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Review of Rehabilitation Robotics Applications
Gelderblom G.J.,Cremers G.,Soede M. 한국과학기술원 인간친화 복지 로봇 시스템 연구센터 2003 International Journal of Assistive Robotics and Me Vol.4 No.1
This paper describes a review study into the application of robotics and related technologies in the domain of rehabilitation. The study originated from the awareness that advanced technologies can be made to be of great benefit to people with severe functional limitations. However, the number of devices or systems that actually make it to the market seems limited. The review study was set out to describe and analyse the state-of-the-art. It resulted in a diverse collection of prototypes, projects and pilots. The material gathered in the review is too extensive to be presented in this paper and will be published on cd-rom.
Cremers G,Gelderblom G,J,van Lier J 한국과학기술원 인간친화 복지 로봇 시스템 연구센터 2003 International Journal of Assistive Robotics and Me Vol.4 No.1
This paper concerns the simulation of wheelchair use for the purpose of assessment and training. Two studies on this topic are described. The first study explores the possibilities for the development of a multimedia wheelchair simulator. Four goals for application are identified and a possible simulation configuration is presented. In the second study a prototype of a joystick simulator has been developed. This device is primarily designed for young infants commencing wheelchair driving and it features specific dynamic adjustment capabilities.
Cheng, Y.L.,Park, J.S.,Manzanero, S.,Choi, Y.,Baik, S.H.,Okun, E.,Gelderblom, M.,Fann, D.Y.W.,Magnus, T.,Launikonis, B.S.,Mattson, M.P.,Sobey, C.G.,Jo, D.G.,Arumugam, T.V. Blackwell Science ; Academic Press 2014 Neurobiology of disease Vol.62 No.-
Recent findings suggest that Notch-1 signaling contributes to neuronal death in ischemic stroke, but the underlying mechanisms are unknown. Hypoxia inducible factor-1α (HIF-1α), a global regulator of cellular responses to hypoxia, can interact with Notch and modulate its signaling during hypoxic stress. Here we show that Notch signaling interacts with the HIF-1α pathway in the process of ischemic neuronal death. We found that a chemical inhibitor of the Notch-activating enzyme, γ-secretase, and a HIF-1α inhibitor, protect cultured cortical neurons against ischemic stress, and combined inhibition of Notch-1 and HIF-1α further decreased neuronal death. HIF-1α and Notch intracellular domain (NICD) are co-expressed in the neuronal nucleus, and co-immunoprecipitated in cultured neurons and in brain tissue from mice subjected to focal ischemic stroke. Overexpression of NICD and HIF-1α in cultured human neural cells enhanced cell death under ischemia-like conditions, and a HIF-1α inhibitor rescued the cells. RNA interference-mediated depletion of endogenous NICD and HIF-1α also decreased cell death under ischemia-like conditions. Finally, mice treated with inhibitors of γ-secretase and HIF-1α exhibited improved outcome after focal ischemic stroke, with combined treatment being superior to individual treatments. Additional findings suggest that the NICD and HIF-1α collaborate to engage pro-inflammatory and apoptotic signaling pathways in stroke.