학교유형에 따른 지적장애 학생들의 취업 및 자립성, 삶의 만족도 차이 연구

김도향(Dohyang Kim),강다영(Dayoung Kang),신민근(Mingeun Shin),한지윤(Jiyun Han),황진섭(Jinseub Hwang) 한국자료분석학회 2020 Journal of the Korean Data Analysis Society Vol.22 No.2

본 연구의 목적은 학교유형(일반학교, 일반학교 내 특수학급, 특수학교)에 따른 지적장애 학생들의 취업 및 자립성, 삶의 만족도에 대한 차이를 확인하는 것이며, 이를 통해 지적장애 자녀의 진학문제에 관한 기초연구 자료로 활용되길 기대한다. 본 연구에서는 “2017년 장애인실태조사”자료를 활용하였으며, 전체 대상자 6,549명 중 선천적으로 지적장애를 가진 고등학교 졸업자 52명을 연구대상자로 선정하였다. 성별 및 연령, 지역, 장애등급 등의 교란요인을 기반으로 다범주 로지스틱 회귀모형(multinomial logistic regression model)을 이용하여 학교유형에 대한 성향점수(propensity score)를 추정하였다. 추정된 성향점수를 기반으로 역확률 가중치 방법(inverse probability treatment weighting, IPTW)을 사용하여 학교유형에 따른 지적장애 학생들의 취업 및 자립성, 삶의 만족도에 대한 차이를 비교를 위한 로지스틱 회귀분석(logistic regression)을 진행하였다. 연구결과를 살펴보면, 일반학교보다 일반학교 내 특수학급 또는 특수학교의 취업, 자립성, 삶의 만족도 모두 통계학적으로 높게 나타났다. The purpose of this study is to identify differences in employment, self-reliance, and life satisfaction of intellectually disabled students according to school types (general school, special classes in general school, and special school), and to be used as basic research data on the problem of children with intellectual disabilities. In this study, 52 high school graduates with congenital intellectual disabilities were selected as the subjects of the study out of 6,549 eligible for the “2017 survey on the status of disabilities”. Based on confounding factors such as gender, age, region, and disability grade, use a multinomial logistic regression model to estimate propensity scores for school types. Based on the estimated propensity score, a logistic regression was performed to compare differences in employment, self-reliance and life satisfaction for students with intellectual disabilities according to school types using inverse probability treatment weighting (IPTW). The study result, employment, independence, and life satisfaction of special classes or special school in general schools were all statistically higher than in general school.

공변량의 측정오차를 고려한 소지역 비율의 계층적 베이지안 추정

김도향(Dohyang Kim),황진섭(Jinseub Hwang) 한국자료분석학회 2021 Journal of the Korean Data Analysis Society Vol.23 No.2

본 연구에서는 기존에 개발된 로지스틱 회귀 모형(logistic regression model)을 기반으로 결과변수가 이항분포의 형태를 갖는 베이지안 소지역 비율 추정 모형을 바탕으로 공변량의 측정오차를 반영할 수 있는 확장모형을 제시하였다. 측정오차모형은 측정오차를 가지는 공변량의 참값에 대한 확률성 가정 여부에 따라 기능적 측정오차와 구조적 측정오차로 구분할 수 있으며 본 연구에서는 확률성을 가정하는 구조적 측정오차모형(structural measurement error model)을 고려하였다. 모형추정과 모형적합을 위해 마코브 체인 몬테칼로(Markov chain Monte Carlo) 방법 중 깁스 표집(Gibbs sampling)과 메트로폴리스-해스팅스(Metropolis–Hastings) 알고리즘을 기반으로 하는 계층적 베이지안 접근법을 활용하였다. 모의실험을 통해 개발된 확장모형의 우수성을 확인하였으며 특히 측정오차의 분산 값이 커질수록 더 우수한 성능을 나타내는 것을 확인할 수 있었다. 또한 국가표본자료인 2018년 국민건강영양조사 자료의 중고등학생을 대상으로 수면시간을 측정오차를 가지는 공변량으로 활용하여 시도별 우울감을 느끼는 학생의 비율을 추정하는 실증자료분석을 수행하였다. In this study, we present an expansion model that can reflect the measurement error of covariates based on the previously developed Bayesian small region ratio estimation model based on the logistic regression model in which outcome variable has a binary data form. The measurement error model can be divided into functional and structural measurement error models based on probability assumptions about the true values of covariates with measurement error and the structural measurement error model is considered in this study. A hierarchical Bayesian model was used by sampling using Gibbs sampling and Metropolis– Hastings algorithms among the Markov chain Monte Carlo methods for model estimation and model fitting. We confirm the superiority of the proposal model through simulation, especially the larger the variance value of the measurement error, the performance improved. In addition, an application analysis is conducted to estimate the proportion of depressed students by using sleep time as a covariate with measurement errors for middle and high school students from the 2018 National Health Nutrition survey data which is a national sample data.

