RISS 검색 - 국내학술지논문

무료
기관 내 무료
유료

내보내기
내책장담기
한글로보기

정확도순

내림차순

내림차순

10개씩 출력

1
Ultraviolet A Induces Immunosuppression, Protection or Memory Enhancement Depending on Dose, while Ultraviolet B is Immunosuppressive and Tolerogenic over a Large Dose Range

Halliday, Gary M.,Byrne, Scott N. Korean Society of Photoscience 2002 Journal of Photosciences Vol.9 No.2
- 원문보기
UVR-induced immunosuppression contributes to skin cancer. The aim was to construct accurate dose response curves for primary and secondary contact sensitivity for solar-simulated UVR (ssUVR; 290-400nm), UVA and UVB as the role of UVA in immunosuppression is controversial. We used a xenon arc source. The mice were immobilised, enabling accurate dosing. C57BL/6 mice were immunosuppressed at half the dose of ssUVR required to cause sunburn but not by higher doses (up to the sunburn dose). Thus, ssUVR causes systemic immunosuppression only over a narrow, low dose range. UVA caused suppression at low but not high doses whereas UVB induced immunosuppression at all doses tested. 8 weeks later the mice were resensitised to assess tolerance. Mice exposed to the minimum immunosuppressive dose of ssUVR prior to primary sensitisation were tolerant to re-sensitisation. However, at higher doses of ssUVR, these mice were protected from tolerance. Interestingly, while low doses of UV A caused immunosuppression, even lower doses enhanced the response to the second sensitisation. Higher doses of UVA had no affect. UVB induced tolerance in a dose related manner. Thus, ssUVR only induces immunosuppression and tolerance over a narrow dose range. Both UVA and UVB are immunosuppressive at this dose, while higher doses of UVA protect from the suppressive effects of UVB. Surprisingly very low doses of UVA enhanced memory development. Thus UVR has complex effects on the immune system depending on dose and spectrum.
2
Repeatability and Reliability Evaluation of a Wireless Head-band Sensor

Stephen Tiernan,David O'Sullivan,Gary Byrne 대한운동학회 2018 아시아 운동학 학술지 Vol.20 No.4
- 원문보기 2
  KCI
  
  스콜라
[OBJECTIVES] The objective of this study to examine the reliability and repeatability of the headband sensor in comparison with the gold standard 3 linear and 3 angular rate sensors placed at the center of gravity of the Hybrid III dummy head during drop tests. [METHODS] A SIM-G headband sensor was attached to a Hybrid III dummy head and neck which was equipped with a triaxial accelerometer and 3 angular rate sensors. Linear acceleration and angular rate was sampled at 10,000 Hz while the SIM-G headband was sampled at 1000 Hz and 800 Hz respectively. A drop test was developed to test between 20 to 140 g and consisted of a total of 400 impacts in four locations, left occipital, right occipital, frontal and rear impacts with 100 impacts per location. Multiple tests were performed at the same height to verify the reliability of the devices. SIM-G data and the reference sensors were compared for validity. [RESULTS] The reliability measured by Cronbach's alpha showed very high repeatability for the SIM-G (α = 0.97-0.99). However, the validity measurement, Pearson's Correlation coefficient (r), showed a weak to very strong relationship (r=0.2-0.9). [CONCLUSIONS] While using the SIM-G sensor to help monitor head impact, the weak to strong validity of the SIM-G sensor must be carefully considered by the clinicians or researchers as a serious limitation.
3
Modelling Spatially Regulated β-Catenin Dynamics and Invasion in Intestinal Crypts

Murray, Philip J.,Kang, Jun-Won,Mirams, Gary R.,Shin, Sung-Young,Byrne, Helen M.,Maini, Philip K.,Cho, Kwang-Hyun Elsevier 2010 Biophysical journal Vol.99 No.3
- 원문보기
AbstractExperimental data (e.g., genetic lineage and cell population studies) on intestinal crypts reveal that regulatory features of crypt behavior, such as control via morphogen gradients, are remarkably well conserved among numerous organisms (e.g., from mouse and rat to human) and throughout the different regions of the small and large intestines. In this article, we construct a partial differential equation model of a single colonic crypt that describes the spatial distribution of Wnt pathway proteins along the crypt axis. The novelty of our continuum model is that it is based upon assumptions that can be directly related to processes at the cellular and subcellular scales. We use the model to predict how the distributions of Wnt pathway proteins are affected by mutations. The model is then extended to investigate how mutant cell populations can invade neighboring crypts. The model simulations suggest that cell crowding caused by increased proliferation and decreased cell loss may be sufficient for a mutant cell population to colonize a neighboring healthy crypt.