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- 저자 : George Uchenna Eleje (검색결과 2 건)
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Association between serum vitamin D status and uterine leiomyomas: a case-control study
Chukwuemeka Chukwubuikem Okoro,Okechukwu Christian Ikpeze,George Uchenna Eleje,Gerald Okanandu Udigwe,Chukwuemeka Okwudili Ezeama,Joseph Odirichukwu Ugboaja,Chukwunonso Isaiah Enechukwu,Osita Samuel U 대한산부인과학회 2024 Obstetrics & Gynecology Science Vol.67 No.1
Objective Uterine leiomyoma is a common gynecological condition that negatively affects women’s quality of life. Vitamin D plays an important role in tumor development and progression. However, clinical studies comparing serum vitamin D levels between women with and without uterine leiomyomas are limited and inconclusive. This study aimed to compare serum vitamin D levels in women with and without uterine leiomyomas. Methods This hospital-based case-control study included 150 women who visited a gynecological clinic. The cases included 75 women with uterine leiomyoma, whereas the controls included 75 age-and parity-matched participants without uterine leiomyoma. Serum vitamin D levels were measured in each participant and volumes of the uterine leiomyomas were determined using the water displacement method following myomectomy. The statistical significance was inferred at P<0.05. Results The mean serum vitamin D level was 15.26±4.96 ng/mL and 22.45±6.93 ng/mL for the case and control groups, respectively. The difference was statistically significant (t-value -7.302 and P<0.001). Within the fibroid group, nine (12.0%), 49 (65.33%), and 17 (22.67%) participants had vitamin D deficiency, insufficiency, and sufficiency, respectively; and in the control group, two (2.67%), 24 (45.33%), and 39 (52.0%) participants had vitamin D deficiency, insufficiency, and sufficiency, respectively. There was significant negative correlation between the fibroid volume and the serum vitamin D level (r=-0.591, P<0.001). Conclusion Women with uterine leiomyoma had lower vitamin D levels than women in the control group. Lower vitamin D levels were associated with larger fibroid masses. Therefore, vitamin D supplementation may reduce fibroid growth and development.
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Chukwunonso Isaiah Enechukwu,Anaelechi Jude Onuegbu,Madu Japheth Olisekodiaka,George Uchenna Eleje,Joseph Ifeanyichukwu Ikechebelu,Joseph Odirichukwu Ugboaja,Ubuo Kalu Amah,John Ekenedirichukwu Okwara 대한산부인과학회 2019 Obstetrics & Gynecology Science Vol.62 No.5
ObjectiveTo determine the activities of oxidative stress markers and lipid profiles of patients with polycystic ovary syndrome(PCOS) in Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria. MethodsThis was a nested case-control study consisting of 50 PCOS patients and 50 healthy women of the same age rangewithout any evidence of PCOS. The study measured the levels of malondialdehyde (MDA), activity of superoxidedismutase (SOD), glutathione peroxidase (GSH-Px), total antioxidant capacity (TAC); concentrations of total cholesterol(TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C), as well as high-density lipoprotein cholesterol(HDL-C) using standard spectrophotometric methods. Anthropometric indices were also assessed. P-values of <0.05were taken to be statistically significant. ResultsThere were significantly higher levels of MDA (P=0.002), lower activity of SOD (P<0.001), and lower TAC (P=0.001)in PCOS patients when compared with the controls. There were higher concentrations of TC (P=0.017) and LDL-CP=0.012) in PCOS patients than in controls. Significant differences were not observed between the 2 groups in termsof the activity of GSH-Px, as well as the concentrations of HDL-C and TG. The body mass index, waist circumference,and waist-hip ratio were all significantly higher in PCOS patients. ConclusionThis study revealed higher levels of MDA, as well as lower activity of SOD and TAC, among PCOS patients. Furthermore, there were higher levels of TC and LDL-C among the PCOS patients. Hence, monitoring these parametersmay improve the clinical management of PCOS.
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