Design of Mg-Cu alloys for fast hydrogen production, and its application to PEM fuel cell

Oh, SeKwon,Kim, HyoWon,Kim, MinJoong,Eom, KwangSup,Kyung, JoonSeok,Kim, DoHyang,Cho, EunAe,Kwon, HyukSang Elsevier 2018 Journal of Alloys and Compounds Vol.741 No.-

<P><B>Abstract</B></P> <P>Mg-Cu alloys are designed for fast hydrogen generation by precipitating an electrochemically noble phase (Mg<SUB>2</SUB>Cu) at the grain boundaries. The noble precipitates accelerate the hydrolysis kinetics of the alloy by synergetic action of galvanic and intergranular corrosion. The Mg-3Cu alloy exhibits a hydrogen generation rate of 5.23 ml min<SUP>−1</SUP> g<SUP>−1</SUP>, which is 307 times faster than that of pure Mg (0.017 ml min<SUP>−1</SUP> g<SUP>−1</SUP>). Furthermore, the effects of annealing of the alloy on the hydrogen generation rate and the feasibility of the production of power via hydrolysis of Mg-3Cu alloy are also confirmed. The annealing of the alloy reduces the hydrogen generation rate through the decrease of precipitates, and 10 g of Mg-3Cu alloy can produce power of 7.25 W for 37 min by operation of a single cell PEMFC.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Mg-Cu (1∼3 wt %) alloys were specially designed for fast H<SUB>2</SUB> generation. </LI> <LI> Electrochemically noble phase (Mg<SUB>2</SUB>Cu) was precipitated along the grain boundary. </LI> <LI> H<SUB>2</SUB> generation rate of Mg-3Cu alloy was 307 times faster than that of pure Mg in seawater. </LI> <LI> Enhanced performance is originated from the galvanic, intergranular corrosion. </LI> <LI> Just 10g of Mg-3Cu alloy can produce 7.25 W for 37 min stably via PEMFC operation. </LI> </UL> </P>

Nanoporous structure synthesized by selective phase dissolution of AlCoCrFeNi high entropy alloy and its electrochemical properties as supercapacitor electrode

Kong, Kyeongho,Hyun, Jaeik,Kim, Yongjoo,Kim, Wontae,Kim, Dohyang Elsevier 2019 Journal of Power Sources Vol.437 No.-

<P><B>Abstract</B></P> <P>Fabrication of nanoporous metal core/oxide shell structure using equiatomic AlCoCrFeNi high entropy alloy (HEA) and its electrochemical property as supercapacitor electrode have been investigated in the present study. As-cast AlCoCrFeNi HEA consists of interconnected Al–Ni rich and Cr–Fe rich phases by spinodal phase separation. Nanoporous structure can be obtained by selectively dissolving the Al–Ni rich phase and retaining the remaining Cr–Fe rich phase by passivation in sulfuric acid solution at 313 K. In particular, the scale of nanoporous structure in the present study is predictable since it only depends on the scale of original spinodal-decomposed microstructure in as-cast state. When used as a binder free electrode for supercapacitor, Cr–Fe rich nanoporous structure exhibits high volumetric capacitance of 700 F cm<SUP>−3</SUP> and excellent cycling stability of over 3000 cycle. As the microstructural scale in as-cast state becomes finer, the nanoporous structure exhibits better capacitance properties. The present result shows that Cr–Fe rich nanoporous metal core/oxide shell has a good potential for application as supercapacitor electrode.</P> <P><B>Highlights</B></P> <P> <UL> <LI> AlCoCrFeNi HEA consists of interconnected Al–Ni rich and Cr–Fe rich phase. </LI> <LI> Nanoporous structure is fabricated by selective dissolution of AlCoCrFeNi HEA. </LI> <LI> Nanoporous HEAs exhibits good electrochemical property for supercapacitor. </LI> </UL> </P>

