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H M Rakib ul Hasan,Mijeong Noh 글로벌지식마케팅경영학회 2016 Global Marketing Conference Vol.2016 No.7
The concept of retail therapy which refers to “the phenomenon in which consumers buy things to make themselves feel better” (Kacen, 1998) has been used by the U.S. retail firms in marketing (Kang & Johnson, 2010). Previous studies found that retail therapy concept was associated to consumption behaviors including compulsive buying (Faber & O’Guinn, 1992; O’Guinn & Faber, 1989). Frost et al. (1998) found that compulsive hoarders show compulsive buying tendencies. O’Guinn and Faber (1989) found that compulsive buyers are more likely to confirm compulsivity as a personality trait with a low self-esteem. Lack of research into association of retail therapy to compulsive consumer behaviors motivated us to pursue this study which investigate relationships among retail therapy, compulsive buying and compulsive hoarding, and to examine the moderating effect of consumers’ personality traits on the relationship between retail therapy and compulsive hoarding. Our research questions are: (1) How retail therapy is related to compulsive buying and compulsive hoarding? and (2) Which personality traits moderate the relationship between retail therapy and compulsive hoarding? Based on the literature review, the following hypotheses were proposed. H1: Retail therapy is positively related to compulsive buying; H2: Compulsive buying is positively related to compulsive hoarding; H3: Retail therapy is positively related to compulsive hoarding & H4: Personality trait moderates the relationship between retail therapy and compulsive hoarding. The researchers used 12 items to measure retail therapy (Kang, 2009), 6 items to measure compulsive buying (Faber & O’Guinn, 1992), 9 items to measure compulsive hoarding (Frost, Sketekee, & Grisham, 2004) 8 items of Big Five Inventory (Rammstedt & John, 2007) and 15 item Narcissistic Personality Inventory (NPI) (Ames, Rose & Anderson, 2006) to measure personality trait based on 7‑point Likert scales (1 = strongly disagree, 7 = strongly agree). The online survey was conducted with college students enrolled at a major Midwestern University. A total of 354 undergraduate and graduate students’ responses were used to analyze data. A principal component factor analysis with varimax rotation was conducted to evaluate the measurement of each construct. The factor loadings were above of 0.60, indicating acceptable convergent validity. Reliabilities with Cronbach’s alphas for retail therapy,compulsive buying, compulsive hoarding and personality trait construct were 0.96, 0.81, 0.90 and 0.81 respectively, exceeding the suggested level of 0.70. Simple linear regression was performed to test hypotheses. The results revealed that F statistic (F(1, 352)=126.53, p =.000) was significant and regression coefficient was statistically significant. Therefore, H1 was supported and consistent with previous findings (Faber & O’Guinn, 1992). The regression coefficient for the path from compulsive buying to compulsive hoarding was statistically significant (F(1, 352)=77.15, p=.000). Therefore, H2 was supported and consistent with Frost et al. (1998)’s study. The retail therapy contributed significantly to the prediction of compulsive hoarding with the statistically significant regression results (F(1, 352)=20.28, p=.000), supporting H3. From the principle component analysis with varimax rotation, four factors were extracted from 23 personality trait measurement items which are labeled as “authority-leadership narcissism”, “self-esteem narcissism”, “positive disposition”, and “negative disposition”. All factor loadings were above 0.60 for their respective factors. Then, the researchers divided one single group into four personality trait groups, using these four factors. 4%, 27.1%, 53.7% & 15.3% participants represented “authority-leadership narcissism”, “self-esteem narcissism”, “positive disposition” & “negative disposition” group respectively. Simple regression analysis was performed to test H4. The regression coefficients for positive disposition group (F(1, 188)=13.19, p=.000) and negative disposition group (F(1, 52)=5.01, p≤.05) were statistically significant. H4 was partially supported. The results indicated that people from two groups characterized by positive/negative personality tend to engage in compulsive hoarding to alleviate their negative feelings or mood. Anyone with narcissistic personality with a high self-efficacy may not be engaged in compulsive hoarding even when a therapeutic treatment is made through shopping. They tend to purchase products for changing their moods, but their therapeutic behavior doesn’t lead to compulsive hoarding, which causes sufferings in the end. The low self-esteem has been presented with people being engaged in compulsive behaviors (Marlatt et al., 1988). These findings can help apparel marketers develop the strategies to upgrade their sellingenvironment entertaining so that their customers’ moods are repaired and customers feel satisfied through therapeutic shopping behavior. This study has a limitation that prevents us from generalizing the results to the young consumer population due to sample size to college students.
