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RISS 인기검색어
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- 저자 : Farhan Zafar (검색결과 3 건)
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Wakes of two inline cylinders at a low Reynolds number
Farhan Zafar,Md. Mahbub Alam,Zaka Muhammad,Md. Islam 한국풍공학회 2019 Wind and Structures, An International Journal (WAS Vol.29 No.1
The effect of vortex impingement on the fluid dynamics around a cylinder submerged in the wake of another of different diameters is numerically investigated at a Reynolds number Re = 200. While the diameter (D) of the downstream cylinder is fixed, impinging vortices are produced from the upstream cylinder diameter (d) varied as d/D = 0.24, 0.4, 0.6, 0.8 and 1.0, with a spacing ratio L = 5.5d, where L is the distance between the center of the upstream cylinder to the front stagnation point of the downstream cylinder. Two-dimensional simulations are carried out using the finite volume method. Fluid forces acting on the two cylinders are correlated with impinging vortices, vortex shedding, and wake structure. Different facets of wake formation, wake structure, and flow separation and their connections to fluid forces are discussed.
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Clofarabine in the Treatment of Elderly Patients with Acute Myeloid Leukemia
Aleem, Aamer,Anjum, Farhan,Algahtani, Farjah,Iqbal, Zafar,Alsaleh, Khalid,AlMomen, Abdulkareem Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2
Background: Elderly patients with acute myeloid leukemia (AML) have a poor outcome because of co-morbidities, poor tolerance to intensive chemotherapy and inherently more resistant disease. Clofarabine is a second generation nucleoside analogue which has shown promising activity in elderly patients with AML. This study was conducted to review the outcome of treatment with clofarabine in a group of such patients. Methods: The records of 5 elderly patients who were diagnosed to have AML and treated with clofarabine over a 12 month period were reviewed retrospectively. Results: There were 2 female and 3 male patients with a median age of 68 years (range 65-82). At the time of treatment, 2 patients had newly diagnosed AML not considered suitable for intensive therapy, while 3 patients had partial or no response to conventional chemotherapy. The overall response rate was 100%, all patients achieving a complete remission. Induction and consolidation were well tolerated. All patients developed neutropenia with a median duration of 20 days (range 17-42). One patient developed hand and foot syndrome and a generalized rash but recovered. There was no mortality and all patients remained in remission after a median follow-up of 5.2 months (Range 3-10). Conclusion: Clofarabine (alone or in combination) is active in elderly AML patients with an acceptable safety profile and should be considered a potential option in this group.
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Gillani, Munazza,Akhtar, Farhan,Ali, Zafar,Naz, Irum,Atique, Muhammad,Khadim, Muhammad Tahir Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8
Objective: The objective of this study was to establish the diagnostic accuracy, specificity and sensitivity of fine needle aspiration cytology(FNAC) for intra-oral tumors, comparing with histopathology as the gold standard. Materials and methods: Forty cases of FNA cytology from intraoral tumors was performed in AFID along with the demographic data and clinical information and then diagnosed at AFIP, Rawalpindi. Then the cytology results obtained per FNAC were compared with the histopathological biopsy results of the same lesions. The following variables were recorded for each patient: Age, gender, site of biopsy, diagnosis. The data were entered and analyzed using Open-epi version 2.0. Diagnostic accuracy, sensitivity, specificity, positive predictive value and negative predictive value were calculated. Cohen Kappa was further applied to compare the agreement between the biopsy and FNAC diagnoses. A p-value of < 0.05 was considered as statistically significant. Results: Among the total patients included in the study there were 24 males and 16 females, with a ratio of 1.5:1. Age of the patients ranged from 24 to 80 years with a mean of 52 years. A total of six sites were aspirated from the oral cavity with maximum (11) aspirates taken from alveolar ridge. The results of FNAC revealed that there were 32 malignant and 8 benign aspirates. Confirmation through histopathological analysis came for 31/32 malignant cases while one was falsely given positive for malignancy on FNAC. Among a total of 40 cases, 31(77%) cases diagnosed were found to be malignant and remaining 9(23%) were benign. The FNAC results revealed 32 malignant and 8 benign lesions. Histopathology of the subsequent surgically excised specimen showed malignant lesions in 31(77%) and benign in 9(23%) patients. As a whole, it was found that the absolute sensitivity for introral FNAC was 100% and specificity 89% with positive predictive value of 97% and negative predictive value of 100%. Conclusion: Cytological diagnosis was almost corroborative with final histopathological diagnosis in all cases, with very few exceptions, exhibiting high diagnostic accuracy.
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