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Carren M. Bosire,Tsegaye Deyou,Jacques M. Kabaru,DennisM. Kimata,Abiy Yenesew 한국응용곤충학회 2014 Journal of Asia-Pacific Entomology Vol.17 No.3
The dichloromethane/methanol (1:1) extract of the stem bark of Millettia usaramensis subspecies usaramensiswas tested for its larvicidal activity against the 4th instar Aedes aegypti larvae and demonstrated activity withLC50 value of 50.8±0.06 μg/mL at 48 h. Compounds isolated from the extractwere also tested for their larvicidalactivities, and the rotenoid usararotenoid-A (LC50 4.3 ± 0.8 μg/mL at 48 h) was identified as the most activeprinciple. This compound appears to be the first rotenoid having a trans-B/C ring junction and methylenedioxygroup at C-2/C-3 with high larvicidal activity. Related rotenoids with the same configuration at the B/C-ringjunction did not show significant activity at 100 μg/mL.