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RISS 인기검색어
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- 저자 : Goldar, Samira (검색결과 3 건)
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Molecular Mechanisms of Apoptosis and Roles in Cancer Development and Treatment
Goldar, Samira,Khaniani, Mahmoud Shekari,Derakhshan, Sima Mansoori,Baradaran, Behzad Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.6
Programmed cell death (PCD) or apoptosis is a mechanism which is crucial for all multicellular organisms to control cell proliferation and maintain tissue homeostasis as well as eliminate harmful or unnecessary cells from an organism. Defects in the physiological mechanisms of apoptosis may contribute to different human diseases like cancer. Identification of the mechanisms of apoptosis and its effector proteins as well as the genes responsible for apoptosis has provided a new opportunity to discover and develop novel agents that can increase the sensitivity of cancer cells to undergo apoptosis or reset their apoptotic threshold. These novel targeted therapies include those targeting anti-apoptotic Bcl-2 family members, p53, the extrinsic pathway, FLICE-inhibitory protein (c-FLIP), inhibitor of apoptosis (IAP) proteins, and the caspases. In recent years a number of these novel agents have been assessed in preclinical and clinical trials. In this review, we introduce some of the key regulatory molecules that control the apoptotic pathways, extrinsic and intrinsic death receptors, discuss how defects in apoptotic pathways contribute to cancer, and list several agents being developed to target apoptosis.
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Protective effect of Basella alba leaf against diabetic nephropathy in rats
Kumari Reshma,Goldar Waquar Ahmed,Mondal Subhodeep,Patra Susmita,Bhattacharya Sanjib,Haldar Pallab Kanti 경희대학교 융합한의과학연구소 2021 Oriental Pharmacy and Experimental Medicine Vol.21 No.1
Chronic hyperglycemic condition leads to development of diabetic nephropathy (DN). Basella alba is an important edible vegetable in India. Present study was conducted to inquire the effects of methanol extract from Basella alba leaf (MEBA) against diabetic nephropathy in rats. A single intraperitoneal injection of streptozotocin (55 mg/kg) was given to Wistar albino rats to induce diabetes. After 4 weeks of diabetes induction, the rats were divided into normal control group, disease DN group, MEBA treatment groups (200 and 400 mg/kg), metformin treatment group (150 mg/kg) and the treatment was continued for next 3 weeks. In MEBA treated groups there were marked improvements in blood glucose, ALP, ALT, total pro-tein, serum lipid profile such as total cholesterol, triglyceride, HDL levels and renal functions such as urine volume, urinary protein excretion, serum creatinine, blood urea nitrogen, creatinine clearance as compared to non-treated DN group. There was significant rise in malonaldehyde level, and decline in acivites of superoxide dismutase and reduced Glutathione (GSH) of kidney in diabetic rats as compared to normal control group rats. The MEBA treated groups showed dose dependent resto-ration of altered oxidative stress parameters. Moreover, from renal histopathology it was evident that the abnormal thickening of Glomerular basement membrane in kidney of diabetic rats were improved in MEBA treated rats. From the present study it can be concluded that, Basella alba leaf has marked protective effect against diabetic nephropathy and proteinuria in rats.
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Commercial Presence in the Hospital Sector under GATS - A Case Study of India
Indrani Gupta,Bishwanath Goldar 서울대학교 국제학연구소 2004 Journal of International and Area Studies Vol.11 No.2
The General Agreement on Trade in Services (GATS) is the first multilateral agreement under the World Trade Organisation (WTO) relating to trade in services. India is a member of WTO and a signatory to GATS. India is also the only country in the South-East Asia Region which has in its schedule of specific commitments included Hospital Services. This paper looks closely at the implications of GATS for India under the mode of supply called commercial presence. Specifically, this research attempts to understand whether foreign investment in the hospital sector is going to be consistent with the health sector goals of the country, in terms of access, availability and affordability of quality health care.
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