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        Assessment of Anti-Inflammatory and Antinociceptive Activities of Olea europaea L.

        İpek Peşin Süntar,Esra Ku¨peli Akkol,Turhan Baykal 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.2

        Leaves and fruits of Olea europaea L. (Family Oleaceae) are used for the treatment of various kinds of diseases, i.e., rheumatism and hemorrhoids, and as a vasodilator in vascular disorders for ages in folk medicine. In order to evaluate this information, anti-inflammatory and antinociceptive activities of the ethanolic and n-hexane extracts prepared from the fruits of O. europaea were investigated. For the anti-inflammatory activity, the carrageenan-induced hind paw edema and acetic acid-induced increased capillary permeability models were used, whereas for the antinociceptive activity, the p-benzoquinone-induced writhing and hot plate tests in mice were used. The results revealed that the ethanolic extract did not show a significant anti-inflammatory or analgesic activity, whereas the n-hexane extract displayed 12.7–27.8% inhibition on the carrageenan-induced hind paw edema model at the 400mg/kg dose, without inducing any apparent acute toxicity as well as gastric damage. Further studies are warranted to define and isolate the active anti-inflammatory and antinociceptive components from this plant, which may yield safe and effective agents to be used in the treatment of inflammatory disorders.

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        Topical Wound-Healing Effects and Phytochemical Composition of Heartwood Essential Oils of Juniperus virginiana L., Juniperus occidentalis Hook., and Juniperus ashei J. Buchholz

        Ibrahim Tumen,Ipek Su¨ntar,Fred J. Eller,Hikmet Keles,Esra Ku¨peli Akkol 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.1

        Ethnobotanical surveys indicated that in the traditional medicines worldwide, several Juniperus species are utilized as antihelmintic, diuretic, stimulant, antiseptic, carminative, stomachic, antirheumatic, antifungal, and for wound healing. In the present study, essential oils obtained from heartwood samples of Juniperus virginiana L., Juniperus occidentalis Hook. and Juniperus ashei J. Buchholz were evaluated for wound healing and anti-inflammatory activities by using in vivo experimental methods. The essential oils were obtained by the supercritical carbon dioxide extraction method. Linear incision and circular excision wound models were performed for the wound-healing activity assessment. The tissues were also evaluated for the hydroxyproline content as well as histopathologically. To evaluate the anti-inflammatory activity of the essential oils, the test used was an acetic acid-induced increase in capillary permeability. The essential oil of J. occidentalis showed the highest activity on the in vivo biological activity models. Additionaly, the oil of J. virginiana was found highly effective in the anti-inflammatory activity method. The experimental data demonstrated that essential oil of J. occidentalis displayed significant wound-healing and anti-inflammatory activities

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