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- 저자 : Gellatly, Kyle J. (검색결과 2 건)
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Gellatly, Kyle J.,Krim, Sarah,Palenchar, Daniel J.,Shepherd, Katie,Yoon, Kyong Sup,Rhodes, Christopher J.,Lee, Si Hyeock,Marshall Clark, J. Oxford University Press 2016 Journal of medical entomology Vol.53 No.3
<P>Pediculosis is a prevalent parasitic infestation of humans, which is increasing due, in part, to the selection of lice resistant to either the pyrethrins or pyrethroid insecticides by the knockdown resistance (<I>kdr</I>) mechanism. To determine the extent and magnitude of the <I>kdr</I>-type mutations responsible for this resistance, lice were collected from 138 collection sites in 48 U.S. states from 22 July 2013 to 11 May 2015 and analyzed by quantitative sequencing. Previously published data were used for comparisons of the changes in the frequency of the <I>kdr</I>-type mutations over time. Mean percent resistance allele frequency (mean % RAF) values across the three mutation loci were determined from each collection site. The overall mean % RAF (±SD) for all analyzed lice was 98.3 ± 10%. 132/138 sites (95.6%) had a mean % RAF of 100%, five sites (3.7%) had intermediate values, and only a single site had no mutations (0.0%). Forty-two states (88%) had a mean % RAF of 100%. The frequencies of <I>kdr</I>-type mutations did not differ regardless of the human population size that the lice were collected from, indicating a uniformly high level of resistant alleles. The loss of efficacy of the Nix formulation (Prestige Brand, Tarrytown, NY) from 1998 to 2013 was correlated to the increase in <I>kdr</I>-type mutations. These data provide a plausible reason for the decrease in the effectiveness of permethrin in the Nix formulation, which is the parallel increase of <I>kdr</I>-type mutations in lice over time.</P>
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Male Attitudes towards Infertility: Results from a Global Questionnaire
De Jonge Christopher J.,Gellatly Steven A.,Vazquez-Levin Mónica H.,Barratt Christopher L.R.,Rautakallio-Hokkanen Satu 대한남성과학회 2023 The World Journal of Men's Health Vol.41 No.1
Purpose: In general, men are less likely to seek health care than women. Infertility is a global disease that afflicts approxi-mately 15% of reproductive age couples and the male contributes to 40% of the diagnosable cause. Remarkably, no large or multi-national population data exist regarding men’s perceptions about their infertility. The purpose of this study was to advance our knowledge about the infertile male’s social experience regarding: (1) how they feel about their infertility, (2) what motivated them to seek health care, (3) how likely are they to talk with others about their infertility, (4) their awareness of male infertility support groups, and (5) what their primary source for information is regarding male infertility? Based on the results from this study, these simple questions now have clearer definition. Materials and Methods: An Institutional Review Board-approved, male-directed, anonymous questionnaire translated into 20 languages was made globally available through the Fertility Europe website (https://fertilityeurope.eu). Males (n=1,171) age 20–49 years were invited to complete the online survey after informed consent. Results: Most respondents were European (86%). Of European men, <15.8% were self-motivated to seek medical help. Fur-ther, their physician was not the primary source of information regarding their infertility. While most men (59%) viewed their infertility positively, a large majority were not very likely (73%) to talk about it. Most respondents indicated a lack of aware-ness or absence of male infertility support groups. Conclusions: These are the first multi-national population data revealing men’s feelings about their infertility, what motivates them to seek help and their awareness of resources for peer support and information. These findings also serve to highlight significant gaps that exist in the provision of male reproductive health care and in supportive resources for men suffering from infertility. We offer recommendations on how to address the problem(s).
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