Expression of Active Human Interferon Alpha 2b gene nder the Control of Ovalbumin Promoter in Transgenic Chickens

Bon Chul Koo,Mo Sun Kwon,Dohyang Kim,Sanga Kim,Museog Choe,Yuhwa Nam,Teoan Kim 한국동물생명공학회(구 한국동물번식학회) 2016 발생공학 국제심포지엄 및 학술대회 Vol.2016 No.10

Production of Germline Transgenic Chickens Expressing High levels of Recombinant hEPO using a MoMLV-based Retrovirus Vector

Bon Chul Koo,Mo Sun Kwon,Dohyang Kim,Sanga Kim,Museog Choe,Yuhwa Nam,Teoan Kim 한국동물생명공학회(구 한국동물번식학회) 2016 발생공학 국제심포지엄 및 학술대회 Vol.2016 No.10

Production of Germline Transgenic Chickens Expressing High levels of Recombinant hEPO using a MoMLV-based Retrovirus Vector

Bon Chul Koo,Mo Sun Kwon,Dohyang Kim,Sanga Kim,Museog Choe,Yuhwa Nam,Teoan Kim 한국수정란이식학회 2016 한국수정란이식학회 학술대회 Vol.2016 No.10

In the present study, using a MoMLV-based retrovirus vector, we successfully generated a new transgenic chicken line expressing high levels of hEPO. A replication-defective Moloney murine leukemia virus (MoMLV)-based vectors packaged with vesicular stomatitis virus G glycoprotein (VSV-G) was injected beneath the blastoderm of non-incubated chicken embryos (stage X). One rooster was mated to wild-type hens to produce 748 G1 progeny. PCR analysis of blood samples from these progeny revealed that there were seven G1 transgenic offspring, corresponding to a 0.9% germline transmission rate. Subsequently, Southern blot analysis of the genomic DNA from three G1 transgenic chickens was carried out to verify the stable genomic integration and copy number of the transgene in the genome. Quantitative analyses of the blood samples taken from G1 transgenic chickens resulted in 4,150 ~ 10,823 IU/㎖ (34.6 ~ 90.2 ㎍/㎖) of hEPO in the blood. The biological activity of the recombinant hEPO in transgenic chicken serum was comparable to its commercially available counterpart. Red blood cell numbers were more than three-fold higher in the transgenic chickens compared to the non-transgenic chickens. Successful germline transmission of the transgene was also confirmed in G2 transgenic chicks produced from crossing G1 transgenic roosters with non-transgenic hens. We confirmed that 13 transgenic chicks of 45 G2 progeny, corresponding to a 28.9% germline transmission rate. These results will help establish a useful transgenic chicken model system for studies of embryonic development and for efficient production of transgenic chickens as bioreactors. This work was supported by the Bio-industry Technology Development Program, Ministry of Agriculture, Food and Rural Affairs, Republic of Korea, and by a grant from the Next-Generation BioGreen 21 Program (No. PJ011178), Rural Development Administration, Republic of Korea.

