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      • Reinterpreting India's Rise through the Middle Power Prism

        Charalampos Efstathopoulos 서울대학교행정대학원 2011 Asian Journal of Political Science Vol.19 No.1

        India’s spectacular rise in recent years has been the source of hyperbolic theorising andspeculation on its major power status. Middle power theory offers a set of dynamicanalytical parameters which allow for re-evaluating India’s global influence andidentifying both strengths and weaknesses of its power projection and resources. Placingemphasis on themes of Third World leadership, good international citizenship, multilateralactivism, bridge-building diplomacy, and coalition-building with like-mindedstates, the middle power concept can encapsulate key aspects of India’s contemporaryagency and account for structural dynamics which constitute a reformist world-viewthrough the reconfiguration of the Indian state within the existing world order. Overall,middlepowermanship delineates fundamental continuities in India’s foreign policytradition, epitomises India’s existing position in the neoliberal world order, whileproviding a good indication of the directions India will take on the global stage in theshort and medium-term.

      • Suggestion for a New Grading Scale for Radiation Induced Pneumonitis Based on Radiological Findings of Computerized Tomography: Correlation with Clinical and Radiotherapeutic Parameters in Lung Cancer Patients

        Kouloulias, Vassilios,Zygogianni, Anna,Efstathopoulos, Efstathios,Victoria, Oikonomopoulou,Christos, Antypas,Pantelis, Karaiskos,Koutoulidis, Vassilios,Kouvaris, John,Sandilos, Panagiotis,Varela, Mari Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

        Background: The objective of this research is the computed axial tomography (CT) imaging grading of radiation induced pneumonitis (RP) and its correlation with clinical and radiotherapeutic parameters. Materials and Methods: The chest CT films of 20 patients with non-small cell lung cancer who have undergone threedimensional conformal radiation therapy were reviewed. The proposed CT grading of RP is supported on solely radiological diagnosis criteria and distinguishes five grades. The manifestation of RP was also correlated with any positive pre-existing chronic obstructive pulmonary disease (COPD) history, smoking history, the FEV1 value, and the dosimetric variable V20. Results: The CT grading of RP was as follows: 3 patients (15%) presented with ground glass opacity (grade 1), 9 patients (45%) were classified as grade 2, 7 patients (35%) presented with focal consolidation, with or without elements of fibrosis (grade 3), and only one patient (5%) presented with opacity with accompanying atelectasis and loss of pulmonary volume (grade 4). Both univariate and multivariate analysis revealed as prognostic factors for the radiological grading of RP the reduction of FEV1 and the V20 (P=0.026 and P=0.003, respectively). There was also a significant (P<0.001) correlation of radiological grading of RP with FEV1 and V20 (spearman rho 0.92 and 0.93, respectively). Conclusions: The high correlation of the proposed radiological grading with the FEV1 and the V20 is giving a satisfactory clinical validity. Although the proposed grading scale seems relevant to clinical practice, further studies are needed for the confirmation of its validity and reliability.

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        A Cortical Substrate for Square-Wave Jerks in Progressive Supranuclear Palsy

        Evangelos Anagnostou,Efstratios Karavasilis,Irini Potiri,Vasileios Constantinides,Efstathios Efstathopoulos,Elisavet Kapaki,Constantinos Potagas 대한신경과학회 2020 Journal of Clinical Neurology Vol.16 No.1

        Background and Purpose Square-wave jerks (SWJs) are the most common saccadic intrusion in progressive supranuclear palsy (PSP), but their genesis is uncertain. We aimed to determine the characteristics of SWJs in PSP (the Richardson subtype) and Parkinson’s disease (PD) and to map the brain structures responsible for abnormal SWJ parameters in PSP. Methods Eye movements in 12 patients with PSP, 12 patients with PD, and 12 age-matched healthy controls were recorded using an infrared corneal reflection device. The rate, mean amplitude, and velocity of SWJs were analyzed offline. Voxel-based morphometry using a 3-Tesla MRI scanner was performed to relate changes in brain volume to SWJ parameters. Results The SWJ rate was more than threefold higher in PSP patients than in both PD patients and controls (mean rates: 33.5, 10.3, and 4.3 SWJs per minute, respectively). The volumes of neither the midbrain nor other infratentorial brain regions were correlated with the SWJ rate. Instead, highly significant associations were found for atrophy in the superior, middle, and inferior temporal gyri in the PSP group. Conclusions SWJs in PSP are not mediated by midbrain atrophy. Instead, supratentorial cortical structures located mainly in the temporal lobe appear to be deeply involved in the generation of abnormally high SWJ rates in these patients. Known anatomical connections of the temporal lobe to the superior colliculus and the cerebellum might play a role in SWJ genesis.

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