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( Jia Cheng ),( Na Sun ),( Xin Zhao ),( Li Niu ),( Mei Qin Song ),( Yao Gui Sun ),( Jun Bing Jiang ),( Jian Hua Guo2 ),( Yuan Sheng Bai ),( Jun Ping He ),( Hong Quan Li ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.8
Seventeen compounds derived from traditional Chinese medicines (TCMs) were tested for their antiviral activity against porcine reproductive and respiratory syndrome virus (PRRSV) in vitro. Visualization with the cytopathologic effect (CPE) assay and the 3-(4, 5-dimethyithiazol- 2-yl)-2,5-diphenyltetrazolium bromide test were used to determine the 50% cytotoxic concentration (CC50) and 50% effective concentration (EC50) in cultured Marc-145 cells. Among the tested compounds, chlorogenic acid and scutellarin showed potential anti-PRRSV activity. The EC50 values were 270.8 ± 14.6 μg/ml and 28.21 ± 26.0 μg/ml and the selectivity indexes were >5.54 and 35.5, respectively. The time-of-addition and virucidal assay indicated that the anti-PRRSV activity of the two compounds could be due to their inhibiting the early stage of virus replication and/or inactivating the virus directly. The inhibition of the virus attachment was not observed in the adsorption inhibition assay. The inhibition ratios of chlorogenic acid and scutellarin were, respectively, 90.8% and 61.1% at the maximum non-cytotoxic concentrations. The results have provided a basis for further exploration of their antiviral properties and mechanisms in vivo. We believe that the chlorogenic acid and scutellarin have a great potential to be developed as new anti-PRRSV drugs for clinical application.
Studies on Residue Stress and Deformation Behavior of GCr15 Subjected to Whirlwind Milling
Qin Guo,Youfeng Xu,Mulan Wang,Wenliang Yang,Yuliln Wang 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.8
Whirlwind milling is gaining extensive application for processing a large screw. Due to its specific forming principle, the profile of residual stresses and the deformation behavior would been given significant emphasis. Under conditions of large cutting depth (0.06–0.12 mm), the effect of cutting parameters on three characteristic parameters of the residual stress, such as surface residual stress, maximum residual stress and residual stress extreme value, was always different from that under small cutting depth (6–10 μm). Comparing to the right arc of the screw, the plastic deformation in the left arc is more obvious and far-reaching. The most extensive deformation region caused by WM cutting force was found for the topmost surface. As cutting speed increased, the nanohardness variation reflected the decreasing plastic deformation. Therefore, the research on physical change by WM is instructive for extending the fatigue life of the screw.
( Yan-qin Long ),( Wen-li Xu ),( Lu-xiu Li ),( Hui-qin He ),( Jing-jie Wang ),( Guo-dong Shan ),( Ning Dai ),( Hong-tan Chen ) 대한소화기기능성질환·운동학회 2024 Journal of Neurogastroenterology and Motility (JNM Vol.30 No.2
Background/Aims Functional dyspepsia (FD) overlapping with other gastrointestinal disorders are quite common. The characteristics of FD overlap in Chinese population with latest Rome IV criteria were unclear. This large-scale outpatient-based study assessed the characteristics of FD overlap in South China. Methods Consecutive FD patients visited the Gastroenterology Clinic at 2 tertiary medical centers in Hangzhou, China who fulfilled the Rome IV criteria were enrolled. Complete questionnaires related to the gastrointestinal symptoms (Rome IV criteria), Reflux Disease Questionnaire, anxiety and depression, quality of sleep and life, and demographic information were collected. Results Among the total of 3281 FD patients, 50.69% overlapped with gastroesophageal reflux disease, 21.46% overlapped with irritable bowel syndrome, 6.03% overlapped with functional constipation. FD overlap had higher proportion of single/divorced/widowed rate, high education level, being employed, drinking, night shift, unhealthy dietary habit than FD only (P < 0.05). They had higher frequency of consultation and economic burden, as well as lower scores in quality of life (P < 0.001). Multivariate logistic regression showed that increasing age, female, low body mass index, history of gastroenteritis, anxiety, depression, and poor sleep quality were independent risk factors for FD overlap. Conclusions FD overlap was quite common in China with high economic burden and poor quality of life, FD patients with history of gastroenteritis, anxiety, depression, and poor sleep quality were more likely to have overlap disorders. Awareness of the physical and psychosocial stressors in overlapping condition would help optimize the management of FD overlap in clinical practice. (J Neurogastroenterol Motil 2024;30:184-193)
Zhang, Zhi-Guo,Li, Gang,Feng, Da-Yun,Zhang, Jian,Zhang, Jing,Qin, Huai-Zhou,Ma, Lian-Ting,Gao, Guo-Dong,Wu, Lin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1
Several recent studies have showed that the n-myc downstream regulated gene 2 (NDRG2) is a new tumor suppressor gene, and that it plays an important role in tumor suppression in several cancers or cancer cell lines. However, few studies focused on its function in neuroblastoma cells. In the present investigation, we demonstrated that NDRG2 overexpression inhibited their proliferation. Using a cDNA microarray, we found that overexpression of NDRG2 inhibited the expression of cysteine-rich protein 61 (CYR61), a proliferation related gene. From our research, CYR61 may partially hinder NDRG2-mediated inhibition of cell proliferation. Overexpression of NDRG2 resulted in accumulation of cells in the G1 phase, which was accompanied by upregulation of p21 and p27 and downregulation of CDK4 and cyclin D1. Taken together, these data indicate that NDRG2 inhibits the proliferation of neuroblastoma cells partially through suppression of CYR61. Our findings offer novel insights into the physiological roles of NDRG2 in neuroblastoma cell proliferation, and NDRG2 may prove to be effective candidate for the treatment of children with neuroblastoma.
