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Michiko Tsushima,Jun Liu,Wataru Hirao,Hiromi Yamazaki,Hirofumi Tomita,Ken Itoh 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.3
Nrf2 regulates redox homeostasis in cells bycoordinately regulating a range of antioxidant enzymes andproteins. An increase in oxidative stress is one of the hallmarksof aging, and Nrf2 protein levels and activity decreasewith aging. Decreased mitochondrial functions, such asdecreased ATP production, also occur with aging, leadingto the increased generation of reactive oxygen species (ROS)and oxidative stress. Thus, understanding the relationshipsbetween Nrf2 and the mitochondria is important for clarifyingthe regulatory mechanisms of aging. It is becomingclear that Nrf2 is activated in a tissue-specific manner inresponse to mitochondrial or NADPH oxidase-generatedROS. As the heart consists of postmitotic cells that utilizeATP produced mainly by mitochondrial oxidative phosphorylation,cardiomyocytes are equipped with highly sophisticatedmitochondrial quality control mechanisms. Consistentwith these findings, it has been reported that Nrf2 inthe heart is regulated via a specific translational mechanismand that Nrf2 activation confers cardioprotective effects invarious disease models. Thus, Nrf2 is a promising target foranti-aging strategies to combat age-related heart diseases,such as age-related cardiomyopathy.
Kanako Tsushima,Satoshi Ogasawara,Koji Orikawa,Masatsugu Takemoto,Kenji Koyama 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
This paper deals with electromagnetic interference radiated from air-conditioner piping that acts as an antenna and emits electromagnetic noise. The current distribution on the piping is measured by using a near-field magnetic probe, and the distribution mode is analyzed. The results show that the piping resonates at the frequencies where the piping length accords with λ/4, 3λ/4, and 5λ/4, and radiates electromagnetic noise as a monopole antenna. This radiation mechanism is confirmed by simulations using the CST EMC Studio electromagnetic field simulator.
Efficiency of Phototransduction Cascade in Carp Cones
Tachibanaki, Shuji,Tsushima, Sawae,Kawamura, Satoru Korean Society of Photoscience 2002 Journal of Photosciences Vol.9 No.2
In the vertebrate retina, rods mediate twilight vision and cones daylight vision. Rods have been purified easily from the retina, and thus the phototransduction mechanism in rods is now well documented. However, it has not been possible to purify cones in large quantities, and therefore, the knowledge on the mechanism in cones is limited. Here we report purification of carp (Cyprinus carpio) cones with a stepwise Percoll gradient. Using purified cells, we compared the phototransduction mechanism between rods and cones. The results showed that both transducin activation and phosphodiesterase activation are less effective, and visual pigment phosphorylation is faster in cones. These differences explain lower light-sensitivity and briefer photoresponse time course in cones.
Hybrid Capacitors Using Organic Electrolytes
Morimoto, T.,Che, Y.,Tsushima, M. The Korean Electrochemical Society 2003 한국전기화학회지 Vol.6 No.3
Electric double-layer capacitors based on charge storage at the interface between a high surface area activated carbon electrode and an electrolyte solution are characterized by their long cycle-life and high power density in comparison with batteries. However, energy density of electric double-layer capacitors obtained at present is about 6 Wh/kg at a power density of 500W/kg which is smaller as compared with that of batteries and limits the wide spread use of the capacitors. Therefore, a new capacitor that shows larger energy density than that of electric double-layer capacitors is proposed. The new capacitor is the hybrid capacitor consisting of activated carbon cathode, carbonaceous anode and an organic electrolyte. Maximum voltage applicable to the cell is over 4.2V that is larger than that of the electric double-layer capacitor. As a result, discharged energy density on the basis of stacked volume of electrode, current collector and separator is more than 18Wh/l at a power density of 500W/l.
Ichida, Miho,Kataoka, Akemi,Tsushima, Ruriko,Taguchi, Tetsuya Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Background: Low-dose oral contraceptives (OC) were approved by the Japanese Ministry of Health, Labor and Welfare in 1999, yet despite their contraceptive and non-contraceptive health benefits, only 5% of the target population use them. Fear of increased cancer risk, particularly breast cancer, is one reason for this. Due to low OC uptake and low screening participation, a paucity of data is available on the risk of OC use and breast cancer in Japanese women. The present study investigated OC use and breast cancer risk, as well as menstrual, reproductive and family factors. Materials and Methods: This was a clinic-based case-control study of women aged 20-69yrs who had undergone breast screening between January 2007 and December 2013 in central Tokyo. In all, 28.8% of the participants had experience with OC use. Cases were 155 women with a pathologically confirmed diagnosis of breast cancer. Controls were the remaining 12,333 women. Results: Increased age was a significant risk factor for breast cancer (p<0.001). A lower risk was found in premenopausal women presently taking OC compared to never users (OR 0.45; 95% CI 0.22-0.90) after adjusting for age, parity and breast feeding, and a family history of breast cancer. Conclusions: Increased age rather than OC use had a greater effect on breast cancer risk. This risk may be decreased in premenopausal women with OC use, but further long-term prospective studies are necessary.
Peptides from Bombyx Fibroin Counter D-Galactose-induced Hair Aging in Mice
Yamamoto, Kei-Ichiro,Tsushima, Masaaki,Yoshida, Atsushi,Karimazawa, Mayumi,Nagasuna, Osamu,Uchidate, Michimasa,Iwabuchi, Akira,Goryo, Masanobu,Yamashita, Tetsuro,Suzuk, Koichi Korean Society of Sericultural Science 2011 International Journal of Industrial Entomology Vol.23 No.2
Using proteases, we produced a peptide mixture from fibroin of the silkworm $Bombyx$ $mori$. Mice received D-galactose by subcutaneous injection for 8 weeks to accelerate aging, and then received the peptide mixture orally for 7 weeks. In the mice aged with D-galactose, the coefficient of friction of hair increased significantly up to 1.6-fold, but in the mice subsequently given the peptide mixture, it was normal. Scanning electron microscopy showed improved hair cuticles in the latter mice too. These results indicate that oral administration with peptides from $Bombyx$ fibroin counters the aging of hair cuticles.
Research Articles : Peptides from Bombyx Fibroin Counter D-Galactose-induced Hair Aging in Mice
( Kei Ichiro Yamamoto ),( Masaaki Tsushima ),( Atsushi Yoshida ),( Mayumi Karimazawa ),( Osamu Nagasuna ),( Michimasa Uchidate ),( Akira Iwabuchi ),( Masanobu Goryo ),( Tetsuro Yamashita ),( Koichi Su 한국잠사학회 2011 International Journal of Industrial Entomology Vol.23 No.2
Using proteases, we produced a peptide mixture from fibroin of the silkworm Bombyx mori. Mice received D-galactose by subcutaneous injection for 8 weeks to accelerate aging, and then received the peptide mixture orally for 7 weeks. In the mice aged with D-galactose, the coefficient of friction of hair increased significantly up to 1.6-fold, but in the mice subsequently given the peptide mixture, it was normal. Scanning electron microscopy showed improved hair cuticles in the latter mice too. These results indicate that oral administration with peptides from Bombyx fibroin counters the aging of hair cuticles.