Kwon, J. H.,Kim, J. H.,Lee, D. h.,Cho, H.,Hwang, S. Y.,Yuk, S. S.,Erdene-Ochir, T. O.,Noh, J. Y.,Hong, W. T.,Jeong, J. H. Springer Science + Business Media 2016 BioChip Journal Vol.10 No.3
<P>Highly pathogenic avian influenza (HPAI) viruses cause economic losses in the poultry industry and pose a severe threat to human health. Rapid and accurate diagnostic methods are important because they can help prevent further spread of the virus and reduce the time required for eradication of the virus. We developed a low-density microarray for the rapid detection and identification of avian influenza virus subtypes H5, H7, and H9 and their pathotypes in a previous study. In the present study, we report the development of updated probe sets and evaluation of the diagnostic microarray using H5N8 clade 2.3.4.4 HPAI viruses including clinical samples, without the need for egg propagation. Cy3-labeled DNA targets were obtained by reverse transcription polymerase chain reaction using Cy3-labeled universal primers, and labeled amplicons were hybridized to the microarray. All positive samples from RT-PCR showed H5-specific and highly pathogenic pattern in the microarray, without purification of PCR products. Furthermore, it allowed for specific detection of the subtype and pathotype from low DNA concentration samples that did not allow direct sequence analysis. Therefore, this diagnostic microarray has enormous potential for the rapid subtyping and pathotyping from clinical samples without the need for culture.</P>
Park, J.K.,Lee, D.H.,Cho, C.H.,Yuk, S.S.,To, E.O.,Kwon, J.H.,Noh, J.Y.,Kim, B.Y.,Choi, S.W.,Shim, B.S.,Song, M.K.,Lee, J.B.,Park, S.Y.,Choi, I.S.,Song, C.S. Elsevier Scientific Pub. Co 2014 Veterinary microbiology Vol.169 No.3
Avian influenza virus (AIV) subtype H9N2 has been evolving rapidly and vaccine escape variants have been reported to cause circulation of infections and economic losses. In the present study, we developed and evaluated ectodomain of the AIV matrix 2 (M2e) protein as a supplementing antigen for oil-based inactivated H9N2 vaccine to increase resistance against vaccine escape variants. AIV H9N2 M2e antigen was expressed in Escherichia coli and supplemented to inactivated H9N2 oil emulsion vaccine. Specific pathogen-free chickens received a single injection of inactivated H9N2 oil emulsion vaccines with or without M2e supplementation. At three weeks post vaccination, hemagglutination inhibition tests and enzyme-linked immunosorbent assays were performed to determine serological immune responses. Challenge study using a vaccine escape H9N2 variant was performed to evaluate the efficacy of M2e supplementation. M2e antigen supplemented in oil emulsion vaccine was highly immunogenic, and a single M2e-supplemented vaccination reduced challenge virus replication and shedding more effectively than non-supplemented vaccination.