Yang, Nian-Qin,Zhang, Jian,Tang, Qun-Ye,Guo, Jian-Ming,Wang, Guo-Min Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15
To investigate the role of miR-1297 and the tumor suppressor gene PTEN in cell proliferation of testicular germ cell tumors (TGCT). MTT assays were used to test the effect of miR-1297 on proliferation of the NCCIT testicular germ cell tumor cell line. In NCCIT cells, the expression of PTEN was assessed by Western blotting further. In order to confirm target association between miR-1297 and 3'-UTR of PTEN, a luciferase reporter activity assay was employed. Moreover, roles of PTEN in proliferation of NCCIT cells were evaluated by transfection of PTEN siRNA. Proliferation of NCCIT cells was promoted by miR-1297 in a concentration-dependent manner. In addition, miR-1297 could bind to the 3'-UTR of PTEN based on luciferase reporter activity assay, and reduced expression of PTEN at protein level was found. Proliferation of NCCIT cells was significantly enhanced after knockdown of PTEN by siRNA. miR-1297 as a potential oncogene could induce cell proliferation by targeting PTEN in NCCIT cells.
Iterative Learning Control for a Class of Mixed Hyperbolic-parabolic Distributed Parameter Systems
Qin Fu,Wei-Guo Gu,Pan-Pan Gu,Jian-Rong Wu 제어·로봇·시스템학회 2016 International Journal of Control, Automation, and Vol.14 No.6
This paper deals with the problem of iterative learning control algorithm for a class of mixed distributedparameter systems. Here, the considered distributed parameter systems are composed of mixed hyperbolicparabolicpartial differential equations. The domain of the system is divided into two parts in which the system ishyperbolic and parabolic, respectively, with transmission conditions at the interface. According to the characteristicsof the systems, iterative learning control laws are proposed for such mixed hyperbolic-parabolic distributedparameter systems based on P-type learning scheme. Using the contraction mapping method, it is shown that thescheme can guarantee the output tracking errors on L2 space converge along the iteration axis. A simulation exampleillustrates the effectiveness of the proposed method.
Qin, Ai-Qiu,Liang, Zhong-Guo,Ye, Jia-Xiang,Li, Jing,Wang, Jian-Li,Chen, Chang-Xian,Song, Hong-Lin Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.8
Background: Whether concurrent chemotherapy treatment is superior to radiotherapy alone as an adjuvant regimen for postoperative cervical carcinoma with risk factors remains controversial. Materials and Methods: A literature search strategy examined Pubmed, Embase, the Cochrane Library, the China National Knowledge Internet Web, the Chinese Biomedical Database and the Wanfang Database. Article reference lists and scientific meeting abstracts were also screened. Controlled trials comparing concurrent chemoradiotherapy versus radiotherapy alone in postoperative cervical cancer were included. The methodological quality of non-randomized controlled trials was evaluated using the Newcastle-Ottawa Scale. Randomized controlled studies were evaluated with the Cochrane handbook. A meta-analysis was performed with RevMan 5.3. Results: A total of 1,073 patients from 11 clinical trials were analysed, with 582 patients in the concurrent chemoradiotherapy group and 491 patients in the radiotherapy group. Hazard ratios (HR) of 0.47 (95% CI 0.31-0.72) and 0.50 (95% CI 0.35-0.72) were observed for overall survival and progression-free survival, indicating a benefit from the additional use of concurrent chemotherapy. Subgroup analyses demonstrated that cervical cancer with high risk factors significantly benefitted from concurrent chemotherapy when examining overall survival (HR 0.44, 95% CI 0.28-0.67) and progression-free survival (HR 0.48, 95% CI 0.33-0.70), but patients with intermediate risk factors showed no benefit from concurrent chemotherapy in overall survival (HR 1.72, 95% CI 0.28-10.41) and progression-free survival (HR 1.09, 95% CI 0.19-6.14). No significant differences were observed for grade 3-4 anaemia (risk ratio (RR) 3.87, 95% CI 0.69-21.84), grade 3-4 thrombocytopenia (RR 3.04, 95% CI 0.88-10.58), grade 3-4 vomiting or nausea (RR 1.71, 95% CI 0.27-10.96), or grade 3-4 diarrhoea (RR 1.40, 95% CI 0.69-2.83). Significant differences were observed for grade 3-4 neutropenia in favour of the radiotherapy group (RR 7.23, 95% CI 3.94-13.26). Conclusions: In conclusion, concurrent chemoradiotherapy improves survival in postoperative cervical cancer with high risk factors but not in those with intermediate risk factors.
Agile Networking in Smart Grids
Qin, Zhenquan,Zhang, Jianing,Shi, Liang,Wang, Lei,Shu, Lei,Guo, Yuquan The Institute of Electronics and Information Engin 2012 IEIE Transactions on Smart Processing & Computing Vol.1 No.1
Recently, the smart grid (SG) has been introduced to solve the serious network issues caused by the increasing electrical demand and the complex nonlinear nature of the electric power distribution network. The SG, regarded as the next generation power grid, can transmit power in more efficient ways by building an automatic and distributed energy delivery network. In this paper, we first assess how various existing networking technologies, such as IEEE 802.11 (WiFi) and IEEE 802.15.4 (ZigBee), meet the requirements of the SG communication protocols. Specifically, we classify the existing network protocols into three categories: WSN-based networking, WiFi-based networking, and wireline-based networking. We then survey the security issues regarding the SG. Finally, we propose an agile SG networking architecture and show the effectiveness of different adopted networking technologies and, as a result, present a candidate solution to implement agile networking in SGs.