities. Among them,macelignan (1), meso-dihydroguaiaretic acid (2), myristicin(111), and malabaricone C (Mal C, 104) are the most activecompounds. The aim of this review is to comprehensivelysummarize the phytochemical and pharmacological propertiesof M. fragrans that have reported to date.
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Yeon Woo Jung,Bo Mi Lee,HAMANH TUAN,Manh Hung Tran,Jeong Ah Kim,Suhyun Lee,Jeong-Hyung Lee,Mi Hee Woo,ByungSun Min 대한약학회 2019 Archives of Pharmacal Research Vol.42 No.4
As part of our ongoing program to develop anti-inflammatory agents, an extract derived from Saururus chinensis collected in Korea was found to inhibit nitric oxide (NO) production in RAW264.7 cells. Bioassay-guided fractionation led to the isolation two new (1 and 2) and six known dineolignans (3–8). To the best of our knowledge, manassatin B1 (3) was isolated from S. chinensis for the first time. All structures were elucidated using extensive spectroscopic analysis. Of these compounds, 2 and 8 inhibited lipopolysaccharide (LPS)-induced production of NO and showed IC50 values of 5.80 and 1.52 µM, respectively. LPS-induced expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) was also significantly suppressed by the administration of 2 and 8. In addition, these lignans induced the expression of heme oxygenase-1 (HO-1) in a concentration-dependent manner. Nuclear translocation of nuclear-E2-related factor 2 (Nrf2), a key regulator of HO-1 protein expression, was also induced in RAW264.7 cells treated with 2 and 8. These findings suggested that these lignans exerted anti-inflammatory effects in RAW264.7 cells through modulation of the Nrf2/HO-1 pathway and that they were potential HO-1 inducers for preventing or treating inflammation.
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Anti-inflammatory and Immunosuppressive Effects of Panax notoginseng
Thao Quyen Cao,한재혁,이현수,HAMANH TUAN,우미희,민병선 한국생약학회 2019 Natural Product Sciences Vol.25 No.4
Here, we designed to examine the anti-inflammatory effects on RAW264.7 cells and the immunosuppressive effects by evaluating interleukin-2 (IL-2) production in Jurkat T cells using a MeOH extract of Panax notoginseng roots. The results showed that the MeOH extract inhibited the synthesis of nitric oxide (NO) in a dose-dependent manner (IC50 value of 7.08 µg/mL) and displayed effects on T cell activation at a concentration of 400 µg/mL. In efforts to identify the potent compounds, bioactivity-guided fractionation of the MeOH extract and chemical investigation of its active CH2Cl2-, EtOAc-, and butanol- soluble fractions led to the successful isolation and identification of eleven compounds, including two polyacetylenes (1, 2), a steroid saponin (3), seven dammarane-type ginsenosides (4 – 10), and an oleanane-type ginsenoside (11). Among them, compound 11 was isolated from this plant for the first time. Compound 2 exhibited potent inhibitory effects on NO synthesis and an immunosuppressive effect with IC50 values of 2.28 and 65.57 µM, respectively.
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