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Urinary Biomarkers for the Noninvasive Detection of Gastric Cancer
Li, Dehong,Yan, Li,Lin, Fugui,Yuan, Xiumei,Yang, Xingwen,Yang, Xiaoyan,Wei, Lianhua,Yang, Yang,Lu, Yan The Korean Gastric Cancer Association 2022 Journal of gastric cancer Vol.22 No.-
Gastric cancer (GC) is associated with high morbidity and mortality rates. Thus, early diagnosis is important to improve disease prognosis. Endoscopic assessment represents the most reliable imaging method for GC diagnosis; however, it is semi-invasive and costly and heavily depends on the skills of the endoscopist, which limit its clinical applicability. Therefore, the search for new sensitive biomarkers for the early detection of GC using noninvasive sampling collection methods has attracted much attention among scientists. Urine is considered an ideal biofluid, as it is readily accessible, less complex, and relatively stable than plasma and serum. Over the years, substantial progress has been made in screening for potential urinary biomarkers for GC. This review explores the possible applications and limitations of urinary biomarkers in GC detection and diagnosis.
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Urinary Biomarkers for the Noninvasive Detection of Gastric Cancer
Li Dehong,Yan Li,Lin Fugui,Yuan Xiumei,Yang Xingwen,Yang Xiaoyan,Wei Lianhua,Yang Yang,Lu Yan 대한위암학회 2022 Journal of gastric cancer Vol.22 No.4
Gastric cancer (GC) is associated with high morbidity and mortality rates. Thus, early diagnosis is important to improve disease prognosis. Endoscopic assessment represents the most reliable imaging method for GC diagnosis; however, it is semi-invasive and costly and heavily depends on the skills of the endoscopist, which limit its clinical applicability. Therefore, the search for new sensitive biomarkers for the early detection of GC using noninvasive sampling collection methods has attracted much attention among scientists. Urine is considered an ideal biofluid, as it is readily accessible, less complex, and relatively stable than plasma and serum. Over the years, substantial progress has been made in screening for potential urinary biomarkers for GC. This review explores the possible applications and limitations of urinary biomarkers in GC detection and diagnosis.
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Fugui He,Xianzhi Gao,Xianzheng Zhao,Huilai Wang,Dexiang Yang,Quan Wang 한국지질과학협의회 2017 Geosciences Journal Vol.21 No.4
The Bayindulan Sag situated in Erlian Basin, northeast China, is characterized by pervasive dolomitization in Upper A4 Member to Lower T1 Member of Bayanhua Group. These stratum in the Lower Cretaceous Bayanhua Group were deposited in a lacustrine environments. The main objective of this study is to identify the origin of dolomitization and distribution model of dolomitized rocks. Based on petrographic examination, mud-crystal dolomites (<0.03 mm), silt-crystal dolomites (0.03–0.1 mm) and fine-crystal dolomites (0.1– 0.25 mm) have been observed, and the former two types were predominant. Meanwhile, only one type of dolomite have been defined: replacive dolomite. A variety of dolomite textures have also been observed, the major ones of them are scattered, blocky, joined and annular textures. These dolomites have strongly depleted oxygen isotopic values from –17.48‰ to –6.96‰ with the average of –10.48‰ (PDB), carbon isotopic values from 0.24‰ to 8.37‰ with the average of 5.39‰ (PDB). The obvious depletion of oxygen isotopic was presented as a result of the increase in temperature with progressive burial, and the high carbon isotopic content of dolomites maybe result from the involvement of CO2 in the dolomitization process. These CO2 were generated by bio-methanation which commonly took place in moderately deep burial environments. The Sr values from 62.4 ppm to 262 ppm as well as the Sr/Ba ratios from 0.24 to 0.76 in Tengyi Formation mudstones indicate the freshwater lacustrine sedimentary environments. Taking the petrographic and geochemical data into consideration, the conclusion that the dolomites have formed in a freshwater environments during deep burial depths at temperatures of at least 60 °C can be drawn. Petrographic observations and mineralogy analyses indicate that dolomitization is closely associated with tuffaceous materials, the Mg needed for the dolomitization is provided by dissolution of tuffaceous materials and dolomitization is most probably driven by tuffaceous materials alteration at elevated temperatures.
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Yonghua Wu,Fugui Yang,Hao Zhang,Fengpo Yan,Ruijuan Zuo 한양대학교 세라믹연구소 2021 Journal of Ceramic Processing Research Vol.22 No.4
By the solid-state reaction method, the NaY(WO4)2 : Mn2+, Dy3+, Eu3+ phosphors are synthesized successfully. The sample’sphase-structure and morphology have been characterized by XRD and EDS. The concentrations of Mn2+, Dy3+, Eu3+, Y3+ andW6+ are measured by ICP, The result implies that the doped process of Mn2+, Dy3+ and Eu3+ is very easy in host NaY(WO4)2. The absorption and excited spectra are presented, The absorption spectrum of Mn2+ is always broad, but the Dy3+, Eu3+hasrelatively sharp absorption peaks.Using the commercial LED of 365 nm wavelength as the excitation light, the emission spectrawith different doped concentrations ratios of Mn2+ are obtained. The Mn2 + doping reduces the emission intensity of Dy3+,alsoit has meaningful influence on the tunable green-yellow-red LED.The high doped concentration of Mn2+ can guarantee theemission intensity of 546 nm enough.
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Jing Jing,Sihuan Zhang,Jinbo Wei,Yuhang Yang,Qi Zheng,Cuiyun Zhu,Shuang Li,Hongguo Cao,Fugui Fang,Yong Liu,Ying-hui Ling Asian Australasian Association of Animal Productio 2023 Animal Bioscience Vol.36 No.12
Objective: The aim of this study was to reveal the role and regulatory mechanism of miR-188-5p in the proliferation and differentiation of goat muscle satellite cells. Methods: Goat skeletal muscle satellite cells isolated in the pre-laboratory were used as the test material. First, the expression of miR-188-5p in goat muscle tissues at different developmental stages was detected by quantitative reverse transcription polymerase chain reaction (qRT-PCR). In addition, miR-188-5p was transfected into goat skeletal muscle satellite cells by constructing mimics and inhibitors of miR-188-5p, respectively. The changes of differentiation marker gene expression were detected by qPCR method. Results: It was highly expressed in adult goat latissimus dorsi and leg muscles, goat fetal skeletal muscle, and at the differentiation stage of muscle satellite cells. Overexpression and interference of miR-188-5p showed that miR-188-5p inhibited the proliferation and promoted the differentiation of goat muscle satellite cells. Target gene prediction and dual luciferase assays showed that miR-188-5p could target the 3'untranslated region of the calcium/calmodulin dependent protein kinase II beta (CAMK2B) gene and inhibit luciferase activity. Further functional studies revealed that CAMK2B promoted the proliferation and inhibited the differentiation of goat muscle satellite cells, whereas si-CAMK2B restored the function of miR-188-5p inhibitor. Conclusion: These results suggest that miR-188-5p inhibits the proliferation and promotes the differentiation of goat muscle satellite cells by targeting CAMK2B. This study will provide a theoretical reference for future studies on the molecular mechanisms of skeletal muscle development in goats.
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