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Racking shear resistance of steel frames with corner connected precast concrete infill panels
J.C.D. Hoenderkamp,H.H. Snijder,H. Hofmeyer 국제구조공학회 2015 Steel and Composite Structures, An International J Vol.19 No.6
When precast concrete infill panels are connected to steel frames at discrete locations, interaction at the structural interface is neither complete nor absent. The contribution of precast concrete infill panels to the lateral stiffness and strength of steel frames can be significant depending on the quality, quantity and location of the discrete interface connections. This paper presents preliminary experimental and finite element results of an investigation into the composite behaviour of a square steel frame with a precast concrete infill panel subject to lateral loading. The panel is connected at the corners to the ends of the top and bottom beams. The Frame-to-Panel-Connection, FPC4 between steel beam and concrete panel consists of two parts. A T-section with five achor bars welded to the top of the flange is cast in at the panel corner at a forty five degree angle. The triangularly shaped web of the T-section is reinforced against local buckling with a stiffener plate. The second part consists of a triangular gusset plate which is welded to the beam flange. Two bolts acting in shear connect the gusset plate to the web of the T-section. This way the connection can act in tension or compression. Experimental pull-out tests on individual connections allowed their load deflection characteristics to be established. A full scale experiment was performed on a one-storey one-bay 3 by 3 m infilled frame structure which was horizontally loaded at the top. With the characteristics of the frame-to-panel connections obtained from the experiments on individual connections, finite element analyses were performed on the infilled frame structures taking geometric and material non-linear behaviour of the structural components into account. The finite element model yields reasonably accurate results. This allows the model to be used for further parametric studies.
P.A. Teeuwen,C.S. Kleinman,H.H. Snijder,H. Hofmeyer 국제구조공학회 2010 Steel and Composite Structures, An International J Vol.10 No.1
As an alternative for conventional structures for tall buildings, a hybrid lateral load resisting structure has been designed, enabling the assembly of tall buildings directly from a truck. It consists of steel frames with discretely connected precast concrete infill panels provided with window openings. Besides the stiffening and strengthening effect of the infill panels on the frame structure, economical benefits may be derived from saving costs on materials and labour, and from reducing construction time. In order to develop design rules for this type of structure, the hybrid infilled frame has recently been subjected to experimental and numerical analyses. Ten full-scale tests were performed on one-storey, one-bay, 3 by 3 m infilled frame structures, having different window opening geometries. Subsequently, the response of the full-scale experiments was simulated with the finite element program DIANA. The finite element simulations were performed taking into account non-linear material characteristics and geometrical non-linearity. The experiments show that discretely connected precast concrete panels provided with a window opening, can significantly improve the performance of steel frames. A comparison between the full-scale experiments and simulations shows that the finite element models enable simulating the elastic and plastic behaviour of the hybrid infilled frame.
P.A. Teeuwen,C.S. Kleinman,H.H. Snijder,H. Hofmeyer 국제구조공학회 2006 Steel and Composite Structures, An International J Vol.6 No.1
As an alternative for conventional structures for tall buildings, a hybrid lateral load resisting structure has been designed, enabling the assembly of tall buildings directly from a truck. It consists of steel frames with discretely connected precast concrete infill panels provided with window openings. Besides the stiffening and strengthening effect of the infill panels on the frame structure, economical benefits may be derived from saving costs on materials and labour, and from reducing construction time. In order to develop design rules for this type of structure, the hybrid infilled frame has recently been subjected to experimental and numerical analyses. Ten full-scale tests were performed on one-storey, one-bay, 3 by 3 m infilled frame structures, having different window opening geometries. Subsequently, the response of the full-scale experiments was simulated with the finite element program DIANA. The finite element simulations were performed taking into account non-linear material characteristics and geometrical non-linearity. The experiments show that discretely connected precast concrete panels provided with a window opening, can significantly improve the performance of steel frames. A comparison between the full-scale experiments and simulations shows that the finite element models enable simulating the elastic and plastic behaviour of the hybrid infilled frame.
Vaccarella, S.,Herrero, R.,Snijders, P. J F,Dai, M.,Thomas, J. O,Hieu, N. T.,Ferreccio, C.,Matos, E.,Posso, H.,de Sanjose, S.,Shin, H. R.,Sukvirach, S.,Lazcano-Ponce, E.,Munoz, N.,Meijer, C. J L M,Fra Oxford University Press 2008 International journal of epidemiology Vol.37 No.3
<P>BACKGROUND: Smoking increases the risk of squamous-cell carcinoma of the cervix, but it is not clear whether smoking increases the risk of acquisition or persistence of human papillomavirus (HPV) infection. METHODS: Information on smoking was collected from 10 areas in four continents among population-based, age-stratified random samples of women aged 15 years or older. HPV testing was performed using PCR-based enzyme immunoassay. Unconditional logistic regression was used to estimate odds ratios (OR) and corresponding 95% confidence intervals (CI) of being HPV-positive by smoking habits, adjusted for age and lifetime number of sexual partners. RESULTS: Ten thousand five hundred and seventy-seven women (mean age 41.4 years) were included. Among current smokers, the risk of being HPV-positive increased with smoking intensity, after allowing for lifetime number of sexual partners: ORs for <5, 5-14 and >/=15 cigarettes per day were 1.21 (95% CI 0.95-1.54), 1.39 (95% CI 1.04-1.87) and 2.01 (95% CI 1.32-3.08), respectively, as compared with never-smokers. The risk among former smokers (OR = 0.95, 95% CI 0.73-1.23) was similar to that among never-smokers. Analyses stratified by lifetime number of sexual partners showed a significant trend in risk only for women with one lifetime sexual partner. CONCLUSIONS: Our study suggests that current, though not former, smoking is associated with an increased prevalence of HPV, after allowance for sexual covariates. Among current smokers, HPV prevalence increased with smoking intensity, but a clear dose-response relationship was exclusively seen among women who declared one lifetime sexual partner.</P>
KPC1-Mediated Ubiquitination and Proteasomal Processing of NF-κB1 p105 to p50 Restricts Tumor Growth
Kravtsova-Ivantsiv, Y.,Shomer, I.,Cohen-Kaplan, V.,Snijder, B.,Superti-Furga, G.,Gonen, H.,Sommer, T.,Ziv, T.,Admon, A.,Naroditsky, I.,Jbara, M.,Brik, A.,Pikarsky, E.,Kwon, Y.,Doweck, I.,Ciechanover, Cell Press ; MIT Press 2015 Cell Vol.161 No.2
NF-κB is a key transcriptional regulator involved in inflammation and cell proliferation, survival, and transformation. Several key steps in its activation are mediated by the ubiquitin (Ub) system. One uncharacterized step is limited proteasomal processing of the NF-κB1 precursor p105 to the p50 active subunit. Here, we identify KPC1 as the Ub ligase (E3) that binds to the ankyrin repeats domain of p105, ubiquitinates it, and mediates its processing both under basal conditions and following signaling. Overexpression of KPC1 inhibits tumor growth likely mediated via excessive generation of p50. Also, overabundance of p50 downregulates p65, suggesting that a p50-p50 homodimer may modulate transcription in place of the tumorigenic p50-p65. Transcript analysis reveals increased expression of genes associated with tumor-suppressive signals. Overall, KPC1 regulation of NF-κB1 processing appears to constitute an important balancing step among the stimulatory and inhibitory activities of the transcription factor in cell growth control.