Expression of Active Human Interferon Alpha 2b gene nder the Control of Ovalbumin Promoter in Transgenic Chickens

Bon Chul Koo,Mo Sun Kwon,Dohyang Kim,Sanga Kim,Museog Choe,Yuhwa Nam,Teoan Kim 한국수정란이식학회 2016 한국수정란이식학회 학술대회 Vol.2016 No.10

Human interferon alpha 2b (hIFNα-2b) is an important immune regulator widely used in clinic, for the treatment of chronic hepatitis, hairy cell leukemia, chronic myelogenous leukemia and multiple myeloma, etc. The clinically used hIFNα-2b is generally produced by E. Coli, which lacks the post-translational O-glycosylation of naturally synthesized protein, and has a short serum half-life. In this study, we report the successful generation of transgenic chickens that produce hIFNα-2b in the egg white using a feline immunodeficiency virus (FIV)-based lentiviral vector. In preliminary in vitro study, the hIFNα-2b gene under the control of CMV promoter expressed as much as 2,650 ng/㎖ in CEF-LNC-hIFNα-2bW cell. A FIV vector packaged with vesicular stomatitis virus G glycoprotein (VSV-G) was injected underneath the blastoderm of freshly laid chicken eggs (stage X) to produce a hIFNα -2b transgenic chicken. Out of 187 injected eggs, 55 chicks were hatched after 21 days of incubation, and 27 of the G0 hatched chicks expressed the vector-encoded hIFNα-2b gene. The expression of recombinant hIFNα-2b in transgenic chickens constitutes an important step towards low-cost and full biological activity production of this protein drug in bioreactor. This work was supported by the Bio-industry Technology Development Program, Ministry of Agriculture, Food and Rural Affairs, Republic of Korea, and by a grant from the Next-Generation BioGreen 21 Program (No. PJ011178), Rural Development Administration, Republic of Korea.

Tetracycline-dependent expression of the human erythropoietin gene in transgenic chickens

Koo, Bon Chul,Kwon, Mo Sun,Lee, Hyuna,Kim, Minjee,Kim, Dohyang,Roh, Ji Yeol,Park, Yoon-Yub,Cui, Xiang-Shun,Kim, Nam-Hyung,Byun, Sung June,Kim, Teoan Springer-Verlag 2010 Transgenic research Vol.19 No.3

Fabrication of Mg–Ni–Sn alloys for fast hydrogen generation in seawater

Oh, SeKwon,Cho, TaeHee,Kim, MinJoong,Lim, JeongHoon,Eom, KwangSup,Kim, DoHyang,Cho, EunAe,Kwon, HyukSang Pergamon Press 2017 International journal of hydrogen energy Vol.42 No.12

<P><B>Abstract</B></P> <P>Mg-2.7Ni-x wt.% Sn(x = 0–2) alloys were fabricated to promote hydrogen generation kinetics of Mg-2.7Ni alloy. The Sn in Mg-2.7Ni-Sn alloys exists as Mg<SUB>2</SUB>Sn phase at the grain boundary and solid solution at the Mg matrix. The Mg<SUB>2</SUB>Sn at the grain boundary acts as the initiation site for pitting corrosion and the dissolved Sn in the alloy causes pitting corrosion by locally breaking the surface oxide film in the Mg matrix in seawater. The Mg-2.7Ni-1Sn alloy showed an excellent hydrogen generation rate of 28.71 ml min<SUP>−1</SUP> g<SUP>−1</SUP>, which is 1700 times faster than that of pure Mg due to the combined action of galvanic and intergranular corrosion as well as pitting corrosion in seawater. As the solution temperature was increased from 30 to 70 °C, the hydrogen generation rate from the hydrolysis of the Mg-2.7Ni-1Sn alloy was dramatically increased from 34 to 257.3 ml min<SUP>−1</SUP> g<SUP>−1</SUP>. The activation energy for the hydrolysis of Mg was calculated to be 43.13 kJ mol<SUP>−1</SUP>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The Mg–Ni–Sn alloys were specially designed to fast generate H<SUB>2</SUB> in seawater. </LI> <LI> The Mg<SUB>2</SUB>Sn at the grain boundary acts as the initiation site for pitting corrosion. </LI> <LI> The dissolved Sn causes pitting corrosion by locally breaking the surface oxide film. </LI> <LI> H<SUB>2</SUB> generation rate of Mg-2.7Ni-1Sn was 1700 times faster than that of pure Mg in seawater. </LI> <LI> Enhanced performance was attributed to pitting, galvanic and intergranular corrosion. </LI> </UL> </P>