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Synthesis and Quartemization of 6-(Substitutedamino)-Purines with Antitumor Activity Screening
El-Bayouki, Khairy-A.M.,Basyouni, Wahid-M.,El-Din, S.M.,Habeeb, A.G. The Pharmaceutical Society of Korea 1994 Archives of Pharmacal Research Vol.17 No.2
Reaction of c-chloro-9-benzyl-8-(methylthio)purine 3 with primary amines afforoded, the comesponding 6-(substitutedamino)purines 4a-g. The latter products when methylated with methyl iodide yielded smoothly $N^3$-methyl purinium iodide salts 5a-f rather than the probable $N^1\;and\;N^7$-derivatives. 9-Benzyl-3-methyl-6-(methylmino)-8-(methylthio)purine 8 was obtained upon treating the purinium iodide 5a with alkali. Most of the synthesized compounds were screened for their antitumor activity.
Synthesis and Structure of Purine Derivatives as Antitumor Effects
Moharram, H.H.,El-Bayouki, Khairy A.M.,Haggag, B.,Basyouni, W.M.,Osman, A.M. The Pharmaceutical Society of Korea 1989 Archives of Pharmacal Research Vol.12 No.2
The nucleophilic substitution reaction of 6-chloro purines (I) with malononitrile and ethyl cyanoacetate is carried out in DMSO and in the presence of an alkali. The possible tautomeric-ylidene form for the products is considered and discussed in view of IR, UV, NMR and mass spectral determinations. The derivatives were tested for their antitumor activities.