Lee, E.K.,Kim, S.Y.,Noh, K.W.,Joo, E.H.,Zhao, B.,Kieff, E.,Kang, M.S. Elsevier/North-Holland 2014 ANTIVIRAL RESEARCH Vol.104 No.-
The replication and persistence of extra chromosomal Epstein-Barr virus (EBV) episome in latently infected cells are primarily dependent on the binding of EBV-encoded nuclear antigen 1 (EBNA1) to the cognate EBV oriP element. In continuation of the previous study, herein we characterized EBNA1 small molecule inhibitors (H20, H31) and their underlying inhibitory mechanisms. In silico docking analyses predicted that H20 fits into a pocket in the EBNA1 DNA binding domain (DBD). However, H20 did not significantly affect EBNA1 binding to its cognate sequence. A limited structure-relationship study of H20 identified a hydrophobic compound H31, as an EBNA1 inhibitor. An in vitro EBNA1 EMSA and in vivo EGFP-EBNA1 confocal microscopy analysis showed that H31 inhibited EBNA1-dependent oriP sequence-specific DNA binding activity, but not sequence-nonspecific chromosomal association. Consistent with this, H31 repressed the EBNA1-dependent transcription, replication, and persistence of an EBV oriP plasmid. Furthermore, H31 induced progressive loss of EBV episome. In addition, H31 selectively retarded the growth of EBV-infected LCL or Burkitt's lymphoma cells. These data indicate that H31 inhibition of EBNA1-dependent DNA binding decreases transcription from and persistence of EBV episome in EBV-infected cells. These new compounds might be useful probes for dissecting EBNA1 functions in vitro and in vivo.
Kang, S.,Siddiqi, M. H.,Yoon, S. J.,Ahn, S.,Noh, H. Y.,Kumar, N. S.,Kim, Y. J.,Yang, D. C. Springer Science + Business Media 2016 In vitro cellular & developmental biology Animal Vol.52 No.9
<P>Ginsenosides have been used traditionally as an oriental medicine. However, the anti-osteoarthritic effect of ginsenoside compound K (hereafter referred to as CK) has not been reported. Therefore, in this study, the protective effects of CK were evaluated in silico and in vitro using H2O2-stimulated MC3T3-E1 cells by measuring the levels of proinflammatory cytokines responsible for articular cartilage degradation. In silico results demonstrated that, among the selected ginsenosides, CK is a non-toxic drug-like molecule with strong binding affinity for selected cytokine-activated kinase such as IkB alpha kinase (IKK). The molecular binding energy of CK with the active sites of IKK suggests anti-osteoarthritic functions. Cultured H2O2-stimulated MC3T3-E1 cells that were exposed to CK showed dramatically increased expression of osteoblast differentiation markers such as alkaline phosphatase (ALP) activity, type I collagen (Col-I) content, and mineralization. During aging, H2O2 also leads to the production of reactive oxygen species (ROS) and nitric oxide (NO), which play important roles in the development of osteoarthritis (OA). Therefore, the effect of CK on ROS and NO generation was also examined. Our results showed that CK dose-dependently inhibited H2O2-induced ROS and NO production in MC3T3-E1 cells. Moreover, qRT-PCR data showed that CK increased expression of osteogenic markers such as ALP and Col-I but decreased expression of inflammatory-related genes including IKK and interleukin 1 beta (IL-1 beta) in a dose-dependent manner in H2O2-stimulated MC3T3-E1 cells. The findings of this study suggest the use of CK as a novel protective and therapeutic agent in AO.</P>
Yuk, S.s.,Erdene-Ochir, T.O.,Kwon, J.H.,Noh, J.Y.,Hong, W.t.,Jeong, J.H.,Jeong, S.,Gwon, G.B.,Shin, J.i.,Sur, J.H.,Song, C.S. Butterworths ; Elsevier Science Ltd 2017 Vaccine Vol.35 No.9
Emerging clade 2.3.4.4 of the highly pathogenic avian influenza (HPAI) virus strain H5N8, which had been detected sporadically in domestic poultry in China, started to affect wild birds and poultry in South Korea in 2014. The virus was spread to Germany, Italy, the Netherlands, United Kingdom, and even United States by migratory birds. Here, we tested currently used commercial clade 2.3.2 H5 vaccines to evaluate mortality, clinical signs, virus shedding, and histological damage after experimental infection of chickens with the clade 2.3.4.4 HPAI H5N8 virus. Although the vaccination protected chickens from death, it failed to prevent chickens from shedding the virus and from tissue damage according to histological examination. These results suggest that the use of appropriate vaccines that match the currently epidemic HPAI virus is recommended, and continuous HPAI surveillance and testing of currently used commercial vaccines should be performed.